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Table 3 Adjusted ORs (95% CI) for NAFLD prevalence by quartiles of serum methionine metabolites

From: Association of serum methionine metabolites with non-alcoholic fatty liver disease: a cross-sectional study

  Quartiles of serum methionine metabolites P for trend
Quartile 1 Quartile 2 Quartile 3 Quartile 4
SAM (nM) < 75.05 75.05–88.06 88.07–110.03 > 110.04  
 NAFLD (%) 44.52 50.64 56.45 53.91 < 0.001
  Model 1 1.00 1.34 (1.08, 1.66) 1.66 (1.33, 2.06) 1.43 (1.15, 1.79) < 0.001
  Model 2 1.00 1.07 (0.83, 1.38) 1.32 (1.03, 1.70) 0.99 (0.77, 1.28) 0.636
  Model 3 1.00 1.01 (0.78, 1.31) 1.24 (0.96, 1.61) 0.97 (0.74, 1.26) 0.795
SAH (nM)  < 11.46 11.46–15.69 15.70–24.52 > 24.53  
 NAFLD (%) 40.48 49.21 51.28 64.58 < 0.001
  Model 1 1.00 1.38 (1.11, 1.71) 1.50 (1.21, 1.87) 2.46 (1.97, 3.08) < 0.001
  Model 2 1.00 1.16 (0.92, 1.51) 1.27 (0.99, 1.63) 1.74 (1.35, 2.24) < 0.001
  Model 3 1.00 1.16 (0.90, 1.50) 1.27 (0.98, 1.65) 1.65 (1.27, 2.14) < 0.001
Hcy (μM) < 11.33 11.33–13.05 13.06–16.37 > 16.38  
 NAFLD (%) 40.83 49.79 51.07 63.87 < 0.001
  Model 1 1.00 1.42 (1.15, 1.76) 1.42 (1.14, 1.76) 2.41 (1.93, 3.01) < 0.001
  Model 2 1.00 1.19 (0.93, 1.53) 1.07 (0.84, 1.38) 1.73 (1.34, 2.23) < 0.001
  Model 3 1.00 1.23 (0.96, 1.60) 1.09 (0.84, 1.41) 1.63 (1.26, 2.12) 0.001
SAM/SAH < 4.16 4.16–5.74 5.75–7.21 > 7.22  
 NAFLD (%) 60.26 53.79 46.75 44.57 < 0.001
  Model 1 1.00 0.77 (0.62, 0.96) 0.60 (0.41, 0.75) 0.57 (0.46, 0.71) < 0.001
  Model 2 1.00 0.81 (0.63, 1.04) 0.64 (0.50, 0.82) 0.62 (0.48, 0.80) < 0.001
  Model 3 1.00 0.80 (0.62, 1.03) 0.64 (0.49, 0.83) 0.63 (0.49, 0.83) < 0.001
  1. Model 1: adjusted for age, sex
  2. Model 2: adjusted as for model 1 plus BMI, WHR, trunk fat ratio, physical activity (MET/day), current smoking, current drinking, history of hypertension, diabetes, dyslipidemia and heart disease;
  3. Model 3: adjusted as for model 2 plus HOMA-IR, TC, TG, HDL, LDL, AST/ALT ratio, UA, ALP and hsCRP