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  1. Butyrate is known as histone deacetylase inhibitor, inducing histone hyperacetylation in vitro and playing a predominant role in the epigenetic regulation of gene expression and cell function. We hypothesized tha...

    Authors: Gábor Mátis, Zsuzsanna Neogrády, György Csikó, Anna Kulcsár, Ákos Kenéz and Korinna Huber
    Citation: Nutrition & Metabolism 2013 10:12
  2. GPR43 is a G-protein-coupled receptor that participates in adipocyte differentiation in mice and is over-expressed in adipose tissue of obese mice. The aim of this study was to investigate the implication of G...

    Authors: Evelyne M Dewulf, Qian Ge, Laure B Bindels, Florence M Sohet, Patrice D Cani, Sonia M Brichard and Nathalie M Delzenne
    Citation: Nutrition & Metabolism 2013 10:11
  3. See related article: http://​www.​nutritionandmeta​bolism.​com/​content/​10/​1/​14

    Authors: Tonkla Insawang, Carlo Selmi, Ubon Cha’on, M Eric Gershwin, Puangrat Yongvanit and Vitoon Prasongwattana
    Citation: Nutrition & Metabolism 2013 10:10
  4. Iron deficiency anaemia and oral iron supplementation have been associated negatively with quality of life, and with adverse effects, respectively, in subjects with inflammatory bowel disease (IBD). Hence, the...

    Authors: Jonathan J Powell, William B Cook, Carol Hutchinson, Zoe Tolkien, Mark Chatfield, Dora I A Pereira and Miranda C E Lomer
    Citation: Nutrition & Metabolism 2013 10:9
  5. Metabolic flexibility described as “the capacity of the body to match fuel oxidation to fuel availability” has been implicated in insulin resistance. We examined fasting substrate oxidation in relation to diet...

    Authors: Madelaine T Carstens, Julia H Goedecke, Lara Dugas, Juliet Evans, Jacolene Kroff, Naomi S Levitt and Estelle V Lambert
    Citation: Nutrition & Metabolism 2013 10:8
  6. Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies. However, the chemotherapeutic use of cisplatin is limited ...

    Authors: Ulkan Kilic, Ertugrul Kilic, Zeynep Tuzcu, Mehmet Tuzcu, Ibrahim H Ozercan, Okkes Yilmaz, Fikrettin Sahin and Kazim Sahin
    Citation: Nutrition & Metabolism 2013 10:7
  7. Intestinal derived endotoxin and the subsequent endotoxemia can be considered major predisposing factors for diseases such as atherosclerosis, sepsis, obesity and diabetes. Dietary fat has been shown to increa...

    Authors: Venkatesh Mani, James H Hollis and Nicholas K Gabler
    Citation: Nutrition & Metabolism 2013 10:6
  8. We investigated if whether intrauterine protein restriction in combination with overfeeding during lactation would cause adult-onset obesity and metabolic disorders. After birth, litters from dams fed with con...

    Authors: Grazielle Vitória Ponti Coutinho, Felipe Rodrigues Coutinho, Jaline Zandonato Faiad, Marina Satie Taki, Silvia Regina de Lima Reis, Letícia Martins Ignácio-Souza, Adriene Alexandra Paiva, Márcia Queiroz Latorraca, Maria Helena Gaíva Gomes-da-Silva and Maria Salete Ferreira Martins
    Citation: Nutrition & Metabolism 2013 10:5
  9. PCSK9 (Proprotein Convertase Subtilisin Kexin type 9) is a circulating protein that promotes hypercholesterolemia by decreasing hepatic LDL receptor protein. Under non interventional conditions, its expression...

    Authors: Bertrand Cariou, Cédric Langhi, Maëlle Le Bras, Murielle Bortolotti, Kim-Anne Lê, Fanny Theytaz, Cédric Le May, Béatrice Guyomarc’h-Delasalle, Yassine Zaïr, Roland Kreis, Chris Boesch, Michel Krempf, Luc Tappy and Philippe Costet
    Citation: Nutrition & Metabolism 2013 10:4
  10. Risk for obesity differs with ethnicity/race and is associated with insulin sensitivity (SI), insulin responsiveness, and dietary glycemic load (GL). The objective of this study was to test the hypotheses that, 1...

    Authors: Barbara A Gower, Jessica A Alvarez, Nikki C Bush and Gary R Hunter
    Citation: Nutrition & Metabolism 2013 10:3
  11. Silicon (Si) is the most abundant element present in the Earth's crust besides oxygen. However, the exact biological roles of silicon remain unknown. Moreover, the ortho-silicic acid (H4SiO4), as a major form of ...

