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Fig. 5 | Nutrition & Metabolism

Fig. 5

From: The role and possible mechanism of the long noncoding RNA LINC01260 in nonalcoholic fatty liver disease

Fig. 5

CeRNA network analysis of LINC01260. A Bioinformatic analysis of mRNAs co-expressed with LINC01260. RXRB, RNPEPL1, CD82, MADD and KLC2 were enriched. B Validation of co-expressed mRNAs by qPCR, and all were consistent with sequencing (*P < 0.05, **P < 0.01). C Overexpression of LINC01260 (LINC01260 +) increased the expression RXRB significantly (*P < 0.05) compared with pcDNA3.1 groups. D Western blots proved the upregulation trends of RXRB protein in LINC01260 + cells. E RXRB siRNAs decreased RXRB gene expression significantly (*P < 0.05). F RXRB siRNAs decreased RXRB protein expression significantly (*P < 0.05). G RXRB siRNA attenuated the decrease of lipids induced by LINC01260 overexpression

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