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Table 4 Effect of taurine supplementation on oxidative stress and inflammatory markers

From: Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial

Variable

Taurine group (n = 60)

Placebo group (n = 60)

MD (95% CI), P-value

TAC (mmol/L)

 Before

126.85 ± 39.82

131.36 ± 38.83

4.5 (−18.86 to 8.79), 0.531a

 After

192.61 ± 91.77

147.52 ± 107.12

45 (9. 6 to 81.1), 0.015b

 MD (95% CI), P-valuec

65.73 (41.7 to 88.8), 0.001

16.54 (−11.7 to 44.7), 0.256

 

MDA (nmol/mL)

 Before

170.79 ± 61.47

183.38 ± 125.08

−12.20 (–48.7 to 12.33), 0.485a

 After

129.61 ± 109.60

172.46 ± 128.19

−43.6 (−83.7 to −3.57), 0.033b

 MD (95% CI), P-valuec

−41.70 (−69.6 to −11.74), 0.007

−10.29 (−32.9 to 24.4), 0.614

 

HsCRP (mg/dL)

 Before

3.17 ± 1.88

3.01 ± 1.79

0.41 (−0.55 to 0.85), 0.642a

 After

1.87 ± 2.08

3.66 ± 3.17

1.76 (−2.7 to −0.88), 0.001b

 MD (95% CI), P-valuec

−1.29 (−2.6 to −0.54), 0.001

−0.64 (−0.50 to 1.25), 0.157

 

TNF-alpha (ng/ml)

 Before

33.18 ± 25.27

30.90 ± 24.53

2.28 (−6.66 to 10.45), 0.616a

 After

14.42 ± 10.50

25.82 ± 26.27

11.01 (−18.3 to −4.3), 0.002b

 MD (95% CI), P-valuec

−18.74 (−20.6 to −11.87), 0.001

−5.07 (−14.50 to 420), 0.291

 
  1. Significant results are shown in bold type ( P < 0.05)
  2. Hs-CRP: high-sensitivity C-reactive protein, MDA: malondialdehyde, TAC: total antioxidant capacity
  3. Values are expressed as mean (SD)
  4. aIndependent samples t-test
  5. bAdjusted for baseline values, weight, and calorie intake using the analysis of covariance (ANCOVA) test
  6. cPaired-samples t-test