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  1. Content type: Research

    A number of different pathways to obesity with different metabolic outcomes are recognised. Prenatal undernutrition in rats leads to increased fat deposition in adulthood. However, the form of obesity is metab...

    Authors: Nichola Thompson, Korinna Huber, Mirijam Bedürftig, Kathrin Hansen, Jennifer Miles-Chan and Bernhard H Breier

    Citation: Nutrition & Metabolism 2014 11:50

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  2. Content type: Research

    Lysine supplementation may have a positive influence on the regulation of glucose metabolism but it has not been tested in the geriatric population. Objective: We evaluated the impact of acute lysine supplemen...

    Authors: Il-Young Kim, Rick H Williams, Scott E Schutzler, Cosby J Lasley, Donald L Bodenner, Robert R Wolfe and Robert H Coker

    Citation: Nutrition & Metabolism 2014 11:49

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  3. Content type: Research

    The association between smoking and total energy expenditure (TEE) is still controversial. We examined this association in a multi-country study where TEE was measured in a subset of participants by the doubly...

    Authors: Semira Gonseth, Lara Dugas, Barathi Viswanathan, Terrence Forrester, Vicki Lambert, Jacob Plange-Rhule, Ramon Durazo-Arvizu, Amy Luke, Dale A Schoeller and Pascal Bovet

    Citation: Nutrition & Metabolism 2014 11:48

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  4. Content type: Research

    The diminished ability of aged muscle to self-repair is a factor behind sarcopenia and contributes to muscle atrophy. Muscle repair depends on satellite cells whose pool size is diminished with aging. A reduct...

    Authors: Carla Domingues-Faria, Audrey Chanet, Jérôme Salles, Alexandre Berry, Christophe Giraudet, Véronique Patrac, Philippe Denis, Katia Bouton, Nicolas Goncalves-Mendes, Marie-Paule Vasson, Yves Boirie and Stéphane Walrand

    Citation: Nutrition & Metabolism 2014 11:47

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  5. Content type: Research

    The mammalian target of rapamycin (mTOR) pathway is the primary regulator of muscle protein synthesis. Metabolic syndrome (MetS) is characterized by central obesity and insulin resistance; little is known abou...

    Authors: Petra Gran, Amy E Larsen, Maxine Bonham, Aimee L Dordevic, Thusitha Rupasinghe, Claudio Silva, Amsha Nahid, Dedreia Tull, Andrew J Sinclair, Cameron J Mitchell and David Cameron-Smith

    Citation: Nutrition & Metabolism 2014 11:46

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  6. Content type: Research

    Previously, we reported that vitamin A-enriched diet (129 mg/kg diet) intake reduces the adiposity development in obese rats of WNIN/Ob strain. Here, we hypothesize that dose lesser than 129 mg of vitamin A/kg...

    Authors: Anamthathmakula Prashanth, Shanmugam M Jeyakumar, Lodhu Singotamu, Nemani Harishankar, Nappan V Giridharan and Ayyalasomayajula Vajreswari

    Citation: Nutrition & Metabolism 2014 11:45

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  7. Content type: Research

    Recent data suggest that an increased level of high-density lipoprotein cholesterol (HDL-C) is not causally protective against heart disease, shifting focus to other sub-phenotypes of HDL. Prior work on the ef...

    Authors: Daniel Seung Kim, Amber A Burt, Jane E Ranchalis, Leah E Jarvik, Jason F Eintracht, Clement E Furlong and Gail P Jarvik

    Citation: Nutrition & Metabolism 2014 11:44

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  8. Content type: Research

    Ingesting Yerba Maté (YM) has become widely popular for health promotion, obesity prevention and body weight reduction, primarily due its thermogenic effectiveness. However, the YM effects on fat metabolism du...

    Authors: Ahmad Alkhatib

    Citation: Nutrition & Metabolism 2014 11:42

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  9. Content type: Research

    Imidazoline I3 receptors (I-3R) can regulate insulin secretion in pancreatic β-cells. It has been indicated that allantoin ameliorates hyperglycemia by activating imidazoline I2 receptors (I-2R). Thus, the effect...

