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Table 5 The Effects of taurine supplementation on biomarkers of endothelial markers

From: Protective and therapeutic effectiveness of taurine supplementation plus low calorie diet on metabolic parameters and endothelial markers in patients with diabetes mellitus: a randomized, clinical trial

Variable

Taurine group (n = 60)

Placebo group (n = 60)

MD (95% CI), P-value

VCAM (µg.ml)

 Before

3.14 ± 0.94

3.82 ± 1.25

0.68 (−1.86 to 0.45), 0.230a

 After

2.10 ± 0.08

3.68 ± 1.15

−1.67 (−2. 7 to −0.7), 0.001b

 MD (95% CI), P-valuec

−1.12 (−1.81 to −0.43), 0.002

−0.14 (−0.4 to 0.13), 0.321

 

ICAM (ng/mL)

 Before

81.22 ± 11.64

79.15 ± 9.84

2.2 (–1.7 to 5.33), 0.294a

 After

68.5 ± 12.25

76.2 ± 14.62

−7.6 (−14.7 to −0.88), 0.029b

 MD (95% CI), P-valuec

−12.1 (−18.6 to −6.74), 0.001

−2.49 (−5.9 to 0.1), 0.054

 

E Selectin (mg/L)

 Before

82.42 ± 18.27

79.2 ± 24.53

3.27(−1.66 to 3.77), 0.153a

 After

71.57 ± 14.50

77.01 ± 26.27

−6.1 (−11.3 to −0.68), 0.028b

 MD (95% CI), P-valuec

−10.94 (−17.6 to −2.87), 0.002

−1.51 (−5.50 to 0.20), 0.081

 

MMP-9 (ng.ml.)

 Before

193.65 ± 55.99

179 ± 495.46

14.6(−7.2 to 38.45), 0.193a

 After

140.23 ± 49.82

160.55 ± 385.85

−20.1 (−38.3 to −0.98), 0.049

 MD (95% CI), P-valuec

−53.18 (−0.8 to −28.17), 0.001

−19.1 (−1.50 to 0.20), 0.053

 
  1. Significant results are shown in bold type ( P < 0.05)
  2. VCAM: vascular cell adhesion molecule, ICAM: Intercellular Adhesion Molecule 1, MMP-9: Matrix metallopeptidases
  3. Values are expressed as mean (SD)
  4. aIndependent samples t-test
  5. bAdjusted for baseline values and, duration of diabetes, and energy intake changes using the analysis of covariance (ANCOVA) test
  6. cPaired-samples t-test