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Table 1 Assigned metabolites detected in serum, heart, liver, kidney, cortex, hippocampus, lung, muscle, and white adipose at significantly differential levels between CR and control groups

From: Comprehensive evaluation of caloric restriction-induced changes in the metabolome profile of mice

Tissue Metabolite VIP P FC
Serum Palmitic acid 1.21 0.00 0.69
l-Valine 2.28 0.04 0.07
l-Proline 2.80 0.00 0.13
l-Alanine 1.20 0.03 0.79
Heart l-Alanine 1.57 0.01 0.00
Hexanoic acid 1.32 0.01 0.17
l-Valine 1.52 0.00 0.06
l-Isoleucine 1.49 0.01 0.04
l-Threonine 1.49 0.02 0.01
l-Aspartic acid 1.49 0.01 0.05
l-Glutamic acid 1.58 0.01 0.00
l-Phenylalanine 1.31 0.03 0.10
d-Myo-Inositol 1.25 0.00 0.24
Adenosine 1.26 0.03 0.10
Liver Glycine 1.47 0.03 0.01
Butanedioic acid 1.02 0.02 2.51
l-Aspartic acid 1.28 0.03 0.13
d-Mannose 1.08 0.02 0.31
d-Myo-Inositol 1.14 0.01 0.28
Doconexent 1.07 0.00 0.46
Kidney 3-Hydroxybutyric acid 1.34 0.00 0.51
l-Serine 1.62 0.01 0.23
Glycerol 2.06 0.00 0.18
2-Butenedioic acid 1.20 0.00 0.57
l-Aspartic acid 1.76 0.00 0.23
l-Hydroxyproline 1.45 0.02 0.30
d-Arabinose 1.72 0.00 0.33
Oleic acid 1.34 0.00 0.49
Stearic acid 1.01 0.01 0.64
Cortex Glycine 2.72 0.03 5.46
Glycerol 1.39 0.01 0.68
Phosphoric acid 1.82 0.03 2.45
Hippocampus l-Isoleucine 1.70 0.04 0.23
l-Proline 1.87 0.03 0.14
l-Aspartic acid 1.50 0.03 0.46
Octadecanamide 1.32 0.00 0.54
Lung Propanoic acid 2.10 0.00 9.30
Morpholine 1.55 0.00 2.17
Aminomalonic acid 1.84 0.00 5.77
5-Oxoproline 2.10 0.00 14.50
Hexadecanamide 1.78 0.03 0.07
9-Octadecenamide 2.06 0.00 0.06
Muscle l-Proline 1.64 0.02 2.54
l-Aspartic acid 1.97 0.04 0.20
White adipose Glycine 1.61 0.00 0.10
Palmitic acid 1.17 0.00 0.44
Myo-Inositol 1.12 0.00 0.48
1-Monopalmitin 1.12 0.00 0.40
Glycerol monostearate 1.19 0.01 0.32
Cholesterol 1.36 0.00 0.28
  1. FC, fold change (caloric restriction to control); VIP, variable importance in projection