Table 6 AMSTAR2 and GRADE classification of the evidence
Summary of findings | Certainty assessment(degradation factor) | Certainty assessment (Escalation factors) | Importance | Grade | AMSTAR2 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
First author, Year | Dietary and nutrition related factor | Study design(number) | Outcome | Relative effect (95% CI) | Risk of bias | Inconsistency | Indirectness | Imprecision | Publication bias | Large effect | Plausible confounding | Dose response gradient | |||
Chen [19] | All spicy food | Case–control(6) | Gallbladder cancer | OR 1.78 (0.83–3.83) | Seriouse | Seriousf | Not serious | Seriousg | Undetected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Chen [19] | Chili pepper | Case–control(6) | Gallbladder cancer | OR 1.78 (0.83–3.83) | Seriouse | Seriousf | Not serious | Seriousg | Undetected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
ZHU [20] | Tea | Case–control(4);Cohort(2) | Gallbladder cancer | OR 0.67 (0.40–1.12) | Seriouse | Seriousf | Not serious | Seriousg | Undetected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
ZHU [20] | Tea (highest vs. lowest/none) | Case–control(3);Cohort(1) | Gallbladder cancer | OR 0.57 (0.25–1.29) | Seriouse | Seriousf | Not serious | Seriousg | Undetected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
ZHU [20] | Tea (moderate vs. low/none) | Case–control(3);Cohort(1) | Gallbladder cancer | OR 0.62 (0.33–1.14) | Seriouse | Seriousf | Not serious | Seriousg | Undetected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Godos [8] | Coffee | Cohort(5);Case–control(3) | Biliary tract cancer | OR 0.83 (0.64–1.08) | Not serious | Not serious | Not serious | Seriousg | Undetected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Low |
Xiong [21] | Tea | Case–control(5);Cohort(3) | Biliary tract cancer | RR 0.66 (0.48–0.85) | Seriouse | Seriousf | Not serious | Not serious | Undetected | No | No | Yes | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Xiong [21] | Tea (every 1cup/day increment) | Case–control(5);Cohort(3) | Biliary tract cancer | RR 0.96 (0.93–0.98) | Seriouse | Seriousf | Not serious | Not serious | Undetected | No | No | Yes | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Huai [22] | Vegetable | Case–control(8);Cohort(1); Nested case–control(1) | Biliary tract cancer | RR 0.48 (0.22–0.74) | Not serious | Seriousf | Not serious | Not serious | Undetected | Yes | No | Yes | 7-Critical | ⨁⨁⨁◯ Moderate | Critically low |
Huai [22] | Vegetable (every 100 g/day increment) | Case–control(6);Cohort(1); Nested case–control(1) | Biliary tract cancer | RR 0.31 (0.20–0.47) | Not serious | Seriousf | Not serious | Not serious | Undetected | Yes | No | Yes | 7-Critical | ⨁⨁⨁◯ Moderate | Critically low |
Huai [22] | Fruit | Case–control(11);Cohort(1); Nested case–control(1) | Biliary tract cancer | RR 0.47 (0.32–0.61) | Not serious | Seriousf | Not serious | Not serious | Undetected | Yes | No | No | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Huai [22] | Fruit (every 100 g/day increment) | Case–control(6);Cohort(1); Nested case–control(1) | Biliary tract cancer | RR 0.89 (0.66–1.18) | Not serious | Seriousf | Not serious | Seriousg | Undetected | No | No | Yes | 6-Important | ⨁◯◯◯ Very low | Critically low |
Kamsa-ard [23] | Raw Fish | Case–control(3) | Biliary tract cancer | OR 2.54 (1.94–3.35) | Seriouse | Not serious | Not serious | Not serious | Strongly suspected | Yes | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Kamsa-ard [23] | Fermented Fish | Case–control(2) | Biliary tract cancer | OR 1.61 (0.76–3.41) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Kamsa-ard [23] | Glutinous Rice | Case–control(3) | Biliary tract cancer | OR 1.3 (0.85–2.01) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Kamsa-ard [23] | Meat | Case–control(2) | Biliary tract cancer | OR 1.03 (0.57–1.85) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Kamsa-ard [23] | Betel nut | Case–control(3) | Biliary tract cancer | OR 1.45 (0.69–3.02) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Steele [24] | Fermented Meats | Total case–control(2) @Nested case–control(1) | Biliary tract cancer | OR 1.81 (0.96–3.39) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Steele [24] | High Nitrate Foods | Total case–control(3) @Nested case–control(2) | Biliary tract cancer | OR 1.41 (1.05–1.91) | Seriouse | Seriousf | Not serious | Not serious | Strongly suspected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Steele [24] | Rice | Case–control(2) | Biliary tract cancer | OR 0.88 (0.48–1.63) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Zhang [28] | Coffee | Cohort(7) | Cholecystolithiasis/gallbladder diease | RR 0.83 (0.76–0.89) | Not serious | Not serious | Not serious | Not serious | Undetected | No | No | Yes | 7-Critical | ⨁⨁⨁◯ Moderate | Critically low |
