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Table 3 Association of baseline hs-CRP and longitudinal hs-CRP changes with incident MetS among age, sex and BMI subgroups (N = 4,116)

From: Association between baseline and changes in high-sensitive C-reactive protein and metabolic syndrome: a nationwide cohort study and meta-analysis

Subgroups

Quartiles of hs-CRP at baseline

P for interactiona

Groups of absolute changes in hs-CRP during the follow–up

P for interactiona

Quartile 1

Quartile 2

Quartile 3

Quartile 4

Group 1

Group 2

Group 3

Group 4

Age

    

0.41

    

0.66

 45–60 years

          

  Case/total

50/692

83/630

83/597

103/560

 

76/862

52/545

81/543

110/529

 

  OR (95% CI)b

1.00 (Ref.)

1.70 (1.16, 2.53)

1.64 (1.11, 2.44)

2.03 (1.39, 3.00)

 

1.00 (Ref.)

1.62 (1.05, 2.49)

2.65 (1.78, 3.95)

3.63 (2.52, 5.27)

 

 > 60 years

          

  Case/total

30/335

47/389

61/442

78/471

 

64/617

25/328

52/325

75/367

 

  OR (95% CI)b

1.00 (Ref.)

1.26 (0.77, 2.1)

1.29 (0.80, 2.11)

1.57 (0.99, 2.54)

 

1.00 (Ref.)

0.97 (0.56, 1.66)

2.27 (1.43, 3.6)

2.92 (1.93, 4.47)

 

Sex

    

0.66

    

0.68

 Male

          

  Case/total

34/437

54/453

57/509

78/530

 

59/727

26/398

55/366

83/438

 

  OR (95% CI)b

1.00 (Ref.)

1.50 (0.94, 2.44)

1.25 (0.78, 2.03)

1.80 (1.15, 2.86)

 

1.00 (Ref.)

0.94 (0.54, 1.61)

2.52 (1.59, 4.01)

3.64 (2.42, 5.54)

 

 Female

          

  Case/total

46/590

76/566

87/530

103/501

 

81/752

51/475

78/502

102/458

 

  OR (95% CI)b

1.00 (Ref.)

1.55 (1.04, 2.33)

1.70 (1.15, 2.55)

1.90 (1.28, 2.84)

 

1.00 (Ref.)

1.70 (1.10, 2.63)

2.60 (1.75, 3.90)

3.3 (2.28, 4.83)

 

BMI

    

0.69

    

0.40

 BMI < 24.0 kg/m2

          

  Case/total

44/817

56/722

56/705

73/655

 

53/1,035

31/638

62/608

83/618

 

  OR (95% CI)b

1.00 (Ref.)

1.47 (0.97, 2.24)

1.38 (0.91, 2.11)

2.05 (1.38, 3.07)

 

1.00 (Ref.)

1.46 (0.88, 2.42)

3.23 (2.09, 5.05)

4.08 (2.73, 6.18)

 

 BMI ≥ 24.0 kg/m2

          

  Case/total

36/210

74/297

88/334

108/376

 

87/444

46/235

71/260

102/278

 

  OR (95% CI)b

1.00 (Ref.)

1.61 (1.02, 2.57)

1.64 (1.05, 2.60)

1.79 (1.16, 2.80)

 

1.00 (Ref.)

1.3 (0.83, 2.02)

2.09 (1.39, 3.15)

2.85 (1.96, 4.17)

 
  1. BMI, body mass index; CI, confidence interval; hs-CRP, high-sensetive C reactive protein; MetS, metabolic syndrome; OR, odds ratio
  2. aP values for interaction were estimated using the likelihood ratio test for the product term of the stratifying variables and hs-CRP groups to the main model
  3. bAll models were adjusted for age (continuous, years), sex (male and female), education level (illiterate, primary school, middle school, and high school or above), and residence (urban and rural), cigarette smoking (never, former, and current), alcohol drinking (never, former, and current), BMI (continuous, kg/m2), hypertension (yes and no), dyslipidemia (yes and no), diabetes (yes and no), heart disease (yes and no) and stroke (yes and no)
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Nutrition & Metabolism

ISSN: 1743-7075

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