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  1. Content type: Research

    Recent studies in animal models, based on the hypothesis that malignant glioma cells are more dependent on glycolysis for energy generation, have shown promising results using ketogenic diet (KD) therapy as an...

    Authors: Howard T Chang, Lawrence Karl Olson and Kenneth A Schwartz

    Citation: Nutrition & Metabolism 2013 10:47

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  2. Content type: Review

    Whether dietary fructose (as sucrose or high fructose corn syrup) has unique effects separate from its role as carbohydrate, or, in fact, whether it can be considered inherently harmful, even a toxin, has assu...

    Authors: Richard D Feinman and Eugene J Fine

    Citation: Nutrition & Metabolism 2013 10:45

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  3. Content type: Research

    The human diet has altered markedly during the past four decades, with the introduction of Trans hydrogenated fat, which extended the shelf-life of dietary oils and promoted a dramatic increase in elaidic acid (T...

    Authors: Kate S Collison, Nadine J Makhoul, Marya Z Zaidi, Angela Inglis, Bernard L Andres, Rosario Ubungen, Soad Saleh and Futwan A Al-Mohanna

    Citation: Nutrition & Metabolism 2013 10:44

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  4. Content type: Research

    Although evidence indicates that fatty acids (FA) can affect insulin resistance (IR), not all FA contribute equally to the process. Indeed, monounsaturated FA (MUFA) and polyunsaturated FA (PUFA) are reported ...

    Authors: Jessica C Ralston, Michael A Zulyniak, Daiva E Nielsen, Shannon Clarke, Alaa Badawi, Ahmed El-Sohemy, David WL Ma and David M Mutch

    Citation: Nutrition & Metabolism 2013 10:42

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  5. Content type: Research

    Supplementation studies have suggested a role of n-3 polyunsaturated fatty acids (PUFAs) in homocysteine metabolism, but the evidence is limited and inconsistent among studies that measured blood levels of n-3...

    Authors: Ayami Kume, Kayo Kurotani, Masao Sato, Yuko Ejima, Ngoc Minh Pham, Akiko Nanri, Keisuke Kuwahara and Tetsuya Mizoue

    Citation: Nutrition & Metabolism 2013 10:41

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  6. Content type: Research

    The cardiovascular (CV) and metabolic health benefits or risks associated with consumption of multi-ingredient performance supplements (MIPS) in conjunction with periodized resistance training (RT) in resistan...

    Authors: Michael J Ormsbee, Dennison David Thomas, William Kyle Mandler, Emery G Ward, Amber W Kinsey, Lynn B Panton, Timothy P Scheett, Shirin Hooshmand, Emily Simonavice and Jeong-Su Kim

    Citation: Nutrition & Metabolism 2013 10:39

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  7. Content type: Research

    Both exercise and vitamin E supplementation have been shown to reduce oxidative stress and cardiovascular disease risk in older adults, and when combined there is evidence suggesting that they act synergistica...

    Authors: Jong-Hwan Park, Masashi Miyashita, Masaki Takahashi, Noriaki Kawanishi, Seong-Ryu Bae, Hyun-Shik Kim, Katsuhiko Suzuki and Yoshio Nakamura

    Citation: Nutrition & Metabolism 2013 10:38

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  8. Content type: Research

    Monomethylsilanetriol (MMST) has been used for decades as an oral silicon supplement for bone and connective tissue health, although there are no formal data on its in vivo utilisation or safety following sustain...

    Authors: Ravin Jugdaohsingh, Maio Hui, Simon HC Anderson, Stephen D Kinrade and Jonathan J Powell

    Citation: Nutrition & Metabolism 2013 10:37

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  9. Content type: Brief communication

    Total fat and omega-3 fatty acids in the diet may affect breast cancer risk by altering estrogen metabolism. The purpose of this study was to elucidate the effects of differing total fat and omega-3 fatty acid...

    Authors: Lindsay R Young, Susan K Raatz, William Thomas, J Bruce Redmon and Mindy S Kurzer

    Citation: Nutrition & Metabolism 2013 10:36

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  10. Content type: Research

    Type 2 diabetes mellitus (DM), characterized by peripheral insulin resistance, is the most common form of diabetes. Probiotics are live micro-organisms that, when administered in adequate amounts, confer delay...

    Authors: Feng-Ching Hsieh, Chia-Lin Lee, Chee-Yin Chai, Wan-Tzu Chen, Ying-Chen Lu and Ching-Shuang Wu

    Citation: Nutrition & Metabolism 2013 10:35

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  11. Content type: Review

    Gaucher disease (GD) type I is the most common type of GD. Its main clinical manifestations are hepatosplenomegaly as well as bone and hematological abnormalities. The objective of the present study was to per...