Zhang [28] | Coffee (every 1Cup/Day increment) | Cohort(4) | Cholecystolithiasis/gallbladder diease | RR 0.95 (0.91–1.00) | Not serious | Seriousf | Not serious | Not serious | Undetected | No | No | Yes | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Zhang [29] | Vegetables | Case–control(4);Cohort(9); @Cross sectional(1) | Cholecystolithiasis/gallbladder diease | RR 0.83 (0.74–0.94) | Not serious | Seriousf | Not serious | Not serious | Undetected | No | No | Yes | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Zhang [29] | Vegetables(every 200 g/Day increment) | Cohort(6) | Cholecystolithiasis/gallbladder diease | RR 0.96 (0.93–0.98) | Not serious | Seriousf | Not serious | Not serious | Undetected | No | No | Yes | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Zhang [29] | Fruits | Cohort(5) | Cholecystolithiasis/gallbladder diease | RR 0.88 (0.83–0.92) | Not serious | Not serious | Not serious | Not serious | Undetected | No | No | Yes | 7-Critical | ⨁⨁⨁◯ Moderate | Critically low |
Zhang [29] | Fruits (every 200 g/Day increment) | Cohort(4) | Cholecystolithiasis/gallbladder diease | RR 0.97 (0.96–0.98) | Not serious | Not serious | Not serious | Not serious | Undetected | No | No | Yes | 7-Critical | ⨁⨁⨁◯ Moderate | Critically low |
Gu [17] | Type 2 DM | Case–control(8); Cohort(12) | Gallbladder cancer | RR 1.56 (1.36–1.79) | Not serious | Seriousf | Not serious | Not serious | Strongly suspected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Li [18] | Overweight | Case–control(8); Cohort(9) | Gallbladder cancer | RR 1.17 (1.07–1.28) | Not serious | Seriousf | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Li [18] | Obesity | Case–control(9); Cohort(13) | Gallbladder cancer | RR 1.62 (1.49–1.75) | Not serious | Not serious | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Li [18] | Overweight | Case–control(4); Cohort(4) | Biliary tract cancer-eCCA | RR 1.26 (1.14–1.39) | Not serious | Not serious | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Li [18] | Obesity | Case–control(9); Cohort(7) | Biliary tract cancer-eCCA | RR 1.48 (1.21–1.81) | Not serious | Seriousf | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Petrick [25] | Obesity | Nested case–control(3); Cohort(1) | Biliary tract cancer-iCCA | RR 1.49 (1.32–1.70) | Not serious | Not serious | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Petrick [25] | DM | Nested case–control(4); Cohort(2) | Biliary tract cancer-iCCA | RR 1.53 (1.31–1.78) | Not serious | Seriousf | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Aune [31] | DM | Cohort(10) | Cholecystolithiasis/gallbladder diease | RR 1.56 (1.26–1.93) | Not serious | Seriousf | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Low |
Barclay [30] | Glycemic index rate (highest vs. lowest) | Cohort(2) | Cholecystolithiasis/gallbladder diease | RR 1.26 (1.13–1.40) | Seriouse | Seriousf | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Barclay [30] | Glycemic load rate (highest vs. lowest) | Cohort(2) | Cholecystolithiasis/gallbladder diease | RR 1.41 (1.25–1.60) | Seriouse | Seriousf | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Dagfinn Aune [32] | Every 5 unit increment of BMI | Cohort(17) | Cholecystolithiasis/gallbladder diease | RR 1.63 (1.49–1.78) | Not serious | Seriousf | Not serious | Not serious | Undetected | No | No | Yes | 7-Critical | ⨁⨁◯◯ Low | Low |
Dagfinn Aune [32] | Every 10 cm increment of waist circumference | Cohort(5) | Cholecystolithiasis/gallbladder diease | RR 1.46 (1.24–1.72) | Not serious | Seriousf | Not serious | Not serious | Strongly suspected | No | No | Yes | 7-Critical | ⨁◯◯◯ Very low | Low |
