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Table 2 The relationship between dietary factors and biliary diseases

From: The role of diet and nutrition related indicators in biliary diseases: an umbrella review of systematic review and meta-analysis

First author, Year

No. of included studies

Type of study

Dietary factor (Subgroup or Dose response)

Effects model

MA metric

Estimates

95%CI

Test for overall effect (p-value)

I2% (p-value)

Egger test (p-value)

Publication bias and small-study effect

Gallbladder cancer

Chen [29]

6

Case–control

All spicy food

random

OR

1.78

(0.83–3.83)

NA

75 (0.001)

0.714

No publication bias

Chen [29]

6

Case–control

Chili pepper

random

OR

1.78

(0.83–3.83)

NA

75 (0.001)

0.714

No publication bias

ZHU [22]

6

Case–control(4);Cohort(2)

Tea

random

OR

0.67

(0.40–1.12)

0.13

82 (< 0.0001)

Only funnel plot (N)

No publication bias

ZHU [22]

4

Case–control(3);Cohort(1)

Tea (highest vs. lowest/none)

random

OR

0.57

(0.25–1.29)

0.18

82 (0.001)

Only funnel plot (N)

No publication bias

ZHU [22]

4

Case–control(3);Cohort(1)

Tea (moderate vs. low/none)

random

OR

0.62

(0.33–1.14)

0.12

77 (0.004)

Only funnel plot (N)

No publication bias

Biliary tract cancer

Godos [13]

8

Total Cohort(5);Case–control(3)

Coffee

random

OR

0.83

(0.64–1.08)

NA

0 (0.58)

Only funnel plot (N)

No publication bias

Godos [13]#

5

Cohort(5)

Coffee

random

OR

0.74

(0.34–1.63)

NA

0 (0.82)

Only funnel plot (N)

No publication bias

Godos [13]#

3

Case–control(3)

Coffee

random

OR

0.84

(0.61–1.15)

NA

22 (0.27)

Only funnel plot (N)

No publication bias

Xiong [36]

8

Total Case–control(5);Cohort(3)

Tea

random

RR

0.66

(0.48–0.85)

NA

81.1 (0.000)

 > 0.05

No publication bias

Xiong [36]#

3

Cohort

Tea

random

RR

0.62

(0.44–0.80)

NA

55.8 (0.009)

 > 0.05

No publication bias

Xiong [36]#

5

Case–control

Tea

random

RR

0.84

(0.77–0.90)

NA

60 (0.001)

 > 0.05

No publication bias

Xiong [36]

8

Total Case–control(5);Cohort(3)

Tea (every 1cup/day increment)

–

RR

0.96

(0.93–0.98)

0.001

NA

 > 0.05

No publication bias

Huai [37]

10

Total Case–control(8);Cohort(1); Nested case–control(1)

Vegetable

random

RR

0.48

(0.22–0.74)

NA

86.8 (0.000)

0.84

No publication bias

Huai [37]#

8

Case–control

Vegetable

random

RR

0.45

(0.14–0.75)

NA

88 (< 0.001)

0.84

No publication bias

Huai [37]#

1

Cohort

Vegetable

–

RR

0.96

(0.37–1.55)

NA

–

0.84

No publication bias

Huai [37]#

1

Nested case–control

Vegetable

–

RR

0.40

(0.23–0.76)

NA

–

0.84

No publication bias

Huai [37]

8

Case–control(6);Cohort(1); Nested case–control(1)

Vegetable (every 100 g/day increment)

–

RR

0.31

(0.20–0.47)

 < 0.001

NA

0.84

No publication bias

Huai [37]

13

Total Case–control(11);Cohort(1); Nested case–control(1)

Fruit

random

RR

0.47

(0.32–0.61)

NA

63.3 (0.001)

0.64

No publication bias

Huai [37]#

11

Case–control

Fruit

random

RR

0.41

(0.26–0.56)

NA

61.6 (0.004)

0.64

No publication bias

Huai [37]#

1

Cohort

Fruit

–

RR

0.87

(0.47–1.27)

NA

–

0.64

No publication bias

Huai [37]#

1

Nested case–control

Fruit

–

RR

0.60

(0.33–0.98)

NA

–

0.64

No publication bias

Huai [37]

8

Case–control(6);Cohort(1); Nested case–control(1)

Fruit (every 100 g/day increment)

–

RR

0.89

(0.66–1.18)

0.35

NA

0.64

No publication bias

Kamsa-ard [30]

3

Case–control

Raw Fish

fixed

OR

2.54

(1.94–3.35)

 < 0.00001

0 (0.80)

NA

NA

Kamsa-ard [30]

2

Case–control

Fermented Fish

fixed

OR

1.61

(0.76–3.41)

0.21

45 (0.18)

NA

NA

Kamsa-ard [30]

3

Case–control

Glutinous Rice

fixed

OR

1.30

(0.85–2.01)

0.23

62 (0.07)

NA

NA

Kamsa-ard [30]

2

Case–control

Meat

random

OR

1.03

(0.57–1.85)

0.92

59 (0.06)

NA

Na

Kamsa-ard [30]

3

Case–control

Betel nut

fixed

OR

1.45

(0.69–3.02)

0.33

60 (0.06)

NA

NA

Steele [23]

3

Total Case–control(2)

Nested case–control(1)

Fermented Meats

random

OR

1.81

(0.96–3.39)

0.066

17 (0.28)

NA

NA

Steele [23]

5

Total Case–control(3)

Nested case–control(2)

High Nitrate Foods

random

OR

1.41

(1.05–1.91)

0.024

46 (0.01)

NA

NA

Steele [23]

2

Case–control

Rice

random

OR

0.88

(0.48–1.63)

0.688

34 (0.22)

NA

NA

Cholecystolithiasis/gallbladder diease

Zhang [39]

7

Cohort

Coffee

random

RR

0.83

(0.76–0.89)

NA

35.9 (0.154)

0.39

No publication bias

Zhang [39]

4

Cohort

Coffee (every 1Cup/Day increment)

–

RR

0.95

(0.91–1.00)

0.049

54.4 (0.019)

0.39

No publication bias

Zhang [40]

14

Total Case–control(4);Cohort(9);Cross sectional(1)

Vegetables

random

RR

0.83

(0.74–0.94)

NA

82.5 (0.000)

0.682

No publication bias

Zhang [40]#

9

Cohort

Vegetables

random

RR

0.92

(0.82–1.02)

NA

80.2 (0.001)

0.682

No publication bias

Zhang [40]#

4

Case–control

Vegetables

random

RR

0.39

(0.24–0.62)

NA

59.8 (0.058)

0.682

No publication bias

Zhang [40]#

1

Cross sectional

Vegetables

random

RR

0.92

(0.80–1.07)

NA

–

0.682

No publication bias

Zhang [40]

6

Cohort

Vegetables(every 200 g/Day increment)

–

RR

0.96

(0.93–0.98)

0.001

NA

0.682

No publication bias

Zhang [40]

5

Cohort

Fruits

random

RR

0.88

(0.83–0.92)

NA

0 (0.456)

0.735

No publication bias

Zhang [40]

4

Cohort

Fruits (every 200 g/Day increment)

–

RR

0.97

(0.96–0.98)

 

NA

0.735

No publication bias

  1. #: Subgroup analysis of the different study design types of the corresponding study