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Table 1 Baseline characteristics of cases and control

From: Association of serum choline levels and all-cause mortality risk in adults with hypertension: a nested case–control study

Variables All patients (n = 558) Controls (n = 279) Cases (n = 279) P
Age, years 64.13 (57.33–70.59) 64.13 (57.33–70.57) 64.12 (57.34–70.72) 0.976
Male, n (%) 318 (57.0) 159 (57.0) 159 (57.0) 1.000
BMI, kg/m2 24.54 (22.24–27.18) 25.04 (22.64–27.34) 24.34 (21.84–26.73) 0.033
Current smoking, n (%) 190 (34.1) 93 (33.3) 97 (34.8) 0.925
Current drinking, n (%) 181 (32.4) 96 (34.4) 85 (30.5) 0.551
Baseline SBP, mmHg 168.00 (156.00–181.83) 165.33 (154.67–180.67) 170.67 (157.33–183.00) 0.081
Baseline DBP, mmHg 94.67 (88.00–101.33) 93.33 (88.0–100.0) 96.67 (88.00–102.00) 0.152
Treatment group     
 Enalapril 298 (53.4) 149 (53.4) 149 (53.4) 1.000
 Enalapril-folic acid 260 (46.6) 130 (46.6) 130 (46.6)  
MTHFR C677T     
 CC 137 (24.6) 70 (25.1) 67 (24.0) 0.626
 CT 277 (49.6) 142 (50.9) 135 (48.4)  
 TT 144 (25.8) 67 (24.0) 77 (27.6)  
Triglyceride, mmol/L 1.43 (1.06–1.99) 1.47 (1.05–2.09) 1.38 (1.07–1.93) 0.295
Total cholesterol, mmol/L 5.54 (4.78–6.22) 5.54 (4.94–6.21) 5.54 (4.64–6.22) 0.407
Uric acid, mg/dL 304.00 (256.00–356.00) 302.00 (254.50–354.00) 305.00 (257.00–361.00) 0.437
HDL cholesterol, mmol/L 1.29 (1.07–1.52) 1.29 (1.09–1.52) 1.29 (1.05–1.58) 0.967
Glucose, mmol/L 5.63 (5.17–6.34) 5.58 (5.17–6.32) 5.63 (5.19–6.40) 0.411
Creatinine, mmol/L 68.70 (58.30–79.28) 68.70 (57.35–80.05) 68.70 (58.55–76.95) 0.703
Serum Folic acid, ng/mL 6.50 (4.87–9.09) 6.57 (4.66–9.20) 6.50 (4.94–8.82) 0.915
Homocysteine, μmol/L 13.72 (11.02–18.82) 13.70 (10.78–18.27) 13.72 (11.17–19.25) 0.289
Choline, μg/ml 8.99 (4.00–13.33) 7.80 (3.37–12.72) 9.51 (4.45–13.89) 0.009
  1. Continuous variables are presented as median (quantile1–quantile3), categorical variables are presented as n (%).
  2. Differences in baseline characteristics between cases and controls were compared using χ2 tests for categorical variables and Wilcoxon signed rank tests for continuous variables.
  3. SD, standard deviation; SBP, systolic blood pressure; DBP, diastolic blood pressure; MTHFR, 5,10-methylenetetrahydrofolate reductase; CC, CT and TT are different genotypes of MTHFR.