Dagfinn Aune [32] | Every 0.1 unit increment in waist-to-hip ratio | Cohort(4) | Cholecystolithiasis/gallbladder diease | RR 1.44 (1.26–1.64) | Not serious | Seriousf | Not serious | Not serious | Strongly suspected | No | No | Yes | 7-Critical | ⨁◯◯◯ Very low | Low |
Daniel [33] | Triglycerides | Cohort(2) | Cholecystolithiasis/gallbladder diease | OR 1.1 (0.99–1.22) | Not serious | Not serious | Not serious | Not serious | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Daniel [33] | HDL cholesterol | Cohort(2) | Cholecystolithiasis/gallbladder diease | OR 0.87 (0.62–1.23) | Not serious | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Daniel [33] | Non-HDL cholesterol | Cohort(2) | Cholecystolithiasis/gallbladder diease | OR 1.19 (1.07–1.32) | Not serious | Seriousf | Not serious | Not serious | Strongly suspected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Ying Li [50] | Alcohol(drinker vs. non-drinker) | Case–control(2) | Gallbladder cancer | OR 0.7 @99%CI(0.49–1.00) | Seriouse | Not serious | Not serious | Not serious | Strongly suspected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee, 2019 [35] | Alcohol(>0–0.5 vs. 0 drink/d)a | Cohort(26) | Gallbladder cancer | HR 1.07 (0.91–1.26) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee, 2019 [35] | Alcohol(>0.5–1 vs. 0 drink/d)a | Cohort(26) | Gallbladder cancer | HR 1.1 (0.87–1.39) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(1–<3 vs. 0 drink/d)a | Cohort(26) | Gallbladder cancer | HR 0.94 (0.74–1.21) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(3–<5, vs. 0 drink/d)a | Cohort(26) | Gallbladder cancer | HR 1.16 (0.69–1.94) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(>5 vs. 0 drink/d)a | Cohort(26) | Gallbladder cancer | HR 2.39 (0.63–9.12) | Seriouse | Seriousf | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(every 1drink/d increment)a | Cohort(26) | Gallbladder cancer | HR 0.98 (0.92–1.05) | Seriouse | Not serious | Not serious | Not serious | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Bagnardi [16] | Alcohol (Light vs. none)c | Case–control(4);Cohort(4) | Gallbladder cancer | RR 1.23 (0.84 − 1.83) | Not serious | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Bagnardi [16] | Alcohol (Moderate vs. none)c | Case–control(4);Cohort(4) | Gallbladder cancer | RR 0.88 (0.68 − 1.13) | Not serious | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Bagnardi [16] | Alcohol (Heavy vs. none)c | Case–control(4);Cohort(4) | Gallbladder cancer | RR 2.64 (1.62 − 4.30) | Not serious | Not serious | Not serious | Not serious | Strongly suspected | Yes | No | No | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Ying Li [50] | Alcohol(drinker vs. non-drinker) | Case–control(2) | Biliary tract cancer-eCCA | OR 1.14 99%CI(0.75–1.75) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Ying Li [50] | Alcohol(drinker vs. non-drinker) | Case–control(2) | Biliary tract cancer-VPC | OR 0.68 99%CI(0.20–2.37) | Seriouse | Seriousf | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(> 0–0.5 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 0.79 (0.62–1.00) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(> 0.5–1 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 0.91 (0.65–1.26) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(1– < 3 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 0.98 (0.73–1.31) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(3– < 5, vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 1.25 (0.77–2.02) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(> 5 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 2.35 (1.46–3.78) | Seriouse | Not serious | Not serious | Not serious | Strongly suspected | Yes | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(every 1drink/d increment)a | Cohort(26) | Biliary tract cancer | HR 1.03 (1.01–1.06) | Seriouse | Not serious | Not serious | Not serious | Strongly suspected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(> 0–0.5 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 0.87 (0.68–1.12) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(> 0.5–1 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 1.14 (0.82–1.58) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(1– < 3 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 1.08 (0.74–1.58) | Seriouse | Seriousf | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(3– < 5, vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 1.82 (0.98–3.39) | Seriouse | Seriousf | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(> 5 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 1.02 (0.64–1.62) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(every 1drink/d increment)b | Cohort(26) | Biliary tract cancer | HR 1.03 (0.98–1.08) | Seriouse | Not serious | Not serious | Not serious | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(> 0–0.5 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 1.08 (0.80–1.45) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(> 0.5–1 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 0.99 (0.69–1.41) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(1– < 3 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 1.33 (0.99–1.80) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(3– < 5, vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 1.16 (0.66–2.01) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(> 5 vs. 0 drink/d)a | Cohort(26) | Biliary tract cancer | HR 1.59 (0.85–2.98) | Seriouse | Not serious | Not serious | Seriousg | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Emma E. McGee [35] | Alcohol(every 1drink/d increment)a | Cohort(26) | Biliary tract cancer | HR 1 (0.95–1.04) | Seriouse | Not serious | Not serious | Not serious | Strongly suspected | No | No | No | 6-Important | ⨁◯◯◯ Very low | Critically low |
Xiao-Hua Ye [51] | Alcohol(drinker vs. non-drinker) | Case–control(6);Cohort(1) | Biliary tract cancer-eCCA | RR 1.09 (0.87–1.37) | Not serious | Not serious | Not serious | Seriousg | Undetected | No | No | No | 6-Important | ⨁⨁◯◯ Low | Critically low |
Clements [1] | Alcohol(drinker vs. non-drinker) | Case–control(15) | Biliary tract cancer-iCCA | OR 3.15 (2.24–4.41) | Not serious | Seriousf | Not serious | Not serious | Undetected | Yes | No | No | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Clements [1] | Alcohol(drinker vs. non-drinker) | Case–control(11) | Biliary tract cancer-eCCA | OR 1.75 (1.20–2.55) | Not serious | Seriousf | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Jiantao Wang [52] | Alcohol(highest vs. lowest) | Case–control(10);Cohort(8) | Cholecystolithiasis/gallbladder diease | RR 0.62 (0.49–0.78) | Not serious | Seriousf | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Jiantao Wang | Alcohol(types of drink beer highest vs. lowest)b | Case–control(1); Cohort(2) | Cholecystolithiasis/gallbladder diease | RR 0.64 (0.52–0.78) | Not serious | Not serious | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Jiantao Wang [52] | Alcohol(types of drink wine highest vs. lowest)b | Case–control(1); Cohort(2) | Cholecystolithiasis/gallbladder diease | RR 0.72 (0.54–0.96) | Not serious | Not serious | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Jiantao Wang [52] | Alcohol(types of drink liquor highest vs. lowest)b | Cohort(2) | Cholecystolithiasis/gallbladder diease | RR 0.71 (0.64–0.85) | Not serious | Not serious | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Byung [27] | Alcohol (drinker vs. non-drinker) | Case–control(14);Cohort(9) | Cholecystolithiasis/gallbladder diease | RR 0.84 (0.79–0.89) | Not serious | Seriousf | Not serious | Not serious | Strongly suspected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |
Byung [27] | Alcohol (Light vs. none)d | Case–control(5);Cohort(6) | Cholecystolithiasis/gallbladder diease | RR 0.96 (0.94–0.99) | Not serious | Not serious | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Byung [27] | Alcohol (Moderate vs. none)d | Case–control(8);Cohort(6) | Cholecystolithiasis/gallbladder diease | RR 0.8 (0.75–0.85) | Not serious | Not serious | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁⨁◯◯ Low | Critically low |
Byung [27] | Alcohol (Heavy vs. none)d | Case–control(8);Cohort(6) | Cholecystolithiasis/gallbladder diease | RR 0.66 (0.56–0.79) | Not serious | Seriousf | Not serious | Not serious | Undetected | No | No | No | 7-Critical | ⨁◯◯◯ Very low | Critically low |