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  1. The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.

    Authors: Mireia Olivan, Jochen Springer, Sílvia Busquets, Anika Tschirner, Maite Figueras, Miriam Toledo, Cibely Fontes-Oliveira, Maria Inés Genovese, Paula Ventura da Silva, Angelica Sette, Francisco J López-Soriano, Stefan Anker and Josep M Argilés
    Citation: Nutrition & Metabolism 2012 9:76
  2. Prostate cancer (PCa) is dependent on androgen receptor signaling and aberrations of the PI3K-Akt-mTORC1 pathway mediating excessive and sustained growth signaling. The nutrient-sensitive kinase mTORC1 is upre...

    Authors: Bodo C Melnik, Swen Malte John, Pedro Carrera-Bastos and Loren Cordain
    Citation: Nutrition & Metabolism 2012 9:74
  3. Visceral fat accumulation is one of the most important predictors of mortality in obese populations. Administration of green tea extract (GTE) can reduce body fat and reduce the risk of obesity-related disease...

    Authors: Takahiro Hasumura, Yasuhito Shimada, Junya Kuroyanagi, Yuhei Nishimura, Shinichi Meguro, Yoshinori Takema and Toshio Tanaka
    Citation: Nutrition & Metabolism 2012 9:73
  4. Sphingolipids are ubiquitous and critical components of biological membranes. Their biosynthesis starts with soluble precursors in the endoplasmic reticulum and culminates in the Golgi complex and plasma membr...

    Authors: M Mahmood Hussain, Weijun Jin and Xian-Cheng Jiang
    Citation: Nutrition & Metabolism 2012 9:71
  5. There is growing evidence that dietary antioxidants could have favorable effects on the attenuation and prevention of metabolic disorders. In the current study we investigated the association of dietary total ...

    Authors: Zahra Bahadoran, Mahdieh Golzarand, Parvin Mirmiran, Niloofar Shiva and Fereidoun Azizi
    Citation: Nutrition & Metabolism 2012 9:70
  6. High fat feeding in rodents generally leads to obesity and insulin resistance whereas in humans this is only seen if dietary carbohydrate is also high, the result of the anabolic effect of poor regulation of g...

    Authors: Saihan Borghjid and Richard David Feinman
    Citation: Nutrition & Metabolism 2012 9:69
  7. Prospective studies in humans examining the effects of fructose consumption on biological markers associated with the development of metabolic syndrome are lacking. Therefore we investigated the relative effec...

    Authors: Chad L Cox, Kimber L Stanhope, Jean Marc Schwarz, James L Graham, Bonnie Hatcher, Steven C Griffen, Andrew A Bremer, Lars Berglund, John P McGahan, Nancy L Keim and Peter J Havel
    Citation: Nutrition & Metabolism 2012 9:68
  8. Leucine (Leu) regulates muscle protein synthesis (MPS) producing dose-dependent plasma Leu and MPS responses from free amino acid solutions. This study examined the role of Leu content from dietary proteins in...

    Authors: Layne E Norton, Gabriel J Wilson, Donald K Layman, Christopher J Moulton and Peter J Garlick
    Citation: Nutrition & Metabolism 2012 9:67
  9. Genome-wide association studies (GWAS) have recently identified several new genetic variants associated with obesity. The majority of the variants are within introns or between genes, suggesting they affect ge...

    Authors: Piriya Yoganathan, Subashini Karunakaran, Maggie M Ho and Susanne M Clee
    Citation: Nutrition & Metabolism 2012 9:65
  10. Obesity associates with low-grade inflammation and adipose tissue remodeling. Using sensitive high-throughput protein arrays we here investigated adipose tissue cytokine and angiogenesis-related protein profil...

    Authors: Eveliina Kurki, Jin Shi, Essi Martonen, Piet Finckenberg and Eero Mervaala
    Citation: Nutrition & Metabolism 2012 9:64
  11. Paraoxonase 1 (PON1) is a HDL-associated esterase/lactonase and its activity is inversely related to the risk of cardiovascular diseases. The aim of the present study was to evaluate the effect of a high-salt ...

    Authors: Waleska Cláudia Dornas, Wanderson Geraldo de Lima, Rinaldo Cardoso dos Santos, Melina Oliveira de Souza, Maísa Silva, Mirla Fiuza Diniz and Marcelo Eustáquio Silva
    Citation: Nutrition & Metabolism 2012 9:63
  12. Small-for-gestational age (SGA) at birth increases risk of development of adult obesity and insulin resistance. A model of SGA rat offspring has been shown to exhibit increased adipose tissue expression of a k...

