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  1. Metabolic Syndrome (MetS) represents a constellation of markers that indicates a predisposition to diabetes, cardiovascular disease and other pathologic states. The definition and treatment are a matter of cur...

    Authors: Jeff S Volek and Richard D Feinman

    Citation: Nutrition & Metabolism 2005 2:31

    Content type: Review

    Published on:

  2. Alzheimer's disease (AD) is a progressive neurodegenerative disorder that primarily strikes the elderly. Studies in both humans and animal models have linked the consumption of cholesterol and saturated fats w...

    Authors: Ingrid Van der Auwera, Stefaan Wera, Fred Van Leuven and Samuel T Henderson

    Citation: Nutrition & Metabolism 2005 2:28

    Content type: Research

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  3. We have previously reported that rheumatoid arthritis patients, who adopted a modified Cretan Mediterranean diet, obtained a reduction in disease activity and an improvement in physical function and vitality. ...

    Authors: Linda Hagfors, Ingela Nilsson, Lars Sköldstam and Gunnar Johansson

    Citation: Nutrition & Metabolism 2005 2:26

    Content type: Research

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  4. Recent trends in weight loss diets have led to a substantial increase in protein intake by individuals. As a result, the safety of habitually consuming dietary protein in excess of recommended intakes has been...

    Authors: William F Martin, Lawrence E Armstrong and Nancy R Rodriguez

    Citation: Nutrition & Metabolism 2005 2:25

    Content type: Review

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  5. Epidemiological studies have linked low dietary magnesium (Mg) to low bone mineral density and osteoporosis. Mg deficiency in animal models has demonstrated a reduction in bone mass and increase in skeletal fr...

    Authors: Robert K Rude, Helen E Gruber, Livia Y Wei and Angelica Frausto

    Citation: Nutrition & Metabolism 2005 2:24

    Content type: Research

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  6. Studies on the effects of (-)-hydroxycitric acid (HCA) in humans are controversial. As differences in the HCA preparations may contribute to this apparent discrepancy, the aim of the current study is to compar...

    Authors: Johanna Louter-van de Haar, Peter Y Wielinga, Anton JW Scheurink and Arie G Nieuwenhuizen

    Citation: Nutrition & Metabolism 2005 2:23

    Content type: Research

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  7. Melatonin, originally discovered as a hormone of the pineal gland, is also produced in other organs and represents, additionally, a normal food constituent found in yeast and plant material, which can influenc...

    Authors: Rüdiger Hardeland and SR Pandi-Perumal

    Citation: Nutrition & Metabolism 2005 2:22

    Content type: Review

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  8. Unloading of skeletal muscle causes atrophy and loss of contractile function. In part, this response is believed to be mediated by the transcription factor nuclear factor-kappa B (NF-κB). Both curcumin, a comp...

    Authors: Mehran Farid, Michael B Reid, Yi-Ping Li, Eric Gerken and William J Durham

    Citation: Nutrition & Metabolism 2005 2:20

    Content type: Research

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  9. The Family Blood Pressure Program is an ongoing, NHLBI-sponsored, multi-center program to study the genetic determinants of high blood pressure. The goal of this particular study was to study patterns of metab...

    Authors: Aldi T Kraja, DC Rao, Alan B Weder, Thomas H Mosley, Stephen T Turner, Chao Agnes Hsiung, Thomas Quertermous, Richard Cooper, J David Curb and Michael A Province

    Citation: Nutrition & Metabolism 2005 2:17

    Content type: Research

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  10. A low fat, high carbohydrate diet in combination with regular exercise is the traditional recommendation for treating diabetes. Compliance with these lifestyle modifications is less than satisfactory, however,...

    Authors: Surender K Arora and Samy I McFarlane

    Citation: Nutrition & Metabolism 2005 2:16

    Content type: Review

    Published on:

  11. Obesity is associated with insulin resistance that can often be improved by caloric restriction and weight reduction. Although many physiological changes accompanying insulin resistance and its treatment have ...

    Authors: R Michael Raab, John Bullen, Joanne Kelleher, Christos Mantzoros and Gregory Stephanopoulos

    Citation: Nutrition & Metabolism 2005 2:15

    Content type: Research

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  12. Plasma total homocysteine (tHcy) is commonly elevated in persons with diabetes. This may be due to effects of insulin and/or glucose and/or metabolic control on the metabolism or plasma levels of tHcy. This st...

