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Table 3 Association of ischemic and hemorrhagic stroke with rs12514417 based on alcohol intake

From: ALDH7A1 rs12514417 polymorphism may increase ischemic stroke risk in alcohol-exposed individuals

 

Ischemic stroke

Hemorrhagic stroke

No alcohol intake

Alcohol intake

No alcohol intake

Alcohol intake

 

OR

(95% CI)

OR

(95% CI)

OR

(95% CI)

OR

(95% CI)

Rs12514417(ref: TT)

        

TG + GG

1.08

(0.92–1.27)

1.79

(1.18–2.72)

0.72

(0.39–1.33)

0.83

(0.23–3.08)

Sex (ref: Female)

        

Male

1

(0.84–1.19)

1.33

(0.62–2.85)

1.35

(0.73–2.48)

0.43

(0.11–1.69)

Age

1.07

(1.06–1.08)

1.04

(1.02–1.07)

1.01

(0.98–1.05)

0.96

(0.90–1.02)

Education (ref: Elementary School)

        

Junior & Senior High School

1.11

(0.87–1.41)

0.84

(0.40–1.76)

1.12

(0.38–3.33)

0.25

(0.04–1.41)

University & above

0.93

(0.72–1.20)

0.67

(0.31–1.45)

0.9

(0.29–2.77)

0.13

(0.02–0.96)

Smoking (ref: No)

        

Yes

0.97

(0.79–1.21)

0.71

(0.46–1.11)

1.2

(0.61–2.34)

0.94

(0.27–3.27)

Physical activity (ref: No)

        

Yes

1.08

(0.92–1.27)

0.83

(0.54–1.29)

0.69

(0.38–1.22)

1.9

(0.59–6.17)

BMI

1

(0.98–1.03)

0.97

(0.91–1.03)

0.99

(0.92–1.07)

0.93

(0.78–1.10)

Diabetes (ref: No)

        

Yes

1.48

(1.25–1.76)

1.48

(0.93–2.35)

1.28

(0.62–2.64)

2.88

(0.69–12.10)

Hypertension (ref: No)

        

Yes

2.25

(1.89–2.68)

3.03

(1.85–4.96)

1.32

(0.68–2.56)

1.61

(0.39–6.66)

Hyperlipidemia (ref: No)

        

Yes

1.63

(1.37–1.94)

1.63

(1.02–2.61)

1.55

(0.82–2.92)

0.87

(0.21–3.68)

  1. Abbreviations: OR = odds ratio, CI = 95% confidence interval, BMI = body mass index, TT, TG, and GG = rs12514417 genotypes