    Authors: Cheng-Chia Tsai, Li-Jen Chen, Ho-Shan Niu, Kun-Ming Chung, Juei-Tang Cheng and Kao-Chang Lin

    Citation: Nutrition & Metabolism 2014 11:41

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  10. Content type: Research

    Fasting is a rigorous type of dietary restriction that is associate with a number of health benefits. During fasting, ketone bodies significantly increase in blood and become major body fuels, thereby sparing ...

    Authors: Shigeru Nakamura, Ryuji Hisamura, Sachiko Shimoda, Izumi Shibuya and Kazuo Tsubota

    Citation: Nutrition & Metabolism 2014 11:40

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  11. Content type: Research

    Diet is an important component of type 2 diabetes therapy. Low adherence to current therapeutic diets points out to the need for alternative dietary approaches. This study evaluated the effect of a different d...

    Authors: Andreea Soare, Yeganeh M Khazrai, Rossella Del Toro, Elena Roncella, Lucia Fontana, Sara Fallucca, Silvia Angeletti, Valeria Formisano, Francesca Capata, Vladimir Ruiz, Carmen Porrata, Edlira Skrami, Rosaria Gesuita, Silvia Manfrini, Francesco Fallucca, Mario Pianesi…

    Citation: Nutrition & Metabolism 2014 11:39

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  12. Content type: Research

    Protein quality evaluation aims to determine the capacity of food sources and diets to meet protein and indispensable amino acid (IAA) requirements. This study determined whether nitrogen balance was affected ...

    Authors: Eveline A Martens, Sze-Yen Tan, Richard D Mattes and Margriet S Westerterp-Plantenga

    Citation: Nutrition & Metabolism 2014 11:38

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  13. Content type: Brief communication

    Lipase Maturation Factor 1 (LMF1) is an ER-chaperone involved in the post-translational maturation and catalytic activation of vascular lipases including lipoprotein lipase (LPL), hepatic lipase (HL) and endot...

    Authors: Nicole Ehrhardt, Candy Bedoya and Miklós Péterfy

    Citation: Nutrition & Metabolism 2014 11:37

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  14. Content type: Research

    Dietary fibre-induced satiety offers a physiological approach to body weight regulation, yet there is lack of scientific evidence. This experiment quantified food intake, body weight and body composition respo...

    Authors: Clare L Adam, Patricia A Williams, Matthew J Dalby, Karen Garden, Lynn M Thomson, Anthony J Richardson, Silvia W Gratz and Alexander W Ross

    Citation: Nutrition & Metabolism 2014 11:36

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  15. Content type: Research

    The exact mechanism of the protective role of Resveratrol (Res) in lipid metabolism and oxidative stress is not well elucidated. The present study aimed to investigate the potential benefits and possible mecha...

    Authors: Wei Zhu, Sifan Chen, Zilun Li, Xiaohong Zhao, Wenxue Li, Yanshuang Sun, Zili Zhang, Wenhua Ling and Xiang Feng

    Citation: Nutrition & Metabolism 2014 11:35

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  16. Content type: Research

    A moderate low-carbohydrate diet has been receiving attention in the dietary management of type 2 diabetes (T2DM). A fundamental issue has still to be addressed; how much carbohydrate delta-reduction (Δcarbohy...

    Authors: Hajime Haimoto, Tae Sasakabe, Takahiko Kawamura, Hiroyuki Umegaki, Masashi Komeda and Kenji Wakai

    Citation: Nutrition & Metabolism 2014 11:33

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  17. Content type: Research

    Obesity is a major risk factor for insulin resistance, type 2 diabetes, and stroke. Flavonoids are effective antioxidants that protect against these chronic diseases. In this study, we evaluated the effects of...