    Authors: Lela Munjas Jurkić, Ivica Cepanec, Sandra Kraljević Pavelić and Krešimir Pavelić
    Citation: Nutrition & Metabolism 2013 10:2
  12. Jerusalem artichoke (Helianthus tuberosus Linne, HTL) and chungkookjang (CKJ; fermented soybeans) both modulate energy and glucose metabolism. However, the mechanism and their additive effects are unknown. We inv...

    Authors: Hye Jeong Yang, Dae Young Kwon, Min Jung Kim, Suna Kang, Da Sol Kim and Sunmin Park
    Citation: Nutrition & Metabolism 2012 9:112
  13. In Lebanon, Type 2 diabetes (T2D) has a major public health impact through high disease prevalence, significant downstream pathophysiologic effects, and enormous financial liabilities. Diet is an important env...

    Authors: Farah Naja, Nahla Hwalla, Leila Itani, Maya Salem, Sami T Azar, Maya Nabhani Zeidan and Lara Nasreddine
    Citation: Nutrition & Metabolism 2012 9:111
  14. Leptin-deficient ob/ob mice exhibit adipocyte hypertrophy and hyperplasia as well as elevated adipose tissue and systemic inflammation. Multipotent stem cells isolated from adult adipose tissue can differentiate ...

    Authors: Zhou Zhou, Manish Neupane, Hui Ren Zhou, Dayong Wu, Chia-Cheng Chang, Naima Moustaid-Moussa and Kate J Claycombe
    Citation: Nutrition & Metabolism 2012 9:109
  15. High intakes of phytochemical-rich foods have favorable effects on the prevention of chronic diseases. In this study we assessed the dietary phytochemical index (PI) in relation to 3-year change in weight, wai...

    Authors: Parvin Mirmiran, Zahra Bahadoran, Mahdieh Golzarand, Niloofar Shiva and Fereidoun Azizi
    Citation: Nutrition & Metabolism 2012 9:108
  16. The study was performed to determine whether catch-up growth is associated with the development of insulin resistance and to explore serum endocrine markers associated with the metabolism of adipose tissue in ...

    Authors: Hong-Zhu Deng, Hong Deng, Zhe Su, Yan-Hong Li, Hua-Mei Ma, Hong-Shan Chen and Min-Lian Du
    Citation: Nutrition & Metabolism 2012 9:107
  17. Type 2 diabetes is associated with obesity, ectopic lipid accumulation and low-grade inflammation. A dysfunctional gut microbiota has been suggested to participate in the pathogenesis of the disease. Green tea...

    Authors: Ulrika Axling, Crister Olsson, Jie Xu, Céline Fernandez, Sara Larsson, Kristoffer Ström, Siv Ahrné, Cecilia Holm, Göran Molin and Karin Berger
    Citation: Nutrition & Metabolism 2012 9:105
  18. As a cellular energy sensor, the 5’AMP-activated protein kinase (AMPK) is activated in response to energy stresses such as hypoxia and muscle contraction. To determine effects of iron deficiency on AMPK activa...

    Authors: John F Merrill, David M Thomson, Shalene E Hardman, Squire D Hepworth, Shelby Willie and Chad R Hancock
    Citation: Nutrition & Metabolism 2012 9:104
  19. Inflammation and oxidative stress are associated with the development of numerous chronic diseases. Circulating ascorbic acid, α-tocopherol, and 25-hydroxyvitamin D (25(OH)D) may help reduce concentrations of ...

    Authors: Bibiana García-Bailo, Kaitlin Roke, David M Mutch, Ahmed El-Sohemy and Alaa Badawi
    Citation: Nutrition & Metabolism 2012 9:102
  20. Obesity is a common pathology with increasing incidence, and is associated with increased mortality and healthcare costs. Several treatment options for obesity are currently available ranging from behavioral m...

    Authors: Roger A Vaughan, Randi Garcia-Smith, Miguel A Barberena, Marco Bisoffi, Kristina Trujillo and Carole A Conn
    Citation: Nutrition & Metabolism 2012 9:101
  21. Diets producing a high glycemic response result in exaggerated insulin secretion which induces hepatic lipogenesis, contributing to development of insulin resistance and fatty liver. Viscous dietary fibers blu...

    Authors: David A Brockman, Xiaoli Chen and Daniel D Gallaher
    Citation: Nutrition & Metabolism 2012 9:100
  22. Early age at menarche is associated with increased risk of metabolic syndrome in both China and the West. However, little is known about the impact of age at menarche and metabolic syndrome in South Asian wome...