    Authors: Divair Doneda, Cristina B Netto, Cileide C Moulin and Ida Vanessa D Schwartz

    Citation: Nutrition & Metabolism 2013 10:34

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  12. Content type: Research

    Glucagon-like Peptide-1 (GLP-1) is an incretin hormone secreted from the gastrointestinal tract that facilitates the glucose-dependent insulin response. Additionally, GLP-1 is thought to be involved in energy ...

    Authors: Danny Wadden, Farrell Cahill, Peyvand Amini, Edward Randell, Sudesh Vasdev, Yanqing Yi, Jon Church and Guang Sun

    Citation: Nutrition & Metabolism 2013 10:33

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  13. Content type: Research

    Fructose produces hepatic insulin resistance in humans and animals. We have proposed that the selective metabolism of fructose by the liver can, under conditions of elevated fructose delivery, inflict a metabo...

    Authors: Yuren Wei, Dong Wang, Gretchen Moran, Andrea Estrada and Michael J Pagliassotti

    Citation: Nutrition & Metabolism 2013 10:32

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  14. Content type: Review

    Lipid metabolic disorder is a critical risk factor for metabolic syndrome, triggering debilitating diseases like obesity and diabetes. Both obesity and diabetes are the epicenter of important medical issues, r...

    Authors: Sarwar Hashmi, Yi Wang, Ranjit S Parhar, Kate S Collison, Walter Conca, Futwan Al-Mohanna and Randy Gaugler

    Citation: Nutrition & Metabolism 2013 10:31

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  15. Content type: Research

    Metabolic syndrome has become a major public health concern, but the role of diet in the etiology of this syndrome is not well understood. This study investigated the association between major dietary patterns...

    Authors: Shamima Akter, Akiko Nanri, Ngoc Minh Pham, Kayo Kurotani and Tetsuya Mizoue

    Citation: Nutrition & Metabolism 2013 10:30

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  16. Content type: Research

    Obesity is associated with low-grade inflammation and impaired immune response. Caloric restriction (CR) has been shown to inhibit inflammatory response and enhance cell-mediated immune function. Curcumin, the...

    Authors: Junpeng Wang, Sally M Vanegas, Xiaogang Du, Timothy Noble, Jean-Marc A Zingg, Mohsen Meydani, Simin Nikbin Meydani and Dayong Wu

    Citation: Nutrition & Metabolism 2013 10:29

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  17. Content type: Research

    Recently, it has been shown that carnitine down-regulates genes involved in the ubiquitin-proteasome system (UPS) in muscle of pigs and rats. The mechanisms underlying this observation are yet unknown. Based o...

    Authors: Janine Keller, Aline Couturier, Melanie Haferkamp, Erika Most and Klaus Eder

    Citation: Nutrition & Metabolism 2013 10:28

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  18. Content type: Research

    Soy oil is a major vegetable oil consumed in the US. A recently developed soybean variety produces oil with a lower concentration of α-linolenic acid, hence a higher (n-6)/(n-3) ratio, than regular soy oil. Th...

    Authors: Ramesh B Potu, Hang Lu, Olayiwola Adeola and Kolapo M Ajuwon

    Citation: Nutrition & Metabolism 2013 10:27

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  19. Content type: Research

    Tissue concentrations of fatty acids (FAs) and genetic variations are well-known factors which affect the cardiovascular disease (CVD) risk. The objective was to examine whether the genetic variability of 20 c...

    Authors: Iwona Rudkowska, Catherine Ouellette, Eric Dewailly, Robert A Hegele, Véronique Boiteau, Ariane Dubé-Linteau, Belkacem Abdous, Françoise Proust, Yves Giguère, Pierre Julien, Marie-Ludivine Château-Degat and Marie-Claude Vohl

    Citation: Nutrition & Metabolism 2013 10:26

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  20. Content type: Research

    Visceral fat accumulation is caused by over-nutrition and physical inactivity. Excess accumulation of visceral fat associates with atherosclerosis. Polyunsaturated fatty acids have an important role in human n...

    Authors: Kana Inoue, Ken Kishida, Ayumu Hirata, Tohru Funahashi and Iichiro Shimomura

    Citation: Nutrition & Metabolism 2013 10:25

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  21. Content type: Research

    Dietary intake of n-3 polyunsaturated fatty acids (PUFA) is primarily recognized to protect against cardiovascular diseases, cognitive dysfunctions and the onset of obesity and associated metabolic disorders. How...