    Authors: Rie Tsutsumi, Tomomi Yoshida, Yoshitaka Nii, Naoki Okahisa, Shinya Iwata, Masao Tsukayama, Rei Hashimoto, Yasuko Taniguchi, Hiroshi Sakaue, Toshio Hosaka, Emi Shuto and Tohru Sakai

    Citation: Nutrition & Metabolism 2014 11:32

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  18. Content type: Review

    Prostate cancer is the second most common cause of cancer worldwide after lung cancer. There is increasing evidence that diet and lifestyle plays a crucial role in prostate cancer biology and tumourigenesis. P...

    Authors: Dalvinder Mandair, Roberta Elisa Rossi, Marinos Pericleous, Tara Whyand and Martyn Evan Caplin

    Citation: Nutrition & Metabolism 2014 11:30

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  19. Content type: Research

    The lipid messenger phosphatidic acid (PA) plays a critical role in the stimulation of mTOR signaling. However, the mechanism by which PA stimulates mTOR is currently unknown. Therefore, the purpose of this st...

    Authors: Jordan M Joy, David M Gundermann, Ryan P Lowery, Ralf Jäger, Sean A McCleary, Martin Purpura, Michael D Roberts, Stephanie MC Wilson, Troy A Hornberger and Jacob M Wilson

    Citation: Nutrition & Metabolism 2014 11:29

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  20. Content type: Research

    A high-fat diet promotes postprandial systemic inflammation and metabolic endotoxemia. We investigated the effects of three consecutive high-fat meals on endotoxemia, inflammation, vascular function, and postp...

    Authors: Mariann I Lassenius, Ville-Petteri Mäkinen, Christopher L Fogarty, Lina Peräneva, Matti Jauhiainen, Pirkko J Pussinen, Marja-Riitta Taskinen, Juha Kirveskari, Outi Vaarala, Janne K Nieminen, Sohvi Hörkkö, Antti J Kangas, Pasi Soininen, Mika Ala-Korpela, Daniel Gordin, Aila J Ahola…

    Citation: Nutrition & Metabolism 2014 11:28

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  21. Content type: Review

    Detrimental effects of acute and chronic alcohol (ethanol) consumption on human physiology are well documented in the literature. These adversely influence neural, metabolic, cardiovascular, and thermoregulato...

    Authors: Antonino Bianco, Ewan Thomas, Francesco Pomara, Garden Tabacchi, Bettina Karsten, Antonio Paoli and Antonio Palma

    Citation: Nutrition & Metabolism 2014 11:26

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    The Retraction Note to this article has been published in Nutrition & Metabolism 2014 11:43

  22. Content type: Research

    Obesity is associated with development of the cardiorenal metabolic syndrome, which is a constellation of risk factors, such as insulin resistance, inflammatory response, dyslipidemia, and high blood pressure ...

    Authors: Amanda Roberta de Almeida, Sarah Monte-Alegre, Michele Bianca Zanini, Aglécio Luiz Souza, Maurício Etchebehere and José Antonio Rocha Gontijo

    Citation: Nutrition & Metabolism 2014 11:25

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  23. Content type: Research

    Diets rich in dairy and/or calcium (Ca) have been associated with reductions in adiposity and inflammation, but the mechanisms underlying this remain to be fully elucidated. Oxylipins and endocannabinoids are ...

    Authors: Tamara N Dunn, Alison H Keenan, Anthony P Thomas, John W Newman and Sean H Adams

    Citation: Nutrition & Metabolism 2014 11:24

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  24. Content type: Research

    Individuals with cerebral palsy (CP) are at risk for nutritional insufficiency. The purpose of the study was to examine the vitamin D status of adults with CP, and to evaluate the association between vitamin D...

    Authors: Mark D Peterson, Heidi J Haapala, Ashish Chaddha and Edward A Hurvitz

    Citation: Nutrition & Metabolism 2014 11:22

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  25. Content type: Research

    Increased cellular iron exposure is associated with colorectal cancer (CRC) risk. Hepcidin, a liver peptide hormone, acts as the primary regulator of systemic iron status by blocking iron release from enterocy...

