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Fig. 3 | Nutrition & Metabolism

Fig. 3

From: Salvianolic acid B activates chondrocytes autophagy and reduces chondrocyte apoptosis in obese mice via the KCNQ1OT1/miR-128-3p/SIRT1 signaling pathways

Fig. 3

Sal B promotes chondrocyte autophagy, and reduces PA-induced apoptosis and inflammation. A Viability of ATDC5 cells was detected by MTT assay following the treatment of different concentrations of Sal B for 24 h. B Cell viability was measured in cells treated with Sal B (25 μM, 50 μM or 100 μM) followed by the treatment of PA (500 μM, 24 h). C–E Concentrations of pro-inflammatory cytokines in the culture supernatant, F and G Apoptotic ratio, H and I expression levels of apoptosis-related proteins, and J and K expression levels of autophagy-related proteins were assayed, after ATDC5 cells were in turn treated with Sal B (50 μM or 100 μM) for 24 h, and 500 μM PA for another 24 h. n = 3. Data are expressed as means ± SEM. One-way ANOVA was used for the comparison in this study. *P < 0.05

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