Characteristics | Overall | NAFLD (n = 1446) | Non-NAFLD (n = 1368) | P value |
---|---|---|---|---|
Demographics | ||||
Age (years) | 60.84 ± 5.76 | 61.97 ± 5.45 | 60.71 ± 6.06 | 0.221 |
Sex (male) | 868 (30.85) | 468 (32.37) | 400 (29.24) | 0.073 |
Anthropometrics | ||||
BMI (kg/m2) | 23.61 ± 3.16 | 25.01 ± 3.00 | 22.13 ± 2.60 | < 0.001 |
Waist (cm) | 84.91 ± 8.80 | 88.34 ± 8.15 | 81.29 ± 7.98 | < 0.001 |
WHR | 0.92 ± 0.07 | 0.94 ± 0.06 | 0.90 ± 0.07 | < 0.001 |
Trunk fat percentage (%) | 33.62 ± 6.74 | 35.65 ± 5.85 | 31.49 ± 6.95 | < 0.001 |
SBP (mmHg) | 125.21 ± 17.93 | 128.37 ± 17.51 | 121.88 ± 17.76 | < 0.001 |
DBP (mmHg) | 75.57 ± 10.37 | 77.56 ± 10.16 | 73.48 ± 10.18 | < 0.001 |
Blood biochemical indices | ||||
Fasting glucose (mM) | 4.80 [4.39, 5.31] | 4.85 [4.43, 5.41] | 4.72 [4.33, 5.21] | < 0.001 |
Fasting insulin (μU/mL) | 7.77 [5.39, 11.21] | 9.97 [7.00, 13.86] | 6.08 [4.42, 8.27] | < 0.001 |
HOMA-IR | 1.67 [1.11, 2.54] | 2.18 [1.49, 3.18] | 1.30 [0.90, 1.84] | < 0.001 |
AST/ALT | 1.20 [0.96, 1.45] | 1.09 [0.87, 1.33] | 1.30 [1.08, 1.56] | < 0.001 |
TC (mM) | 5.59 ± 1.05 | 5.56 ± 1.03 | 5.63 ± 1.07 | 0.059 |
TG (mM) | 1.26 [0.90, 1.78] | 1.44 [1.04, 2.06] | 1.08 [0.81, 1.50] | < 0.001 |
HDL-C (mM) | 1.43 ± 0.41 | 1.32 ± 0.36 | 1.55 ± 0.43 | < 0.001 |
LDL-C (mM) | 3.60 ± 0.91 | 3.62 ± 0.90 | 3.57 ± 0.91 | 0.140 |
UA (μM) | 350.50 ± 84.32 | 364.68 ± 83.31 | 335.49 ± 82.80 | < 0.001 |
ALP (U/L) | 70.07 [58.87, 83.07] | 71.25 [59.47, 84.08] | 68.85 [58.23, 81.76] |  < 0.001 |
hsCRP (mg/L) | 0.96 [0.57, 1.94] | 1.19 [0.67, 2.44] | 0.77 [0.48, 1.38] | < 0.001 |
Serum methionine metabolites | ||||
SAM (nM) | 88.07 [75.04, 110.04] | 91.06 [76.90, 111.19] | 85.67 [73.62, 108.74] | < 0.001 |
SAH (nM) | 15.70 [11.46, 24.55] | 17.74 [12.09, 26.24] | 14.50 [10.84, 22.64] | < 0.001 |
Hcy (μM) | 13.06 [11.33, 16.39] | 13.61 [11.66, 17.43] | 12.51 [10.97, 15.35] | < 0.001 |
SAM/SAH | 5.68 [4.18, 7.20] | 5.31 [3.99, 7.01] | 6.09 [4.47, 7.42] | < 0.001 |
Lifestyle | ||||
Physical activities (MET/day) | 34.05 ± 5.65 | 33.69 ± 5.55 | 34.43 ± 5.73 | < 0.001 |
Current smoking | 313 (11.12) | 164 (11.34) | 149 (10.89) | 0.704 |
Current drinking | 204 (7.25) | 109 (7.54) | 95 (6.94) | 0.540 |
Methionine intake (mg/day) | 1131.37 ± 283.31 | 1137.89 ± 290.34 | 1124.85 ± 276.24 | 0.223 |
Folate intake (ng/day) | 210.56 ± 83.95 | 212.12 ± 92.80 | 208.91 ± 73.44 | 0.308 |
Vitamin B12 intake (ng/day) | 1.43 ± 1.01 | 1.45 ± 1.15 | 1.41 ± 0.85 | 0.257 |
History of disease | ||||
Hypertension | 825 (29.35) | 518 (35.85) | 307 (22.47) | < 0.001 |
Diabetes | 213 (7.58) | 127 (8.79) | 86 (6.30) | 0.019 |
Dyslipidemia | 1099 (39.05) | 647 (44.74) | 452 (33.04) | < 0.001 |
Heart diseases | 559 (19.91) | 302 (20.91) | 257 (18.84) | 0.330 |