    Authors: Cenk K Pusatcioglu, Elizabeta Nemeth, Giamila Fantuzzi, Xavier Llor, Sally Freels, Lisa Tussing-Humphreys, Robert J Cabay, Rose Linzmeier, Damond Ng, Julia Clark and Carol Braunschweig

    Citation: Nutrition & Metabolism 2014 11:21

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  26. Content type: Research

    Marine derived oils are rich in long-chain polyunsaturated omega-3 fatty acids, in particular eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which have long been associated with health promoting e...

    Authors: Veronika Tillander, Bodil Bjørndal, Lena Burri, Pavol Bohov, Jon Skorve, Rolf K Berge and Stefan EH Alexson

    Citation: Nutrition & Metabolism 2014 11:20

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  27. Content type: Research

    We examined if a purported anti-inflammatory supplement (AF) abrogated Western-diet (WD)-induced liver pathology in rats. AF contained: 1) protein concentrates from bovine colostrum and avian egg yolk; 2) herb...

    Authors: C Brooks Mobley, Ryan G Toedebusch, Christopher M Lockwood, Alexander J Heese, Conan Zhu, Anna E Krieger, Clayton L Cruthirds, John C Hofheins, Joseph M Company, Charles E Wiedmeyer, Dae Y Kim, Frank W Booth and Michael D Roberts

    Citation: Nutrition & Metabolism 2014 11:19

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  28. Content type: Research

    Toll-like receptor 4 (TLR-4) is crucial in maintaining intestinal epithelial homeostasis, participates in a vigorous signaling process and heightens inflammatory cytokine output. The objective of this study wa...

    Authors: Igor Sukhotnik, Yulia Pollak, Arnold G Coran, Janna Pilatov, Jacob Bejar, Jorge G Mogilner and Drora Berkowitz

    Citation: Nutrition & Metabolism 2014 11:17

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  29. Content type: Brief communication

    Vitamin D, which influences cellular proliferation and breast tissue characteristics, has been inversely correlated with breast cancer risk. Dietary vitamin D intake has been associated with lower mammographic...

    Authors: Katherine D Crew, Julie Campbell, Diane Reynolds, Loralee Fulton, Julie D Flom, Yuyan Liao, Parisa Tehranifar and Mary Beth Terry

    Citation: Nutrition & Metabolism 2014 11:18

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  30. Content type: Research

    Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate...

    Authors: Mayara Franzoi Moreno, Gabriel Inácio de Morais Honorato de Souza, Ana Claudia Losinskas Hachul, Bruno dos Santos, Marcos Hiromu Okuda, Nelson Inácio Pinto Neto, Valter Tadeu Boldarine, Elisa Esposito, Eliane Beraldi Ribeiro, Claudia Maria da Penha Oller do Nascimento, Aline de Piano Ganen and Lila Missae Oyama

    Citation: Nutrition & Metabolism 2014 11:15

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  31. Content type: Research

    Miglitol is an oral anti-diabetic drug that acts by inhibiting carbohydrate absorption in the small intestine. Recent studies have shown that miglitol reduces obesity in humans and rodents. However, its mechan...

    Authors: Satoru Sugimoto, Hisakazu Nakajima, Kazuki Kodo, Jun Mori, Kensuke Matsuo, Kitaro Kosaka, Wataru Aoi, Kanji Yoshimoto, Hiroshi Ikegaya and Hajime Hosoi

    Citation: Nutrition & Metabolism 2014 11:14

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  32. Content type: Reviewer acknowledgement

    We and the Editorial Board acknowledge and thank all reviewers for their active participation and contribution during 2013. We greatly appreciate their dedication and behind the scenes contribution. It is larg...

    Authors: Lucy Abel, Ahmed Bakillah and M Mahmood Hussain

    Citation: Nutrition & Metabolism 2014 11:7

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  33. Content type: Research

    It may be useful to examine associations of fat intakes with total mortality as a basis for dietary recommendations. We aimed to elucidate associations between dietary fat and total mortality among Japanese po...

