Fig. 6

A, B The mRNA expression level of DEGs in RNA-seq analysis. C, D The mRNA expression level of glucogenesis, lipogenesis, lipid synthesis and lipolysis in liver and fat tissue mice (n = 5 per genotype). E, F Western blot and quantification of p-mTOR/t-mTOR, PPAR-γ, FAS, G-6-P and PCK in liver. Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 by unpaired Student t test or Mann–Whitney U test. Pla2g1b phospholipase A2g4a, Fabp4 fatty acid binding protein 4, Lpl lipoprotein lipase, Cel carboxyl ester lipase, Ceslg carboxylesterase 1G, Fasn fatty acid synthase, G-6-p glucose 6 phosphatase, Ucp1 uncoupling protein-1, Pnliprp1 pancreatic lipase related protein 1, Pnlip pancreatic lipase, Clps colipase