| |
Quartiles of serum methionine metabolites
|
P for trend
|
|---|
|
Quartile 1
|
Quartile 2
|
Quartile 3
|
Quartile 4
|
|---|
|
SAM (nM)
|
< 75.05
|
75.05–88.06
|
88.07–110.03
|
> 110.04
| |
|
NAFLD (%)
|
44.52
|
50.64
|
56.45
|
53.91
|
< 0.001
|
|
Model 1
|
1.00
|
1.34 (1.08, 1.66)
|
1.66 (1.33, 2.06)
|
1.43 (1.15, 1.79)
|
< 0.001
|
|
Model 2
|
1.00
|
1.07 (0.83, 1.38)
|
1.32 (1.03, 1.70)
|
0.99 (0.77, 1.28)
|
0.636
|
|
Model 3
|
1.00
|
1.01 (0.78, 1.31)
|
1.24 (0.96, 1.61)
|
0.97 (0.74, 1.26)
|
0.795
|
|
SAH (nM)
|
< 11.46
|
11.46–15.69
|
15.70–24.52
|
> 24.53
| |
|
NAFLD (%)
|
40.48
|
49.21
|
51.28
|
64.58
|
< 0.001
|
|
Model 1
|
1.00
|
1.38 (1.11, 1.71)
|
1.50 (1.21, 1.87)
|
2.46 (1.97, 3.08)
|
< 0.001
|
|
Model 2
|
1.00
|
1.16 (0.92, 1.51)
|
1.27 (0.99, 1.63)
|
1.74 (1.35, 2.24)
|
< 0.001
|
|
Model 3
|
1.00
|
1.16 (0.90, 1.50)
|
1.27 (0.98, 1.65)
|
1.65 (1.27, 2.14)
|
< 0.001
|
|
Hcy (μM)
|
< 11.33
|
11.33–13.05
|
13.06–16.37
|
> 16.38
| |
|
NAFLD (%)
|
40.83
|
49.79
|
51.07
|
63.87
|
< 0.001
|
|
Model 1
|
1.00
|
1.42 (1.15, 1.76)
|
1.42 (1.14, 1.76)
|
2.41 (1.93, 3.01)
|
< 0.001
|
|
Model 2
|
1.00
|
1.19 (0.93, 1.53)
|
1.07 (0.84, 1.38)
|
1.73 (1.34, 2.23)
|
< 0.001
|
|
Model 3
|
1.00
|
1.23 (0.96, 1.60)
|
1.09 (0.84, 1.41)
|
1.63 (1.26, 2.12)
|
0.001
|
|
SAM/SAH
|
< 4.16
|
4.16–5.74
|
5.75–7.21
|
> 7.22
| |
|
NAFLD (%)
|
60.26
|
53.79
|
46.75
|
44.57
|
< 0.001
|
|
Model 1
|
1.00
|
0.77 (0.62, 0.96)
|
0.60 (0.41, 0.75)
|
0.57 (0.46, 0.71)
|
< 0.001
|
|
Model 2
|
1.00
|
0.81 (0.63, 1.04)
|
0.64 (0.50, 0.82)
|
0.62 (0.48, 0.80)
|
< 0.001
|
|
Model 3
|
1.00
|
0.80 (0.62, 1.03)
|
0.64 (0.49, 0.83)
|
0.63 (0.49, 0.83)
|
< 0.001
|
- Model 1: adjusted for age, sex
- Model 2: adjusted as for model 1 plus BMI, WHR, trunk fat ratio, physical activity (MET/day), current smoking, current drinking, history of hypertension, diabetes, dyslipidemia and heart disease;
- Model 3: adjusted as for model 2 plus HOMA-IR, TC, TG, HDL, LDL, AST/ALT ratio, UA, ALP and hsCRP
