Fig. 6

Effect of FGF19 on Abcb1 efflux function. A Efflux transport of Rho 123 through Abcb1. Organoids were treated with FGF19 (50 ng/ml) for 6 days. Verapamil (100 uM) served as positive control. Scale bar = 200 μm B Fluorescence intensity in organoids described in (A). At least 20 organoids were analyzed in each group. Data are presented as mean ± SD. *p < 0.05, **p < 0.01. C Rho 123 in medium. Released Rho123 in culture medium was determined as described in Methods section. Data are presented as mean ± SD. **p < 0.01. Three independent experiments were performed that presented similar results