Table 3 Correlation between different modules and therapeutic effect of TCM

Module yellow; number of molecules = 10

case/total

15/22

10/22

10/23

8/23

Model 1

1

0.341 (0.096, 1.217)

0.279 (0.076, 1.025)

0.215 (0.058, 0.787)

0.003 (0.000, 0.282)

Model 2

1

0.290 (0.077, 1.083)

0.234 (0.060, 0.911)

0.212 (0.056, 0.810)

0.003 (0.000, 0.282)

Module green; number of molecules = 8

Case/total

15/22

12/22

10/23

6/23

Model 1

1

0.473 (0.130, 1.715)

0.374 (0.107, 1.307)

0.124 (0.031, 0.492)

0.002 (0.000, 0.133)

Model 2

1

0.537 (0.140, 2.056)

0.344 (0.096, 1.234)

0.118 (0.028, 0.505)

0.001 (0.000, 0.110)

Module turquoise; number of molecules = 40

Case/total

8/22

12/22

13/23

10/23

Model 1

1

1.954 (0.549, 6.956)

2.513 (0.720, 8.771)

1.225 (0.354, 4.236)

1.500 (0.026, 86.403)

Model 2

1

1.689 (0.452, 6.319)

3.080 (0.832, 11.398)

1.406 (0.391, 5.050)

2.721 (0.042, 176.870)

Module red; number of molecules = 6

Case/total

9/22

11/22

13/23

10/23

Model 1

1

1.376 (0.407, 4.653)

1.614 (0.475, 5.482)

0.853 (0.244, 2.991)

2.390 (0.040, 141.941)

Model 2

1

1.319 (0.351, 4.952)

1.476 (0.410, 5.307)

0.455 (0.111, 1.862)

0.453 (0.005, 40.559)

Module brown; number of molecules = 13

Case/total

10/22

12/22

11/23

10/23

Model 1

1

1.599 (0.455, 5.616)

1.021 (0.299, 3.489)

0.777 (0.223, 2.712)

0.135 (0.002, 9.505)

Model 2

1

1.615 (0.434, 6.005)

0.736 (0.204, 2.659)

0.672 (0.181, 2.491)

0.069 (0.001, 6.060)

Module blue; number of molecules = 20

Case/total

9/22

12/22

12/23

10/23

Model 1

1

2.103 (0.600, 7.370)

1.648 (0.472, 5.754)

1.086 (0.319, 3.692)

4.102 (0.072, 232.322)

Model 2

1

2.097 (0.579, 7.592)

1.520 (0.421, 5.496)

1.091 (0.310, 3.838)

3.931 (0.060, 256.329)

Module black; number of molecules = 6

Case/total

11/22

9/22

11/23

12/23

Model 1

1

0.779 (0.224, 2.706)

0.934 (0.269, 3.242)

0.995 (0.295, 3.357)

1.302 (0.023, 74.558)

Model 2

1

0.837 (0.230, 3.036)

1.011 (0.274, 3.732)

0.958 (0.273, 3.361)

0.804 (0.012, 52.620)