    Authors: Jennifer K Yee, Wai-Nang Paul Lee, Michael G Ross, Robert H Lane, Guang Han, Juan Vega and Mina Desai
    Citation: Nutrition & Metabolism 2012 9:62
  13. The prevalence of obesity among Mexican women is high and it could be related to micronutrient status. We evaluated in a cross-sectional study the associations of zinc and vitamins A, C and E concentrations wi...

    Authors: Olga Patricia García, Dolores Ronquillo, María del Carmen Caamaño, Mariela Camacho, Kurt Zane Long and Jorge L Rosado
    Citation: Nutrition & Metabolism 2012 9:59
  14. Recent evidence suggests that the effects of certain food additives may be synergistic or additive. Aspartame (ASP) and Monosodium Glutamate (MSG) are ubiquitous food additives with a common moiety: both conta...

    Authors: Kate S Collison, Nadine J Makhoul, Marya Z Zaidi, Rana Al-Rabiah, Angela Inglis, Bernard L Andres, Rosario Ubungen, Mohammed Shoukri and Futwan A Al-Mohanna
    Citation: Nutrition & Metabolism 2012 9:58
  15. Increased amino acid availability stimulates muscle protein synthesis, however, aged muscle appears less responsive to the anabolic effects of amino acids when compared to the young. We aimed to compare change...

    Authors: Yifan Yang, Tyler A Churchward-Venne, Nicholas A Burd, Leigh Breen, Mark A Tarnopolsky and Stuart M Phillips
    Citation: Nutrition & Metabolism 2012 9:57
  16. Although the measurement site at L4–L5 for visceral adipose tissue (VAT) has been commonly accepted, some researchers suggest that additional upper sites (i.e., L1–L2 and L2–L3) are useful for estimating VAT v...

    Authors: Rina So, Tomoaki Matsuo, Hiroyuki Sasai, Miki Eto, Takehiko Tsujimoto, Kousaku Saotome and Kiyoji Tanaka
    Citation: Nutrition & Metabolism 2012 9:56
  17. Limited data on sex differences in body composition changes in response to higher protein diets (PRO) compared to higher carbohydrate diets (CARB) suggest that a PRO diet helps preserve lean mass (LM) in women...

    Authors: Ellen M Evans, Mina C Mojtahedi, Matthew P Thorpe, Rudy J Valentine, Penny M Kris-Etherton and Donald K Layman
    Citation: Nutrition & Metabolism 2012 9:55
  18. Dietary supplements containing L-arginine have been marketed with the purpose of increasing vasodilatation, and thus, blood and oxygen supply to the exercising muscle. The present study evaluated the acute eff...

    Authors: Thiago Silveira Alvares, Carlos Adam Conte-Junior, Joab Trajano Silva and Vânia Margaret Flosi Paschoalin
    Citation: Nutrition & Metabolism 2012 9:54
  19. The expression of PDK4 is elevated by diabetes, fasting and other conditions associated with the switch from the utilization of glucose to fatty acids as an energy source. It is previously shown that peroxisom...

    Authors: Rita Rinnankoski-Tuikka, Mika Silvennoinen, Sira Torvinen, Juha J Hulmi, Maarit Lehti, Riikka Kivelä, Hilkka Reunanen and Heikki Kainulainen
    Citation: Nutrition & Metabolism 2012 9:53
  20. The present study investigated plasma levels of gut-brain axis peptides ghrelin, obestatin, NPY and PYY after consumption of a high-carbohydrate (HC) and high-protein (HP) breakfast in patients with anorexia n...

    Authors: Dana Sedlackova, Jana Kopeckova, Hana Papezova, Vojtech Hainer, Hana Kvasnickova, Martin Hill and Jara Nedvidkova
    Citation: Nutrition & Metabolism 2012 9:52
  21. Diets rich in omega-3 fatty acids and low in saturated fat were found beneficially associated with blood lipids and cardio-vascular health. Lean reindeer meet and local cold water white-fish species high in om...

    Authors: Natalia Petrenya, Magritt Brustad, Marie Cooper, Liliya Dobrodeeva, Fatima Bichkaeva, Gulnara Lutfalieva and Jon Øyvind Odland
    Citation: Nutrition & Metabolism 2012 9:51
  22. Epidemiology and animal models suggest that dietary monosodium glutamate (MSG) may contribute to the onset of obesity and the metabolic syndrome.

