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  1. Research

    The role of a dairy fraction rich in milk fat globule membrane in the suppression of postprandial inflammatory markers and bone turnover in obese and overweight adults: an exploratory study

    Inflammation is associated with increased bone resorption; the role of inflammation in postprandial bone turnover has not been explored. Consumption of milk fat globule membrane (MFGM) reduces inflammation in ...

    Tara S. Rogers, Elieke Demmer, Nancy Rivera, Erik R. Gertz, J. Bruce German, Jennifer T. Smilowitz, Angela M. Zivkovic and Marta D. Van Loan

    Nutrition & Metabolism 2017 14:36

    Published on: 17 May 2017

  2. Research

    Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle

    Amino acid availability stimulates protein synthesis via the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. In response to an increase in cellular amino acid availability, translocation ...

    Ted G. Graber, Michael S. Borack, Paul T. Reidy, Elena Volpi and Blake B. Rasmussen

    Nutrition & Metabolism 2017 14:35

    Published on: 11 May 2017

  3. Research

    Association of adipokines with blood pressure, arterial elasticity and cardiac markers in dialysis patients: cross-sectional analysis of baseline data from a cohort study

    Adipokines are a set of cytokines secreted by white adipose tissue that have been suggested to be involved in the development of cardiovascular diseases. We aimed to evaluate the cross-sectional associations o...

    Wenjin Liu, Lei Jiang, Jianping Chen, Chaoqing Gao, Jianmei Zhou, Jiajun Zhou, Youwei Bai, Hong Chu, Wei Fan, Liang Wang, Zhuxing Sun, Xiurong Li and Junwei Yang

    Nutrition & Metabolism 2017 14:34

    Published on: 10 May 2017

  4. Research

    Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice

    Saturated fatty acids have been shown to cause insulin resistance and low-grade chronic inflammation, whereas unsaturated fatty acids suppress inflammation via G-protein coupled receptor 120 (GPR120) in macrop...

    Hodaka Yamada, Tomio Umemoto, Masafumi Kakei, Shin-ichi Momomura, Masanobu Kawakami, San-e Ishikawa and Kazuo Hara

    Nutrition & Metabolism 2017 14:33

    Published on: 8 May 2017

  5. Research

    Oral β-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats

    Ketosis can be induced in humans and in animals by fasting or dietary interventions, such as ketogenic diets. However, the increasing interest on the ketogenic state has motivated the development of alternativ...

    Rennan de Oliveira Caminhotto, Ayumi Cristina Medeiros Komino, Flaviane de Fatima Silva, Sandra Andreotti, Rogério Antônio Laurato Sertié, Gabriela Boltes Reis and Fabio Bessa Lima

    Nutrition & Metabolism 2017 14:31

    Published on: 24 April 2017

  6. Brief communication

    Resveratrol regulates body weight in healthy and ovariectomized rats

    The elevated body weight in post-menopausal state attributes to the reduced estrogen levels which is alleviated by resveratrol (RES) but its role in control rats is not well understood. The main objective of t...

    Rupali Sharma, Neel Kamal Sharma and M. Thungapathra

    Nutrition & Metabolism 2017 14:30

    Published on: 14 April 2017

  7. Review

    The function of myostatin in the regulation of fat mass in mammals

    Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mu...

    Bing Deng, Feng Zhang, Jianghui Wen, Shengqiang Ye, Lixia Wang, Yu Yang, Ping Gong and Siwen Jiang

    Nutrition & Metabolism 2017 14:29

    Published on: 21 March 2017

  8. Research

    Dynamic and temporal assessment of human dried blood spot MS/MSALL shotgun lipidomics analysis

    Real-time and dynamic assessment of an individual’s lipid homeostatic state in blood is complicated due to the need to collect samples in a clinical environment. In the context of precision medicine and popula...

    Fei Gao, Justice McDaniel, Emily Y. Chen, Hannah E. Rockwell, Jeremy Drolet, Vivek K. Vishnudas, Vladimir Tolstikov, Rangaprasad Sarangarajan, Niven R. Narain and Michael A. Kiebish

    Nutrition & Metabolism 2017 14:28

    Published on: 20 March 2017

  9. Research

    A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?

    Vitamin D insufficiency (serum 25-OH vitamin D > 10 ng/ml and < 30 ng/ml) is prevalent in the obese (body mass index (BMI) > 30 kg/m2), yet relationships between the two are poorly understood. Objectives of this ...

