Table 2 The univariate and multivariate analyses of OS
Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
Hazard Ratio | p value | Hazard Ratio | p value | |
Age (years) | 1.00 (0.98–1.03) | 0.75 | – | – |
Gender (Male/Female) | 1.32 (0.77–2.33) | 0.34 | – | – |
BMI (kg/m2) | 0.95 (0.87–1.03) | 0.23 | – | – |
Tumor location (Across/others) | 3.90 (1.76–8.64) | 0.001 | 1.49 (0.58–3.88) | 0.41 |
Lauren Type | ||||
 Intestinal | ref |  |  |  |
 Diffuse | 1.43 (0.79–2.60) | 0.24 | – | – |
 Mix | 1.51 (0.71–3.23) | 0.28 | – | – |
Tumor Differentiation | ||||
 High | ref |  |  |  |
 Moderate | - | 0.91 | – | – |
 Poor | - | 0.91 | – | – |
Postoperative chemotherapy | ||||
 Yes/No | 1.49 (0.85–2.63) | 0.17 | – | – |
pTNM stage (IV/ I-III) | 4.50 (2.37–8.57) |  < 0.001 | 2.70 (1.30–5.63) | 0.008 |
Perineural invasion (Positive/Negative) | 9.19 (3.32–25.44) |  < 0.001 | 6.01 (2.08–17.35) | 0.001 |
Lymphatic invasion (Positive/Negative) | 2.69 (1.52–4.76) | 0.001 | 1.10 (0.49–2.47) | 0.82 |
Venous invasion (Positive/Negative) | 2.32 (1.36–3.95) | 0.002 | 1.64 (0.78–3.45) | 0.20 |
HER2 (3 + /0–2 +) | 1.10 (0.34–3.50) | 0.88 | – | – |
Preoperative CEA (ug/L, > 5/ ≤ 5) | 2.88 (1.45–5.73) | 0.003 | 1.83 (0.83–4.02) | 0.13 |
Preoperative CA199 (U/ml, > 37/ ≤ 37) | 2.14 (1.17–3.91) | 0.01 | 1.45 (0.73–2.85) | 0.29 |
Group (High PLMI/Low PLMI) | 2.56 (1.33–4.95) | 0.005 | 2.13 (1.07–4.22) | 0.03 |