Fig. 3
Effect of low calcium diet on intestinal microbiota and metabolic profiles. A LEfSe analysis of cladogram in group N and group C. B The correlation graph shows the correlation between intestinal microbiota with fecal metabolites. C The correlation graph shows the correlation between intestinal microbiota with plasma metabolites. D The volcano map of fecal metabolites between the N group and C group. E The volcano map of plasma metabolites between the N group and C group. F The KEGG bubble map of fecal metabonomics between the low calcium group and the control group. G The KEGG bubble map of plasma metabolites between the low calcium group and the control group. The larger the Abscissa in the picture, the higher the enrichment of differential metabolites in the pathway. The color of the point represents the P-value value of the hypergeometric test, and the smaller the value is, the greater the reliability of the test is and the more statistically significant it is. The size of the point represents the number of differential metabolites in the corresponding pathway, and the larger the point, the more differential metabolites in the pathway