    Authors: Manar Awada, Anne Meynier, Christophe O Soulage, Lilas Hadji, Alain Géloën, Michèle Viau, Lucie Ribourg, Berengère Benoit, Cyrille Debard, Michel Guichardant, Michel Lagarde, Claude Genot and Marie-Caroline Michalski

    Citation: Nutrition & Metabolism 2013 10:23

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  22. Content type: Research

    Dietary strategies seem to be the most prescribed therapy in order to counteract obesity regarding not only calorie restriction, but also bioactive ingredients and the composition of the consumed foods. Dietar...

    Authors: Patricia Lopez-Legarrea, Rocio de la Iglesia, Itziar Abete, Isabel Bondia-Pons, Santiago Navas-Carretero, Lluis Forga, J Alfredo Martinez and M Angeles Zulet

    Citation: Nutrition & Metabolism 2013 10:22

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  23. Content type: Research

    Obesity and related morbidities are reaching epidemic proportions in the Arab populations. Possible mechanisms that link obesity/visceral fat to diabetes and cardiovascular (CVD) complications include inflamma...

    Authors: Salah Gariballa, Bachar Afandi, Mamoun AbuHaltem, Javed Yassin, Hosam Habib and Wissam Ibrahim

    Citation: Nutrition & Metabolism 2013 10:21

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  24. Content type: Research

    This study investigated the protective effects of melatonin and folic acid against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Oxidative stress, liver function, liver histopathology and serum l...

    Authors: Hossam Ebaid, Samir AE Bashandy, Ibrahim M Alhazza, Ahmed Rady and Sultan El-Shehry

    Citation: Nutrition & Metabolism 2013 10:20

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  25. Content type: Research

    Phenolic compounds combine antioxidant and hypocholesterolemic activities and, consequently, are expected to prevent or minimize cardiometabolic risk.

    Authors: Milessa S Afonso, Ana Mara de O Silva, Eliane BT Carvalho, Diogo P Rivelli, Sílvia BM Barros, Marcelo M Rogero, Ana Maria Lottenberg, Rosângela P Torres and Jorge Mancini-Filho

    Citation: Nutrition & Metabolism 2013 10:19

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  26. Content type: Research

    Patients with inflammatory bowel disease (IBD) frequently appear iron deplete but whether this is a reflection of dietary iron intakes is not known.

    Authors: Jonathan J Powell, William B Cook, Mark Chatfield, Carol Hutchinson, Dora IA Pereira and Miranda CE Lomer

    Citation: Nutrition & Metabolism 2013 10:18

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  27. Content type: Research

    The objective of present study was to examine the effect of long-chain monounsaturated fatty acids (LC-MUFAs) with chain lengths longer than 18 (i.e., C20:1 and C22:1 isomers combined) on obesity-related metab...

    Authors: Zhi-Hong Yang, Hiroko Miyahara, Yusuke Iwasaki, Jiro Takeo and Masashi Katayama

    Citation: Nutrition & Metabolism 2013 10:16

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  28. Content type: Research

    A blunted muscle protein synthetic response to protein ingestion may contribute to the age related loss of muscle tissue. We hypothesized that the greater endogenous insulin release following co-ingestion of c...

    Authors: Henrike M Hamer, Benjamin T Wall, Alexandra Kiskini, Anneke de Lange, Bart B L Groen, Jaap A Bakker, Annemie P Gijsen, Lex B Verdijk and Luc J C van Loon

    Citation: Nutrition & Metabolism 2013 10:15

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  29. Content type: Research

    Butyrate is known as histone deacetylase inhibitor, inducing histone hyperacetylation in vitro and playing a predominant role in the epigenetic regulation of gene expression and cell function. We hypothesized tha...

    Authors: Gábor Mátis, Zsuzsanna Neogrády, György Csikó, Anna Kulcsár, Ákos Kenéz and Korinna Huber

    Citation: Nutrition & Metabolism 2013 10:12

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  30. Content type: Brief communication

    GPR43 is a G-protein-coupled receptor that participates in adipocyte differentiation in mice and is over-expressed in adipose tissue of obese mice. The aim of this study was to investigate the implication of G...

    Authors: Evelyne M Dewulf, Qian Ge, Laure B Bindels, Florence M Sohet, Patrice D Cani, Sonia M Brichard and Nathalie M Delzenne

    Citation: Nutrition & Metabolism 2013 10:11

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  31. Content type: Research

    Iron deficiency anaemia and oral iron supplementation have been associated negatively with quality of life, and with adverse effects, respectively, in subjects with inflammatory bowel disease (IBD). Hence, the...