    Authors: Tonkla Insawang, Carlo Selmi, Ubon Cha’on, Supattra Pethlert, Puangrat Yongvanit, Premjai Areejitranusorn, Patcharee Boonsiri, Tueanjit Khampitak, Roongpet Tangrassameeprasert, Chadamas Pinitsoontorn, Vitoon Prasongwattana, M Eric Gershwin and Bruce D Hammock
    Citation: Nutrition & Metabolism 2012 9:50
  23. Folate, vitamin B-12, and vitamin B-6 are essential nutritional components in one-carbon metabolism and are required for methylation capacity. The availability of these vitamins may therefore modify methylatio...

    Authors: Nick van Wijk, Carol J Watkins, Robert J J Hageman, John C W Sijben, Patrick G H J Kamphuis, Richard J Wurtman and Laus M Broersen
    Citation: Nutrition & Metabolism 2012 9:49
  24. Whey protein increases postprandial serum insulin levels. This has been associated with increased serum levels of leucine, isoleucine, valine, lysine, threonine and the incretin hormone glucose-dependent insul...

    Authors: Albert Salehi, Ulrika Gunnerud, Sarheed J Muhammed, Elin Östman, Jens J Holst, Inger Björck and Patrik Rorsman
    Citation: Nutrition & Metabolism 2012 9:48
  25. Dehydroepiandrosterone (DHEA) is precursor of sex steroid hormone. We demonstrated that acute DHEA injection to type 1 diabetes model rats induced improvement of hyperglycemia. However, the effect of the combi...

    Authors: Koji Sato, Motoyuki Iemitsu, Katsuji Aizawa, Noboru Mesaki, Ryuichi Ajisaka and Satoshi Fujita
    Citation: Nutrition & Metabolism 2012 9:47
  26. The beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs), especially in dyslipidemic subjects with a high risk of cardiovascular disease, are widely described in the literature. A lot of effec...

    Authors: Simone Schmidt, Frank Stahl, Kai-Oliver Mutz, Thomas Scheper, Andreas Hahn and Jan Philipp Schuchardt
    Citation: Nutrition & Metabolism 2012 9:45
  27. The relationship between TSH and the lipid profile is contradictory because few studies have excluded the potential influence of the thyroid hormones (TH). The aim of the present study was to evaluate the rela...

    Authors: Chao Xu, Xiaomei Yang, Wenhui Liu, Haitao Yuan, Chunxiao Yu, Ling Gao and Jiajun Zhao
    Citation: Nutrition & Metabolism 2012 9:44
  28. Emerging evidence indicates that there is an association between vitamin D and obesity. The aim of this study was to investigate whether the level of serum 25-hydroxyvitamin D3 [25(OH)D3] in the elderly is influe...

    Authors: Alexandra Jungert, Heinz J Roth and Monika Neuhäuser-Berthold
    Citation: Nutrition & Metabolism 2012 9:42
  29. DNA methylation is an epigenetic phenomenon that can modulate gene function by up or downregulation of gene expression. Vitamin B12 and folate pathways are involved in the production of S-Adenosylmethionine, the ...

    Authors: Sílvia Fernàndez-Roig, Shao-Chiang Lai, Michelle M Murphy, Joan Fernandez-Ballart and Edward V Quadros
    Citation: Nutrition & Metabolism 2012 9:41
  30. Provision of dietary amino acids increases skeletal muscle protein synthesis (MPS), an effect that is enhanced by prior resistance exercise. As a fundamentally necessary process in the enhancement of muscle ma...

    Authors: Tyler A Churchward-Venne, Nicholas A Burd and Stuart M Phillips
    Citation: Nutrition & Metabolism 2012 9:40
  31. Nutritional manipulations during fetal growth may induce long-term metabolic effects in postnatal life. The aim of the study was to test whether combined treatment of pregnant sows with alpha-ketoglutarate and β-...

    Authors: Marcin R Tatara, Witold Krupski, Barbara Tymczyna and Tadeusz Studziński
    Citation: Nutrition & Metabolism 2012 9:39
  32. We have reported a reduction in fatty acid oxidation (FAO) at the whole-body level and in skeletal muscle in severely obese (BMI ≥ 40 kg/m2) individuals; this defect is retained in cell culture suggesting an inhe...