    Authors: Shamima Akter, Subrina Jesmin, Mazedul Islam, Sayeeda Nusrat Sultana, Osamu Okazaki, Michiaki Hiroe, Masao Moroi and Taro Mizutani
    Citation: Nutrition & Metabolism 2012 9:99
  23. The ability of an intermittent fasting (IF)-calorie restriction (CR) regimen (with or without liquid meals) to modulate adipokines in a way that is protective against coronary heart disease (CHD) has yet to be...

    Authors: Cynthia M Kroeger, Monica C Klempel, Surabhi Bhutani, John F Trepanowski, Christine C Tangney and Krista A Varady
    Citation: Nutrition & Metabolism 2012 9:98
  24. The soluble cell adhesion molecules and adipokines are elevated in patients with obesity, hypertension, type 2 diabetes mellitus, breast cancer and atherosclerosis.

    Authors: Caroline Isoppo de Souza, Daniela Dornelles Rosa, Betina Ettrich, Gabriela Hermann Cibeira, Juliana Giacomazzi, Paloma Tusset, Patrícia Ashton-Prolla, Lidia Rosi Medeiros, Maira Caleffi, Eurico Camargo Neto, Emilio Hideyuki Moriguchi and Marcia Silveira Graudenz
    Citation: Nutrition & Metabolism 2012 9:97
  25. Only protein diet has been used successfully to prevent loss of lean body mass first in post-surgical and then in obese patients. We studied overweight and obese patients receiving short treatments of an exclu...

    Authors: Gianfranco Cappello, Antonella Franceschelli, Annalisa Cappello and Paolo De Luca
    Citation: Nutrition & Metabolism 2012 9:96
  26. Previous studies examining the metabolic consequences of dietary iron deficiency have reported elevated serum glucose concentrations in iron-deficient animals. Importantly, the majority of these findings were ...

    Authors: McKale R Davis, Kristen K Hester, Krista M Shawron, Edralin A Lucas, Brenda J Smith and Stephen L Clarke
    Citation: Nutrition & Metabolism 2012 9:95
  27. Endocrine FGF19 and FGF21 exert their effects on metabolic homeostasis through fibroblast growth factor receptor (FGFR) and co-factor betaKlotho (KLB). Ileal FGF19 regulates bile acid metabolism through specif...

    Authors: Chaofeng Yang, Cong Wang, Min Ye, Chengliu Jin, Weimin He, Fen Wang, Wallace L McKeehan and Yongde Luo
    Citation: Nutrition & Metabolism 2012 9:94
  28. Animal studies show that diets containing resistant starch (RS) at levels not achievable in the human diet result in lower body weight and/or adiposity in rodents. We aimed to determine whether RS dose-depende...

    Authors: Damien P Belobrajdic, Roger A King, Claus T Christophersen and Anthony R Bird
    Citation: Nutrition & Metabolism 2012 9:93
  29. Adolescence is an important life stage for the development of dietary preferences and health behaviour. Longitudinal studies indicated that cardiovascular status in adolescence predicts cardiovascular risk mar...

    Authors: Julia Truthmann, Almut Richter, Silke Thiele, Larissa Drescher, Jutta Roosen and Gert BM Mensink
    Citation: Nutrition & Metabolism 2012 9:92
  30. The pattern of protein intake following exercise may impact whole-body protein turnover and net protein retention. We determined the effects of different protein feeding strategies on protein metabolism in res...

    Authors: Daniel R Moore, Jose Areta, Vernon G Coffey, Trent Stellingwerff, Stuart M Phillips, Louise M Burke, Marilyn Cléroux, Jean-Philippe Godin and John A Hawley
    Citation: Nutrition & Metabolism 2012 9:91
  31. Calorie restriction (CR; ~60% of ad libitum, AL intake) has been associated with substantial alterations in body composition and insulin sensitivity. Recently, several proteins that are secreted by nontraditio...

    Authors: Naveen Sharma, Carlos M Castorena and Gregory D Cartee
    Citation: Nutrition & Metabolism 2012 9:90
  32. Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that include obesity, impaired glucose tolerance or diabetes, hyperinsulinemia, hypertension, and dyslipidemia. Recently, more attention ha...

    Authors: Enrico Marchetti, Annalisa Monaco, Laura Procaccini, Stefano Mummolo, Roberto Gatto, Stefano Tetè, Alberto Baldini, Simona Tecco and Giuseppe Marzo
    Citation: Nutrition & Metabolism 2012 9:88
  33. It is difficult to study the mechanisms of the metabolic syndrome in humans due to the heterogeneous genetic background and lifestyle. The present study investigated changes in the gene and protein profiles in...

