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Table 1 Specific information of 52 different metabolites and statistical data compared among groups

From: Untargeted metabolomic analysis of ischemic injury in human umbilical vein endothelial cells reveals the involvement of arginine metabolism

HMDB ID

Metabolites

Chemical Formula

OGD 3 h (campared to NC)

OGD 6 h (campared to NC)

OGD 9 h (campared to NC)

VIP

P value

VIP

P value

VIP

P value

HMDB0113077

PE-NMe(16:1(9Z)/22:2(13Z,16Z))

C44H82NO8P

1.70289

1.92592E−05

1.66745

2.28916E−07

2.30093

4.6024E−15

HMDB00269

C17 Sphinganine

C18H39NO2

1.46233

2.352E−04

1.33258

3.065E−04

1.21892

0.014

HMDB0000567

Cinnamic acid

C9H8O2

1.86402

1.52399E−07

1.73518

2.1238E−08

2.04107

6.44925E−08

HMDB0000190

L-( +)-Lactic acid

C3H6O3

2.11509

2.50911E−11

1.90061

1.22435E−11

1.88508

1.83479E−12

HMDB15573

Niflumic acid

C13H9F3N2O2

2.00148

7.47579E−11

1.83636

4.87347E−11

2.21157

3.30513E−11

HMDB0009610

PE(22:4(7Z,10Z,13Z,16Z)/P-18:0)

C45H82NO7P

1.04598

0.023

1.56711

9.03504E−06

1.27268

7.476E−04

HMDB0002117

Oleamide

C18H35NO

1.34176

0.001

1.41106

1.044E−04

1.48937

9.962E−04

HMDB0000267

L-Pyroglutamic acid

C5H7NO3

2.04281

3.49203E−12

1.85208

1.460E−11

2.22692

1.42635E−11

HMDB0112334

PS(15:0/22:0)

C43H84NO10P

1.10491

0.018

1.5416

1.64053E−05

1.41924

8.97162E−05

HMDB0002823

Docosatrienoic acid

C22H38O2

2.04249

2.65503E−12

1.74053

1.537E−08

1.58928

3.396E−04

HMDB00269

sphinganine

C18H39NO2

2.030

3.50456E−12

1.87921

8.040E−13

1.43512

0.002

HMDB0059611

3-Thiomorpholinecarboxylic acid

C5H9NO2S

1.98806

3.120E−10

1.77605

2.80179E−09

2.16666

4.06858E−10

HMDB0000158

L-Tyrosine

C9H11NO3

1.6261

2.06472E−05

1.7731

2.57191E−09

2.13575

1.94702E−09

HMDB0004080

Anandamide (20:2, n-6)

C22H37NO2

2.0825

2.07568E−14

1.900

5.860E−14

1.7336

5.00426E−05

HMDB0010569

PE-NMe(16:0/18:1(9Z))[U]

C40H78NO8P

1.20726

0.005

1.07189

0.008

2.23574

5.44715E−12

HMDB0000210

Pantothenic acid

C9H17NO5

1.99642

1.1488E−10

1.85432

1.0905E−11

2.25273

3.8706E−12

HMDB0257271

3-Deoxyvitamin D3

C27H38O3

1.75864

1.22095E−06

1.5958

1.958E−06

1.20133

0.013

HMDB0008090

PC(18:1(11Z)/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

C48H82NO8P

1.51545

3.410E−04

1.86638

1.550E−10

1.87125

6.82929E−12

HMDB14747

2-Ethylisonicotinic acid

C8H10N2S

1.50266

1.659E−04

1.36405

1.837E−04

1.72477

6.447E−05

HMDB0000157

Hypoxanthine

C5H4N4O

1.47417

2.384E−04

1.47948

2.51303E−05

1.15849

0.018

HMDB0304793

4-Oxoproline

C5H6NO3

2.11805

1.96164E−11

1.86463

1.75681E−10

1.83714

1.08157E−10

HMDB0259164

Tributyl phosphate

C12H27O4P

1.71615

2.520E−06

1.72378

2.56868E−08

1.73184

6.6567E−05

HMDB0015488

Antrafenine

C30H26F6N4O2

1.26498

0.005

1.44279

9.860E−05

1.10069

0.005

HMDB0000734

trans-3-Indoleacrylic acid

C11H9NO2

1.99701

4.86916E−10

1.85511

1.47929E−11

2.210

3.000E−11

HMDB0028910

Isoleucine

C12H24N2O3

1.2761

3.382E−03

1.59195

2.35788E−06

1.67513

1.282E−04

HMDB0001138

N-Acetyl-L-glutamic acid

C7H11NO5

1.79597

3.7027E−06

1.27394

0.001

1.8452

9.45557E−06

HMDB0029586

1-Octadecanamine

C18H39N

1.710

2.80175E−06

1.72933

2.15626E−08

1.29633

0.006

HMDB0000191

L-Aspartic acid

C4H7NO4

2.15264

1.549E−12

1.92564

1.36645E−12

1.64639

6.14935E−07

HMDB0011493

LysoPE(0:0/22:4(7Z,10Z,13Z,16Z))

