Table 3 Adjusted ORs (95% CI) for NAFLD prevalence by quartiles of serum methionine metabolites

SAM (nM)

< 75.05

75.05–88.06

88.07–110.03

> 110.04

 NAFLD (%)

44.52

50.64

56.45

53.91

< 0.001

  Model 1

1.00

1.34 (1.08, 1.66)

1.66 (1.33, 2.06)

1.43 (1.15, 1.79)

< 0.001

  Model 2

1.00

1.07 (0.83, 1.38)

1.32 (1.03, 1.70)

0.99 (0.77, 1.28)

0.636

  Model 3

1.00

1.01 (0.78, 1.31)

1.24 (0.96, 1.61)

0.97 (0.74, 1.26)

0.795

SAH (nM)

 < 11.46

11.46–15.69

15.70–24.52

> 24.53

 NAFLD (%)

40.48

49.21

51.28

64.58

< 0.001

  Model 1

1.00

1.38 (1.11, 1.71)

1.50 (1.21, 1.87)

2.46 (1.97, 3.08)

< 0.001

  Model 2

1.00

1.16 (0.92, 1.51)

1.27 (0.99, 1.63)

1.74 (1.35, 2.24)

< 0.001

  Model 3

1.00

1.16 (0.90, 1.50)

1.27 (0.98, 1.65)

1.65 (1.27, 2.14)

< 0.001

Hcy (μM)

< 11.33

11.33–13.05

13.06–16.37

> 16.38

 NAFLD (%)

40.83

49.79

51.07

63.87

< 0.001

  Model 1

1.00

1.42 (1.15, 1.76)

1.42 (1.14, 1.76)

2.41 (1.93, 3.01)

< 0.001

  Model 2

1.00

1.19 (0.93, 1.53)

1.07 (0.84, 1.38)

1.73 (1.34, 2.23)

< 0.001

  Model 3

1.00

1.23 (0.96, 1.60)

1.09 (0.84, 1.41)

1.63 (1.26, 2.12)

0.001

SAM/SAH

< 4.16

4.16–5.74

5.75–7.21

> 7.22

 NAFLD (%)

60.26

53.79

46.75

44.57

< 0.001

  Model 1

1.00

0.77 (0.62, 0.96)

0.60 (0.41, 0.75)

0.57 (0.46, 0.71)

< 0.001

  Model 2

1.00

0.81 (0.63, 1.04)

0.64 (0.50, 0.82)

0.62 (0.48, 0.80)

< 0.001

  Model 3

1.00

0.80 (0.62, 1.03)

0.64 (0.49, 0.83)

0.63 (0.49, 0.83)

< 0.001