    Authors: Jonathan J Powell, William B Cook, Carol Hutchinson, Zoe Tolkien, Mark Chatfield, Dora I A Pereira and Miranda C E Lomer

    Citation: Nutrition & Metabolism 2013 10:9

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  32. Content type: Letter to the Editor

    Citation: Nutrition & Metabolism 2013 10:10

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  33. Content type: Research

    Metabolic flexibility described as “the capacity of the body to match fuel oxidation to fuel availability” has been implicated in insulin resistance. We examined fasting substrate oxidation in relation to diet...

    Authors: Madelaine T Carstens, Julia H Goedecke, Lara Dugas, Juliet Evans, Jacolene Kroff, Naomi S Levitt and Estelle V Lambert

    Citation: Nutrition & Metabolism 2013 10:8

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  34. Content type: Research

    Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited ...

    Authors: Ulkan Kilic, Ertugrul Kilic, Zeynep Tuzcu, Mehmet Tuzcu, Ibrahim H Ozercan, Okkes Yilmaz, Fikrettin Sahin and Kazim Sahin

    Citation: Nutrition & Metabolism 2013 10:7

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  35. Content type: Research

    Intestinal derived endotoxin and the subsequent endotoxemia can be considered major predisposing factors for diseases such as atherosclerosis, sepsis, obesity and diabetes. Dietary fat has been shown to increa...

    Authors: Venkatesh Mani, James H Hollis and Nicholas K Gabler

    Citation: Nutrition & Metabolism 2013 10:6

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  36. Content type: Research

    We investigated if whether intrauterine protein restriction in combination with overfeeding during lactation would cause adult-onset obesity and metabolic disorders. After birth, litters from dams fed with con...

    Authors: Grazielle Vitória Ponti Coutinho, Felipe Rodrigues Coutinho, Jaline Zandonato Faiad, Marina Satie Taki, Silvia Regina de Lima Reis, Letícia Martins Ignácio-Souza, Adriene Alexandra Paiva, Márcia Queiroz Latorraca, Maria Helena Gaíva Gomes-da-Silva and Maria Salete Ferreira Martins

    Citation: Nutrition & Metabolism 2013 10:5

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  37. Content type: Research

    PCSK9 (Proprotein Convertase Subtilisin Kexin type 9) is a circulating protein that promotes hypercholesterolemia by decreasing hepatic LDL receptor protein. Under non interventional conditions, its expression...

    Authors: Bertrand Cariou, Cédric Langhi, Maëlle Le Bras, Murielle Bortolotti, Kim-Anne Lê, Fanny Theytaz, Cédric Le May, Béatrice Guyomarc’h-Delasalle, Yassine Zaïr, Roland Kreis, Chris Boesch, Michel Krempf, Luc Tappy and Philippe Costet

    Citation: Nutrition & Metabolism 2013 10:4

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  38. Content type: Review

    Silicon (Si) is the most abundant element present in the Earth's crust besides oxygen. However, the exact biological roles of silicon remain unknown. Moreover, the ortho-silicic acid (H4SiO4), as a major form of ...

    Authors: Lela Munjas Jurkić, Ivica Cepanec, Sandra Kraljević Pavelić and Krešimir Pavelić

    Citation: Nutrition & Metabolism 2013 10:2

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  39. Content type: Research

    Risk for obesity differs with ethnicity/race and is associated with insulin sensitivity (SI), insulin responsiveness, and dietary glycemic load (GL). The objective of this study was to test the hypotheses that, 1...

    Authors: Barbara A Gower, Jessica A Alvarez, Nikki C Bush and Gary R Hunter

    Citation: Nutrition & Metabolism 2013 10:3

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  40. Content type: Research

    Jerusalem artichoke (Helianthus tuberosus Linne, HTL) and chungkookjang (CKJ; fermented soybeans) both modulate energy and glucose metabolism. However, the mechanism and their additive effects are unknown. We inv...

    Authors: Hye Jeong Yang, Dae Young Kwon, Min Jung Kim, Suna Kang, Da Sol Kim and Sunmin Park

    Citation: Nutrition & Metabolism 2012 9:112

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  41. Content type: Research

    In Lebanon, Type 2 diabetes (T2D) has a major public health impact through high disease prevalence, significant downstream pathophysiologic effects, and enormous financial liabilities. Diet is an important env...

    Authors: Farah Naja, Nahla Hwalla, Leila Itani, Maya Salem, Sami T Azar, Maya Nabhani Zeidan and Lara Nasreddine

    Citation: Nutrition & Metabolism 2012 9:111

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