C27H48NO7P

1.78406

4.391E−07

1.900

8.5147E−14

2.140

1.53227E−09

HMDB0009243

PE(O-20:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

C47H82NO8P

1.920

1.76082E−07

1.71293

1.90797E−07

1.58694

2.91321E−06

HMDB0004866

Lactosylceramide (d18:1/12:0)

C42H79NO13

1.57092

1.715E−04

1.57817

7.55103E−06

1.69056

1.398E−07

/

Docosylphosphonic acid

/

1.56857

4.535E−05

1.60114

1.5028E−06

1.93659

1.50443E−06

HMDB0000064

Creatine

C4H9N3O2

1.40158

5.148E−04

1.76162

5.00067E−09

2.240

8.62628E−12

HMDB0253127

(2E)-hexadecenoylcarnitine

C23H43NO4

1.66186

8.090E−06

1.57845

2.720E−06

1.02879

0.035

HMDB0251511

Arginine

C6H14N4O2

1.53586

3.530E−04

1.68193

1.62749E−07

1.740

4.43055E−05

HMDB0010662

PG(18:3(6Z,9Z,12Z)/0:0)

C42H77O10P

1.400

7.086E−04

1.42783

6.591E−05

1.25316

8.898E−03

HMDB0011496

LysoPE(0:0/22:6(4Z,7Z,10Z,13Z,16Z,19Z))

C27H44NO7P

1.7615

1.06164E−06

1.86598

4.13293E−12

1.89127

2.91103E−06

HMDB0303320

6-Oxohexanoic acid

C6H11NO3

1.430

0.001

1.740

1.02059E−07

1.74617

1.61092E−08

HMDB0304946

Indole-3-acetic acid

C12H13NO2

2.0012

9.2389E−11

1.82885

9.10133E−11

2.19543

9.14134E−11

HMDB0112341

PS(15:0/24:1(15Z))

C45H86NO10P

1.26641

6.263E−03

1.48342

5.397E−05

1.49756

2.162E−05

HMDB0008949

PE(16:0/17:0)[U]

C37H74NO7P

1.94426

2.57888E−08

1.57179

3.26879E−06

2.16404

4.68133E−10

HMDB0000191

L-( +)-Aspartic acid

C4H7NO4

2.03892

1.34506E−11

1.805

4.24244E−10

1.7339

8.90807E−05

HMDB0000156

Malic acid

C4H6O5

2.0371

2.77918E−09

1.78053

1.85329E−08

1.86592

1.38296E−11

/

PC(O-16:1(11Z)/2:0)

/

2.10827

9.564E−17

1.68483

1.371E−07

1.25484

0.008

HMDB0115667

PA(22:0/a-25:0)

C50H99O8P

1.87776

5.210E−07

1.79838

6.83898E−09

1.72528

3.85648E−08

HMDB0000097

Choline

C5H14NO

1.25932

0.004

1.40849

9.15523E−05

1.22327

0.016

HMDB0000641

L-Glutamine

C5H10N2O3

1.89853

1.30733E−08

1.760

5.97735E−09

2.120

3.5229E−09

HMDB0059795

Gluten exorphin B5

C30H38N6O11

1.01634

0.028

1.03318

0.012

1.17445

0.002

HMDB0011487

LysoPE(0:0/20:4(5Z,8Z,11Z,14Z))

C25H44NO7P

1.780

4.515E−07

1.86795

5.18856E−12

1.95136

7.51815E−07

HMDB0011494

LysoPE(0:0/22:5(4Z,7Z,10Z,13Z,16Z))

C27H46NO7P

1.56903

4.46706E−05

1.73288

1.7063E−08

1.52629

6.760E−04

HMDB0250301

Citiolone

C6H9NO2S

1.96733

6.38225E−10

1.79882

6.35378E−10

2.16223

6.37351E−10

HMDB0000159

L-Phenylalanine

C9H11NO2

1.86684

1.38922E−07

1.73517

2.121E−08

2.04383

5.90069E−08

  1. OGD, Oxygen–glucose deprivation; VIP, Variable important in projection; NC, normal control group
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Nutrition & Metabolism

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