    Authors: Kenji Wakai, Mariko Naito, Chigusa Date, Hiroyasu Iso and Akiko Tamakoshi

    Citation: Nutrition & Metabolism 2014 11:12

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  34. Content type: Review

    Metabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty acids) oxidation based on nutrient availability. The ability to alter substrate oxidation in response to nutritiona...

    Authors: Shuai Zhang, Matthew W Hulver, Ryan P McMillan, Mark A Cline and Elizabeth R Gilbert

    Citation: Nutrition & Metabolism 2014 11:10

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  35. Content type: Research

    Lupin proteins exert hypocholesterolemic effects in man and animals, although the underlying mechanism remains uncertain. Herein we investigated whether lupin proteins compared to casein modulate sterol excret...

    Authors: Juliane Radtke, Stefanie Geissler, Alexandra Schutkowski, Corinna Brandsch, Holger Kluge, Marcello M Duranti, Sylvia Keller, Gerhard Jahreis, Frank Hirche and Gabriele I Stangl

    Citation: Nutrition & Metabolism 2014 11:9

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  36. Content type: Research

    Increased oxidative stress and inflammatory mediators are implicated in the development of diabetic retinopathy, and in rats, its development can be prevented by antioxidants. Carotenoids are some of the power...

    Authors: Renu A Kowluru, Qing Zhong, Julia M Santos, Mangayarkarasi Thandampallayam, Doug Putt and Dennis L Gierhart

    Citation: Nutrition & Metabolism 2014 11:8

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  37. Content type: Research

    Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been shown to alleviate the symptoms of metabolic disorders, such as heart disease, diabetes, obesity and insulin resistance. Several putative mechanisms by whi...

    Authors: Abeer A Ahmed, Kayode A Balogun, Natalia V Bykova and Sukhinder K Cheema

    Citation: Nutrition & Metabolism 2014 11:6

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  38. Content type: Review

    As a minor component of vitamin E, tocotrienols were evident in exhibiting biological activities such as neuroprotection, radio-protection, anti-cancer, anti-inflammatory and lipid lowering properties which ar...

    Authors: Ju-Yen Fu, Hui-Ling Che, Doryn Meam-Yee Tan and Kim-Tiu Teng

    Citation: Nutrition & Metabolism 2014 11:5

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  39. Content type: Research

    Accumulating evidence suggests a role for silicon in optimal connective tissue health. Further proof of its importance/essentiality may be provided by studies involving imposed depletion followed by 29Si challeng...

    Authors: Supannee Pruksa, Atitaya Siripinyanond, Jonathan J Powell and Ravin Jugdaohsingh

    Citation: Nutrition & Metabolism 2014 11:4

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  40. Content type: Research

    Changes of gastrointestinal motility, which are important related to the food digestion and absorption in the gastrointestinal tract, may be one of the factors in obesity-formation.

    Authors: Xiao-Yi Fu, Ze Li, Na Zhang, Hai-Tao Yu, Shu-Ran Wang and Jia-Ren Liu

    Citation: Nutrition & Metabolism 2014 11:3

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  41. Content type: Research

    Renal interstitial fibrosis is a common final pathological process in the progression of kidney disease. This is primarily due to oxidative stress, which contributes to renal inflammation and fibrosis. Nuclear...

    Authors: Sungjin Chung, Hye Eun Yoon, Soo Jeong Kim, Sung Jun Kim, Eun Sil Koh, Yu Ah Hong, Cheol Whee Park, Yoon Sik Chang and Seok Joon Shin

    Citation: Nutrition & Metabolism 2014 11:2

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  42. Content type: Research

    Phenolic acids are covalently bound to the arabinoxylan fibre matrix of wheat aleurone layer. In order to be bioavailable they need to be released by endogenous or bacterial enzymes and absorbed within the int...

    Authors: Jenna Pekkinen, Natalia N Rosa, Otto-Ilari Savolainen, Pekka Keski-Rahkonen, Hannu Mykkänen, Kaisa Poutanen, Valérie Micard and Kati Hanhineva

    Citation: Nutrition & Metabolism 2014 11:1

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