Table 6 Fasting serum glucose and insulin concentration, total area under the glucose (AUG) and insulin (AUI) curves, glucose disappearance ratio (K itt ) obtained from the intraperitoneal insulin tolerance test and HOMA-IR of rats maintained with the control (CC and LC) or overfeeding diets (CO and LO)
Variables | Groups | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
CC | CO | LC | LO | |||||||||
n | Mean | SEM | n | Mean | SEM | n | Mean | SEM | n | Mean | SEM | |
Basal glucose (mmol/l) | 7 | 7.0 | 0.1 | 7 | 7.1 | 0.1 | 3 | 6.8 | 0.0 | 6 | 7.0 | 0.1 |
Basal insulin (pmol/l) | 7 | 14.8b | 0.8 | 7 | 35.3a | 2.3 | 3 | 34.6 a | 1.3 | 6 | 3.3 c | 0.7 |
AUG (mmol/L. 120 min) | 7 | 2065 | 31 | 4 | 2278# | 95 | 7 | 2075 | 27 | 7 | 2183# | 52 |
AUI (pmol/L. 120 min) | 7 | 56 b | 4 | 4 | 200 a | 53 | 7 | 173 a | 44 | 7 | 78 b | 3 |
Kitt (%/min) | 8 | 0.28 b | 0.2 | 8 | 2.79 a | 0.6 | 7 | 3.05 a | 0.3 | 8 | 3.13 a | 0.4 |
HOMA-IR | 7 | 4.6 b | 0.3 | 7 | 11.1 a | 0.7 | 3 | 10.4 a | 0.4 | 6 | 1.0 c | 0.2 |
Leptin (μU/ml) | 5 | 12.1 | 1.6 | 5 | 11.8 | 1.2 | 5 | 10.8 | 0.4 | 5 | 10.2 | 0.5 |