    Authors: Glen E Duncan, Sierra M Li and Xiao-Hua Zhou

    Citation: Nutrition & Metabolism 2005 2:13

    Content type: Research

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  13. Energy and Zinc (Zn) deficiencies have been associated with nutritional related growth retardation as well as growth hormone (GH) resistance. In this study, the relationship between suboptimal energy and/or Zn...

    Authors: Russell Rising, Julio F Scaglia, Conrad Cole, Rozalia Tverskaya, Debora Duro and Fima Lifshitz

    Citation: Nutrition & Metabolism 2005 2:10

    Content type: Research

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  14. Osteoporosis is a major public health problem with low bone mass affecting nearly half the women aged 50 years or older. Evidence from various studies has shown that higher body mass index (BMI) is a protectiv...

    Authors: Jonathan P Castro, Linda A Joseph, John J Shin, Surender K Arora, John Nicasio, Joshua Shatzkes, Irina Raklyar, Irina Erlikh, Vincent Pantone, Gul Bahtiyar, Leon Chandler, Lina Pabon, Sara Choudhry, Nilofar Ghadiri, Pramodini Gosukonda, Rangnath Muniyappa…

    Citation: Nutrition & Metabolism 2005 2:9

    Content type: Research

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  15. Cholesterol ester transfer protein (CETP) plays a major role in regulating the levels of LDL- and HDL-cholesterol. We previously observed a fish-oil-induced elevation of low-density lipoprotein (LDL)-and very-...

    Authors: Pujitha P de Silva, Alka Agarwal-Mawal, Phillip J Davis and Sukhinder Kaur Cheema

    Citation: Nutrition & Metabolism 2005 2:8

    Content type: Research

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  16. Although feeding deficits have been reported in snakes and lizards following vomeronasal system disruption, no deficit has been previously reported in a mammal. We tested gray short-tailed opossums with items ...

    Authors: Mimi Halpern, Yasmine Daniels and Ido Zuri

    Citation: Nutrition & Metabolism 2005 2:6

    Content type: Brief communication

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  17. Obesity and type 2 diabetes are occurring at epidemic rates in the United States and many parts of the world. The "obesity epidemic" appears to have emerged largely from changes in our diet and reduced physica...

    Authors: Heather Basciano, Lisa Federico and Khosrow Adeli

    Citation: Nutrition & Metabolism 2005 2:5

    Content type: Review

    Published on:

  18. Ancel Keys, Ph.D., who died in November, 2004, at the age of 100, was among the first scientists to recognize that human atherosclerosis is not an inevitable consequence of aging, and that a high-fat diet can ...

    Authors: Theodore B VanItallie

    Citation: Nutrition & Metabolism 2005 2:4

    Content type: Commentary

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  19. In 2001 the National Cholesterol Education Program (NCEP) provided a categorical definition for metabolic syndrome (c-MetS). We studied the extent to which two ethnic groups, Blacks and Whites were affected by...

    Authors: Aldi T Kraja, Steven C Hunt, James S Pankow, Richard H Myers, Gerardo Heiss, Cora E Lewis, DC Rao and Michael A Province

    Citation: Nutrition & Metabolism 2005 2:2

    Content type: Research

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  20. Phytoestrogens derived from soy foods (or isoflavones) have received prevalent usage due to their 'health benefits' of decreasing: a) age-related diseases, b) hormone-dependent cancers and c) postmenopausal sy...

    Authors: Edwin D Lephart, James P Porter, Trent D Lund, Lihong Bu, Kenneth DR Setchell, Gina Ramoz and William R Crowley

    Citation: Nutrition & Metabolism 2004 1:16

    Content type: Research

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  21. It is commonly held that "a calorie is a calorie", i.e. that diets of equal caloric content will result in identical weight change independent of macronutrient composition, and appeal is frequently made to the...

    Authors: Eugene J Fine and Richard D Feinman

    Citation: Nutrition & Metabolism 2004 1:15

    Content type: Review

    Published on:

  22. To compare the effects of isocaloric, energy-restricted very low-carbohydrate ketogenic (VLCK) and low-fat (LF) diets on weight loss, body composition, trunk fat mass, and resting energy expenditure (REE) in o...

