Skip to main content
Fig. 7 | Nutrition & Metabolism

Fig. 7

From: Preoperative administration of branched-chain amino acids reduces postoperative insulin resistance in rats by reducing liver gluconeogenesis

Fig. 7

Schematic diagram of the effect of BCAA on alleviating postoperative liver gluconeogenesis. BCAA inhibits dephosphorylation of CRTC2, thereby reducing CRTC2 binding to p-CREB, decreasing transcription and translation of G6PC, decreasing hepatic gluconeogenesis and reducing postoperative insulin resistance. BCAA: branched-chain amino acids, CREB: cAMP response element binding protein, CRTC2: CREB regulated transcriptional coactivator 2, G6PC: glucose-6phosphatase

Back to article page

Nutrition & Metabolism

ISSN: 1743-7075

Contact us