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Table 4 Association of baseline hs-CRP and longitudinal hs-CRP changes with components of MetS

From: Association between baseline and changes in high-sensitive C-reactive protein and metabolic syndrome: a nationwide cohort study and meta-analysis

Components

Quartiles of hs-CRP at baseline

Per 1 log mg/L increase

P for trenda

Groups of absolute changes in hs-CRP during the follow–up

P for trenda

Quartile 1

Quartile 2

Quartile 3

Quartile 4

Group 1

Group 2

Group 3

Group 4

Elevated WC

           

 Case/total

127/820

158/817

175/828

195/823

655/3,288

 

190/1,184

122/697

179/692

164/715

 

 OR (95% CI)b

1.00 (Ref.)

1.14 (0.86, 1.50)

1.18 (0.89, 1.56)

1.46 (1.10, 1.93)

1.17 (1.04, 1.30)

0.01

1.00 (Ref.)

1.12 (0.85, 1.47)

1.85 (1.43, 2.39)

1.72 (1.32, 2.24)

 < 0.001

Elevated TG

           

 Case/total

181/1,020

211/1,061

233/1,064

259/1,053

884/4,198

 

209/1,539

137/883

248/876

290/900

 

 OR (95% CI)b

1.00 (Ref.)

1.11 (0.88, 1.39)

1.19 (0.95, 1.49)

1.32 (1.06, 1.66)

1.13 (1.04, 1.24)

0.02

1.00 (Ref.)

1.2 (0.94, 1.52)

2.56 (2.07, 3.17)

3.08 (2.50, 3.80)

 < 0.001

Reduced HDL-C

           

 Case/total

67/1,098

86/1,096

79/1,099

78/1,101

310/4,394

 

67/1,556

53/939

59/935

131/964

 

 OR (95% CI)b

1.00 (Ref.)

1.19 (0.85, 1.67)

1 (0.71, 1.41)

0.91 (0.64, 1.30)

0.96 (0.84, 1.11)

0.27

1.00 (Ref.)

1.39 (0.96, 2.02)

1.56 (1.08, 2.25)

3.50 (2.57, 4.79)

 < 0.001

Elevated BP

           

 Case/total

164/701

194/699

189/700

204/703

751/2,803

 

249/972

164/607

159/601

179/623

 

 OR (95% CI)b

1.00 (Ref.)

1.10 (0.86, 1.42)

0.98 (0.76, 1.27)

1.05 (0.82, 1.36)

1.04 (0.94, 1.15)

0.91

1.00 (Ref.)

1.11 (0.87, 1.40)

1.1 (0.86, 1.40)

1.14 (0.90, 1.45)

0.29

Elevated FBG

           

 Case/total

86/1,003

110/993

138/1,016

158/1,005

493/4,027

 

161/1,414

64/860

109/858

158/985

 

 OR (95% CI)b

1.00 (Ref.)

1.20 (0.89, 1.63)

1.42 (1.06, 1.90)

1.58 (1.18, 2.12)

1.22 (1.09, 1.37)

0.01

1.00 (Ref.)

0.65 (0.48, 0.88)

1.16 (0.89, 1.51)

1.60 (1.25, 2.04)

 < 0.001

  1. BMI, body mass index; BP, blood pressure; FBG, fasting blood glucose; HDL-C, high-density lipoprotein cholesterol; hs-CRP, high-sensitive C-reactive protein; MetS, metabolic syndrome; TG, triglycerides; WC, waist circumference
  2. aP values for trend were estimated by modelling the serum high-sensitive C-reactive protein using the median for each category
  3. bAll models were adjusted for age (continuous, years), sex (male and female), education level (illiterate, primary school, middle school, and high school or above), and residence (urban and rural), cigarette smoking (never, former, and current), alcohol drinking (never, former, and current), BMI (continuous, kg/m2), hypertension (yes and no), dyslipidemia (yes and no), diabetes (yes and no), heart disease (yes and no) and stroke (yes and no)