Table 1 Assigned metabolites detected in serum, heart, liver, kidney, cortex, hippocampus, lung, muscle, and white adipose at significantly differential levels between CR and control groups
From: Comprehensive evaluation of caloric restriction-induced changes in the metabolome profile of mice
Tissue | Metabolite | VIP | P | FC |
|---|---|---|---|---|
Serum | Palmitic acid | 1.21 | 0.00 | 0.69 |
l-Valine | 2.28 | 0.04 | 0.07 | |
l-Proline | 2.80 | 0.00 | 0.13 | |
l-Alanine | 1.20 | 0.03 | 0.79 | |
Heart | l-Alanine | 1.57 | 0.01 | 0.00 |
Hexanoic acid | 1.32 | 0.01 | 0.17 | |
l-Valine | 1.52 | 0.00 | 0.06 | |
l-Isoleucine | 1.49 | 0.01 | 0.04 | |
l-Threonine | 1.49 | 0.02 | 0.01 | |
l-Aspartic acid | 1.49 | 0.01 | 0.05 | |
l-Glutamic acid | 1.58 | 0.01 | 0.00 | |
l-Phenylalanine | 1.31 | 0.03 | 0.10 | |
d-Myo-Inositol | 1.25 | 0.00 | 0.24 | |
Adenosine | 1.26 | 0.03 | 0.10 | |
Liver | Glycine | 1.47 | 0.03 | 0.01 |
Butanedioic acid | 1.02 | 0.02 | 2.51 | |
l-Aspartic acid | 1.28 | 0.03 | 0.13 | |
d-Mannose | 1.08 | 0.02 | 0.31 | |
d-Myo-Inositol | 1.14 | 0.01 | 0.28 | |
Doconexent | 1.07 | 0.00 | 0.46 | |
Kidney | 3-Hydroxybutyric acid | 1.34 | 0.00 | 0.51 |
l-Serine | 1.62 | 0.01 | 0.23 | |
Glycerol | 2.06 | 0.00 | 0.18 | |
2-Butenedioic acid | 1.20 | 0.00 | 0.57 | |
l-Aspartic acid | 1.76 | 0.00 | 0.23 | |
l-Hydroxyproline | 1.45 | 0.02 | 0.30 | |
d-Arabinose | 1.72 | 0.00 | 0.33 | |
Oleic acid | 1.34 | 0.00 | 0.49 | |
Stearic acid | 1.01 | 0.01 | 0.64 | |
Cortex | Glycine | 2.72 | 0.03 | 5.46 |
Glycerol | 1.39 | 0.01 | 0.68 | |
Phosphoric acid | 1.82 | 0.03 | 2.45 | |
Hippocampus | l-Isoleucine | 1.70 | 0.04 | 0.23 |
l-Proline | 1.87 | 0.03 | 0.14 | |
l-Aspartic acid | 1.50 | 0.03 | 0.46 | |
Octadecanamide | 1.32 | 0.00 | 0.54 | |
Lung | Propanoic acid | 2.10 | 0.00 | 9.30 |
Morpholine | 1.55 | 0.00 | 2.17 | |
Aminomalonic acid | 1.84 | 0.00 | 5.77 | |
5-Oxoproline | 2.10 | 0.00 | 14.50 | |
Hexadecanamide | 1.78 | 0.03 | 0.07 | |
9-Octadecenamide | 2.06 | 0.00 | 0.06 | |
Muscle | l-Proline | 1.64 | 0.02 | 2.54 |
l-Aspartic acid | 1.97 | 0.04 | 0.20 | |
White adipose | Glycine | 1.61 | 0.00 | 0.10 |
Palmitic acid | 1.17 | 0.00 | 0.44 | |
Myo-Inositol | 1.12 | 0.00 | 0.48 | |
1-Monopalmitin | 1.12 | 0.00 | 0.40 | |
Glycerol monostearate | 1.19 | 0.01 | 0.32 | |
Cholesterol | 1.36 | 0.00 | 0.28 |