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Fig. 7 | Nutrition & Metabolism

Fig. 7

From: Angiotensin(1–7) attenuates visceral adipose tissue expansion and lipogenesis by suppression of endoplasmic reticulum stress via Mas receptor

Fig. 7

Ang(1–7) treatment induced decreased lipogenesis and ER stress related markers in differentiated 3T3-L1 cells pre-loaded with palmitic acid. The differentiated cells were pre-loaded with 400 µM of palmitic acid for 24 h to induce ER stress, then treated with NS, 10–9 mmol/L Ang(1–7) or both Ang(1–7) and 10–6 mmol/L A779 for 24 h. A and B Representative Western blot and relative protein levels of lipogenesis related markers. C and D Representative Western blot and relative protein levels of ER stress related markers. Data are represented as mean ± SEM. *p < 0.05 versus NS group; #p < 0.05 versus Ang(1–7) group by one-way ANOVA. Ang(1–7), angiotensin(1–7); NS, normal saline; FAS, fatty acid synthase; ACCα, acetyl-CoA carboxylase α; M-SREBP-1c, mature sterol regulatory element-binding protein-1c; GRP78, glucose regulated protein 78; ATF4, activating transcription factor 4; CHOP, C/EBP homologous protein

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