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Fig. 6 | Nutrition & Metabolism

Fig. 6

From: l-Arabinose improves hypercholesterolemia via regulating bile acid metabolism in high-fat-high-sucrose diet-fed mice

Fig. 6

Graphical abstract of the effects of l-arabinose on improving hypercholesterolemia in HFSD-fed mice. l-Arabinose not only inhibited cholesterol synthesis but also facilitated cholesterol transport from peripheral tissue to the liver, so as to reduce circulating cholesterol. Moreover, dietary administration with l-arabinose had beneficial effects on bile acids homeostasis by reducing the reabsorption of bile acids and promoting hepatic bile acid synthesis, thus accelerating the excretion of bile acids while enhancing the decomposition of cholesterol into bile acids, ultimately facilitating cholesterol homeostasis and alleviating hypercholesterolemia. Arrows (↑) represent upregulation of protein or mRNA expression. Arrows (↓) represent downregulation

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