Fig. 6
From: Curcumin improves insulin sensitivity in high-fat diet-fed mice through gut microbiota
Gut microbiota mediate the effects of curcumin on regulating FGF15. A Real-time quantitative PCR analysis of Fgf15 expression in the ileum of HFD mice treated with curcumin or vehicle for 4 weeks (n = 8/group). B Western blotting (left panel) and densitometric analyses (right panel) of FGF15 in the ileum from mice in A. C Serum FGF15 levels of mice in A (n = 8/group). D Real-time quantitative PCR analysis of Fgf15 expression in the ileum of vehicle- and curcumin-treated HFD-fed mice after antibiotic treatment (n = 8/group). E Western blotting (left panel) and densitometric analyses (right panel) of FGF15 in the ileum from mice in D. F Serum FGF15 levels of mice in D (n = 8/group). G Real-time quantitative PCR analysis of Fgf15 expression in the ileum of endogenous gut microbiota-depleted mice colonized with the microbiota harvested from curcumin- and vehicle-treated HFD-fed mice during HFD feeding (n = 8/group). H Western blotting (left panel) and densitometric analyses (right panel) of FGF15 in the ileum from mice in G. I Serum FGF15 levels of mice in G (n = 8/group). Numerical data are shown as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001