    Authors: Jie Chang, Shinji Oikawa, Gaku Ichihara, Yui Nanpei, Yasuhiro Hotta, Yoshiji Yamada, Saeko Tada-Oikawa, Hitoshi Iwahashi, Emiko Kitagawa, Ichiro Takeuchi, Masao Yuda and Sahoko Ichihara
    Citation: Nutrition & Metabolism 2012 9:87
  34. DOR/TP53INP2 acts both at the chromosomal level as a nuclear co-factor e.g. for the thyroid hormone receptor and at the extrachromosomal level as an organizing factor of the autophagosome. In a previous study,...

    Authors: Carolin Fromm-Dornieden, Oleksandr Lytovchenko, Silvia von der Heyde, Nina Behnke, Sebastian Hogl, Janina Berghoff, Frederik Köpper, Lennart Opitz, Ulla Renne, Andreas Hoeflich, Tim Beissbarth, Bertram Brenig and Bernhard G Baumgartner
    Citation: Nutrition & Metabolism 2012 9:86
  35. The prevalence of obesity is increasing exponentially world over. Leptin resistance/hyperleptinemia is attributed to its cause in majority of the obese humans where mutation in genetic component or ob gene has...

    Authors: Satish Kumar Taneja, Reshu Mandal and Aman Chechi
    Citation: Nutrition & Metabolism 2012 9:85
  36. Oxidative stress plays an important role in diabetes-induced vascular inflammation and pathogenesis. Nuclear factor E2-related factor-2 (Nrf2) is a transcription factor orchestrating antioxidant and cyto-prote...

    Authors: Xiao Miao, Yang Bai, Weixia Sun, Wenpeng Cui, Ying Xin, Yuehui Wang, Yi Tan, Lining Miao, Yaowen Fu, Guanfang Su and Lu Cai
    Citation: Nutrition & Metabolism 2012 9:84
  37. Caloric restriction is one of the most efficient ways to promote weight loss and is known to activate protective metabolic pathways. Frequently reported with weight loss is the undesirable consequence of fat f...

    Authors: Cassandra M McIver, Thomas P Wycherley and Peter M Clifton
    Citation: Nutrition & Metabolism 2012 9:83
  38. The Daniel Fast is a vegan diet that prohibits the consumption of animal products, refined foods, white flour, preservatives, additives, sweeteners, flavorings, caffeine, and alcohol. Following this dietary pl...

    Authors: John F Trepanowski, Mohammad M Kabir, Rick J Alleman Jr and Richard J Bloomer
    Citation: Nutrition & Metabolism 2012 9:82
  39. Protein restriction during lactation has been used as a rat model of metabolic programming to study the impact of perinatal malnutrition on adult metabolism. In contrast to protein restriction during fetal lif...

    Authors: Júlio Cezar de Oliveira, Sabrina Grassiolli, Clarice Gravena and Paulo Cezar Freitas de Mathias
    Citation: Nutrition & Metabolism 2012 9:80
  40. Dietary glycemic index or load is thought to play an important role in glucose metabolism. However, few studies have investigated the relation between glycemic index (GI) or load (GL) and glycemia in Asian pop...

    Authors: Maki Goto, Akemi Morita, Atsushi Goto, Satoshi Sasaki, Naomi Aiba, Takuro Shimbo, Yasuo Terauchi, Motohiko Miyachi, Mitsuhiko Noda and Shaw Watanabe
    Citation: Nutrition & Metabolism 2012 9:79
  41. In humans, skipping meals, especially breakfast, has been associated with obesity and other related syndromes. Recent studies in rodents suggest that fasting and feeding times are potential factors that affect...

    Authors: Chika Yoshida, Nahoko Shikata, Shinobu Seki, Naoto Koyama and Yasushi Noguchi
    Citation: Nutrition & Metabolism 2012 9:78
  42. Sirtuins are important regulators of glucose and fat metabolism, and sirtuin activation has been proposed as a therapeutic target for insulin resistance and diabetes. We have shown leucine to increase mitochon...

    Authors: Antje Bruckbauer, Michael B Zemel, Teresa Thorpe, Murthy R Akula, Alan C Stuckey, Dustin Osborne, Emily B Martin, Stephen Kennel and Jonathan S Wall
    Citation: Nutrition & Metabolism 2012 9:77

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