Fig. 3

l-Arabinose modulates hepatic cholesterol synthesis and facilitates reverse cholesterol transport. Effects of l-arabinose on the relative expression of LXR, HMGCR, SREBP-1c, and SREBP2 measured by qRT-PCR analysis (A) in the liver of HFHSD-fed mice treated with or without l-arabinose for 12 weeks. Effects of l-arabinose on protein levels of SREBP-1c and HMGCR in the liver (B) with densitometric quantification (C). Expression of key genes in reverse cholesterol transport in the liver (D). The mRNA and protein expression levels were normalized to 18S and GAPDH respectively and were shown relative to mice in the control group. Data are shown as mean ± SEM. ^#p < 0.05 compared with the control group; ^##p < 0.01 compared with the control group; *p < 0.05 compared with the HFHSD-fed group. Ctrl control group, HFHSD HFHSD-fed group, HFHSD + L-Ara HFHSD-fed group treated with l-arabinose