    Authors: JS Volek, MJ Sharman, AL Gómez, DA Judelson, MR Rubin, G Watson, B Sokmen, R Silvestre, DN French and WJ Kraemer

    Citation: Nutrition & Metabolism 2004 1:13

    Content type: Research

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  23. There are likely many scenarios and pathways that can lead to metabolic syndrome. This paper reviews mechanisms by which the accumulation of visceral adipose tissue (VAT) may contribute to the metabolic syndro...

    Authors: Eric S Freedland

    Citation: Nutrition & Metabolism 2004 1:12

    Content type: Review

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  24. The high fat, low carbohydrate ketogenic diet (KD) was developed as an alternative to fasting for seizure management. While the mechanisms by which fasting and the KD inhibit seizures remain speculative, alter...

    Authors: John G Mantis, Nicole A Centeno, Mariana T Todorova, Richard McGowan and Thomas N Seyfried

    Citation: Nutrition & Metabolism 2004 1:11

    Content type: Research

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  25. The topical role of uric acid and its relation to cardiovascular disease, renal disease, and hypertension is rapidly evolving. Its important role both historically and currently in the clinical clustering phen...

    Authors: Melvin R Hayden and Suresh C Tyagi

    Citation: Nutrition & Metabolism 2004 1:10

    Content type: Review

    Published on:

  26. Epidemiological studies suggest a non-monotonic effect of alcohol consumption on cardiovascular risk, while there is strong evidence concerning the involvement of homocysteine levels on thrombosis. The aim of ...

    Authors: Christos Pitsavos, Demosthenes B Panagiotakos, Meropi D Kontogianni, Christina Chrysohoou, Yannis Chloptsios, Antonis Zampelas, Antonia Trichopoulou and Christodoulos Stefanadis

    Citation: Nutrition & Metabolism 2004 1:9

    Content type: Brief communication

    Published on:

  27. Although the effects of resistant starch (RS) on postprandial glycemia and insulinemia have been extensively studied, little is known about the impact of RS on fat metabolism. This study examines the relations...

    Authors: Janine A Higgins, Dana R Higbee, William T Donahoo, Ian L Brown, Melanie L Bell and Daniel H Bessesen

    Citation: Nutrition & Metabolism 2004 1:8

    Content type: Research

    Published on:

  28. Following a low carbohydrate diet, there is a shift towards more fat and less carbohydrate oxidation to provide energy to skeletal muscle, both at rest and during exercise. This review summarizes recent work o...

    Authors: Sandra J Peters and Paul J LeBlanc

    Citation: Nutrition & Metabolism 2004 1:7

    Content type: Review

    Published on:

  29. Daily energy expenditure consists of three components: basal metabolic rate, diet-induced thermogenesis and the energy cost of physical activity. Here, data on diet-induced thermogenesis are reviewed in relati...

    Authors: Klaas R Westerterp

    Citation: Nutrition & Metabolism 2004 1:5

    Content type: Review

    Published on:

  30. Insulin resistance induced by a high fat diet has been associated with alterations in lipid content and composition in skeletal muscle and adipose tissue. Administration of β3-adrenoceptor (β3-AR) agonists was...

    Authors: Christian Darimont, Marco Turini, Micheline Epitaux, Irène Zbinden, Myriam Richelle, Eulàlia Montell, Andreu Ferrer-Martinez and Katherine Macé

    Citation: Nutrition & Metabolism 2004 1:4

    Content type: Research

    Published on:

  31. The role of amino acids as substrates for protein synthesis is well documented. However, a function for amino acids in modulating the signal transduction pathways that regulate mRNA translation has only recent...

    Authors: Scot R Kimball and Leonard S Jefferson

    Citation: Nutrition & Metabolism 2004 1:3

    Content type: Review

    Published on:

  32. Impaired physical performance is a common but not obligate result of a low carbohydrate diet. Lessons from traditional Inuit culture indicate that time for adaptation, optimized sodium and potassium nutriture,...

    Authors: Stephen D Phinney

    Citation: Nutrition & Metabolism 2004 1:2

    Content type: Review

    Published on:

  33. A new Open Access journal, Nutrition & Metabolism (N&M) will publish articles that integrate nutrition with biochemistry and molecular biology. The open access process is chosen to provide rapid and accessible di...

    Authors: Richard D Feinman and M Mahmood Hussain

    Citation: Nutrition & Metabolism 2004 1:1

    Content type: Editorial

    Published on:

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