Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study

Li, Ping; Chen, Yuhui; Song, Jieyun; Yan, Lailai; Tang, Tiantian; Wang, Rui; Fan, Xiuqin; Zhao, Yurong; Qi, Kemin

doi:10.1186/s12986-022-00683-3

Table 5 Interactions between maternal DHA-rich n-3 PUFAs supplementation and the genotypes of SNPs on the profiles of PUFAs in the colostrum (P_interaction)

From: Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study

Gene	SNPs	n-6 PUFAs			n-3 PUFAs						n-6/n-3 ΣPUFAs
Gene	SNPs	LA	AA	AA/LA	ALA	EPA	DHA	EPA/ALA	DHA/ALA	DHA/EPA	n-6/n-3 ΣPUFAs
Fads1	rs174448	0.001	0.322	0.434	0.067	0.039	0.034	0.549	0.004	0.010	0.156
	rs174537	0.821	0.749	0.743	0.254	0.712	0.166	0.510	0.384	0.377	0.617
	rs174550	0.622	0.495	0.545	0.967	0.268	0.240	0.650	0.928	0.800	0.222
	rs174553	0.042	0.825	0.314	0.766	0.140	0.659	0.519	0.701	0.841	0.006
Fads2	rs174598	0.007	0.498	0.523	0.906	0.044	0.002	0.124	0.110	0.083	0.002
	rs174602	0.080	0.844	0.422	0.749	0.117	0.030	0.612	0.991	0.177	0.520
	rs174609	0.467	0.014	0.860	0.278	0.592	0.834	0.513	0.725	0.854	0.634
	rs174619	0.736	0.736	0.893	0.196	0.516	0.129	0.102	0.004	0.450	0.840
	rs498793	0.202	0.574	0.598	0.512	0.821	0.975	0.551	0.828	0.186	0.234
	rs3168072	0.435	0.069	0.988	0.318	0.846	0.298	0.994	0.223	0.492	0.461
Fads3	rs174455	0.074	0.864	0.817	0.824	0.217	0.399	0.748	0.989	0.162	0.129
	rs174464	0.005	0.907	0.757	0.811	0.878	0.746	0.872	0.423	0.668	0.003
	rs76996928	< 0.001	0.730	0.275	0.686	0.342	0.208	0.946	0.169	0.551	0.001
Elovl2	rs1323739	0.473	0.874	0.631	0.986	0.250	0.764	0.952	0.932	0.978	0.212
	rs2295602	0.976	0.491	0.819	0.185	0.206	0.687	0.357	0.356	0.505	0.510
	rs2180725	0.510	0.517	0.962	0.597	0.222	0.678	0.729	0.798	0.795	0.206
	rs3798710	0.427	0.709	0.654	0.341	0.287	0.510	0.583	0.484	0.789	0.142
	rs78793420	0.540	0.701	0.689	0.709	0.390	0.882	0.481	0.890	0.657	0.477
Elovl5	rs209512	0.264	0.931	0.213	0.021	0.732	0.106	0.047	0.268	0.712	0.941
	rs2281274	0.757	0.555	0.479	0.771	0.991	0.553	0.644	0.443	0.323	0.826
	rs2294852	0.639	0.441	0.992	0.726	0.314	0.968	0.791	0.735	0.445	0.346
	rs2397142	0.722	0.403	0.871	0.706	0.751	0.660	0.357	0.504	0.955	0.454
	rs6909592	0.949	0.524	0.650	0.711	0.306	0.445	0.500	0.412	0.535	0.449
	rs9349665	0.482	0.933	0.560	0.906	0.222	0.787	0.304	0.595	0.867	0.238
	rs9395858	0.252	0.801	0.795	0.844	0.279	0.889	0.227	0.794	0.698	0.177
	rs12207094	0.071	0.314	0.531	0.057	0.746	0.149	0.105	0.383	0.757	0.731

SNPs Single nucleotide polymorphisms, Fads Fatty acid desaturases, Elovl Elongase of long chain fatty acid, PUFAs Polyunsaturated fatty acids, LA Linoleic acid, AA Arachidonic acid, ALA α-Linolenic acid, EPA Eicosapentaenoic acid, DHA Docosahexaenoic acid

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ISSN: 1743-7075

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