    Authors: Audrey D Eaves, Ashley Colon, Katrina D DuBose, David Collier and Joseph A Houmard
    Citation: Nutrition & Metabolism 2012 9:38
  33. Although soybeans have the ability to attenuate insulin resistance, it is insufficient to alleviate type 2 diabetic symptoms and different types of fermented soybeans may have even better anti-diabetic effects...

    Authors: Hye Jeong Yang, Dae Young Kwon, Min Jung Kim, Suna Kang and Sunmin Park
    Citation: Nutrition & Metabolism 2012 9:37
  34. Glutathione has a wide range of functions; it is an endogenous anti-oxidant and plays a key role in the maintenance of intracellular redox balance and detoxification of xenobiotics. Several studies have indica...

    Authors: Penelope AE Main, Manya T Angley, Catherine E O'Doherty, Philip Thomas and Michael Fenech
    Citation: Nutrition & Metabolism 2012 9:35
  35. N-3 polyunsaturated fatty acids, such as docosahexaenoic acid (DHA; 22:6n-3), has clinical significance in the prevention and reversal of nonalcoholic steatohepatitis (NASH). However, the precious mechanism un...

    Authors: Xiaoqin Luo, Yan Yang, Tianran Shen, Xilan Tang, Yunjun Xiao, Tangbin Zou, Min Xia and Wenhua Ling
    Citation: Nutrition & Metabolism 2012 9:34
  36. Dietary fibre is both preventive and therapeutic for bowel functional diseases. Soluble cocoa products are good sources of dietary fibre that may be supplemented with this dietary component. This study assesse...

    Authors: Beatriz Sarriá, Sara Martínez-López, Aránzazu Fernández-Espinosa, Miren Gómez-Juaristi, Luis Goya, Raquel Mateos and Laura Bravo
    Citation: Nutrition & Metabolism 2012 9:33
  37. Serhan and colleagues introduced the term "Resoleomics" in 1996 as the process of inflammation resolution. The major discovery of Serhan's work is that onset to conclusion of an inflammation is a controlled pr...

    Authors: Margarethe M Bosma-den Boer, Marie-Louise van Wetten and Leo Pruimboom
    Citation: Nutrition & Metabolism 2012 9:32
  38. The aim of the study was to verify that the concomitant presence of grapefruit flavonoid extract with inulin in a Western-type diet may provide synergistic effects to the hindgut metabolism, as well as blood l...

    Authors: Adam Jurgoński, Jerzy Juśkiewicz, Karolina Kowalska and Zenon Zduńczyk
    Citation: Nutrition & Metabolism 2012 9:31
  39. Diabetic nephropathy is one of major complications of diabetes mellitus. Although chromium is an essential element for carbohydrate and lipid metabolism, its effects on diabetic nephropathy are not well unders...

    Authors: Mustafa Yavuz Selcuk, Bilge Aygen, Ayhan Dogukan, Zeynep Tuzcu, Fatih Akdemir, James R Komorowski, Mustafa Atalay and Kazim Sahin
    Citation: Nutrition & Metabolism 2012 9:30
  40. Different foods can modulate cardiometabolic risk factors in persons already affected by metabolic alterations. The objective of this study was to assess, in healthy overweight individuals, the impact of a die...

    Authors: Juscelino Tovar, Anne Nilsson, Maria Johansson, Rickard Ekesbo, Ann-Margreth Åberg, Ulla Johansson and Inger Björck
    Citation: Nutrition & Metabolism 2012 9:29
  41. The purpose of this study was to determine the effects of the pre-workout supplement Assaultâ„¢ (MusclePharm, Denver, CO, USA) on upper and lower body muscular endurance, aerobic and anaerobic capacity, and choi...

    Authors: Brandon D Spradley, Kristy R Crowley, Chih-Yin Tai, Kristina L Kendall, David H Fukuda, Enrico N Esposito, Sarah E Moon and Jordan R Moon
    Citation: Nutrition & Metabolism 2012 9:28
  42. Two major risk factors for the onset of fatty liver disease are excessive alcohol intake and obesity, the latter being associated with non-alcoholic fatty liver disease (NAFLD). The aim of this study was to ex...

    Authors: Hwan-Hee Jang, Mi-Young Park, Heon-Woong Kim, Young-Min Lee, Kyung-A Hwang, Jae-Hak Park, Dong-Sik Park and Oran Kwon
    Citation: Nutrition & Metabolism 2012 9:27

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