    Kenneth L. Seldeen, Manhui Pang, Maria Rodríguez-Gonzalez, Mireya Hernandez, Zachary Sheridan, Ping Yu and Bruce R. Troen

    Nutrition & Metabolism 2017 14:26

    Published on: 11 March 2017

  10. Research

    Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States

    This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9–13 years.

    Kelly Virecoulon Giudici, Joseph M. Kindler, Berdine R. Martin, Emma M. Laing, George P. McCabe, Linda D. McCabe, Dorothy B. Hausman, Lígia Araújo Martini, Richard D. Lewis, Connie M. Weaver, Munro Peacock and Kathleen M. Hill Gallant

    Nutrition & Metabolism 2017 14:25

    Published on: 7 March 2017

  11. Research

    Maternal high-fat diet intensifies the metabolic response to stress in male rat offspring

    The mother’s consumption of high-fat food can affect glucose metabolism and the hypothalamic–pituitary–adrenal axis responsiveness in the offspring and potentially affect the metabolic responses to stress as w...

    Roxana Karbaschi, Homeira Zardooz, Fariba Khodagholi, Leila Dargahi, Mina Salimi and FatemehSadat Rashidi

    Nutrition & Metabolism 2017 14:20

    Published on: 28 February 2017

  12. Research

    Defective lipid metabolism associated with mutation in klf-2 and klf-3: important roles of essential dietary salts in fat storage

    Dietary salts are important factors in metabolic disorders. They are vital components of enzymes, vitamins, hormones, and signal transduction that act synergistically to regulate lipid metabolism. Our previous...

    Jun Ling, Christopher Brey, Megan Schilling, Farah Lateef, Zenaida P. Lopez-Dee, Kristopher Fernandes, Kavita Thiruchelvam, Yi Wang, Kshitij Chandel, Kai Rau, Ranjit Parhar, Futwan Al-Mohanna, Randy Gaugler and Sarwar Hashmi

    Nutrition & Metabolism 2017 14:22

    Published on: 28 February 2017

  13. Review

    Potential therapeutic targets of Guggulsterone in cancer

    Natural compounds capable of inducing apoptosis in cancer cells have always been of considerable interest as potential anti-cancer agents. Many such compounds are under screening and development with their pot...

    Ajaz A. Bhat, Kirti S. Prabhu, Shilpa Kuttikrishnan, Roopesh Krishnankutty, Jayaprakash Babu, Ramzi M. Mohammad and Shahab Uddin

    Nutrition & Metabolism 2017 14:23

    Published on: 28 February 2017

  14. Methodology

    Press-pulse: a novel therapeutic strategy for the metabolic management of cancer

    A shift from respiration to fermentation is a common metabolic hallmark of cancer cells. As a result, glucose and glutamine become the prime fuels for driving the dysregulated growth of tumors. The simultaneou...

    Thomas N. Seyfried, George Yu, Joseph C. Maroon and Dominic P. D’Agostino

    Nutrition & Metabolism 2017 14:19

    Published on: 23 February 2017

  15. Research

    Long-term intake of saccharin decreases post-absortive energy expenditure at rest and is associated to greater weight gain relative to sucrose in wistar rats

    Non-nutritive sweeteners (NNS) have been associated with increased prevalence of obesity. In previous studies, we demonstrated that saccharin could induce an increase in weight gain either when compared to suc...

    Denise Entrudo Pinto, Kelly Carraro Foletto, Ramiro Barcos Nunes, Pedro Dal Lago and Marcello Casaccia Bertoluci

    Nutrition & Metabolism 2017 14:18

    Published on: 20 February 2017

  16. Research

    Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet

    Nutritional status in early life is critically involved in the metabolic phenotype of offspring. However the changes triggered by maternal consumption of high-fat diet (HFD) in pre- or postnatal period should ...

    Laís Angélica de Paula Simino, Thaís de Fante, Marina Figueiredo Fontana, Fernanda Oliveira Borges, Márcio Alberto Torsoni, Marciane Milanski, Lício Augusto Velloso and Adriana Souza Torsoni

    Nutrition & Metabolism 2017 14:16

    Published on: 20 February 2017

  17. Research

    Impact of a 6-week non-energy-restricted ketogenic diet on physical fitness, body composition and biochemical parameters in healthy adults

    The ketogenic diet (KD) is a very low-carbohydrate, high-fat and adequate-protein diet that without limiting calories induces different metabolic adaptations, eg, increased levels of circulating ketone bodies ...

    Paul Urbain, Lena Strom, Lena Morawski, Anja Wehrle, Peter Deibert and Hartmut Bertz

    Nutrition & Metabolism 2017 14:17

    Published on: 20 February 2017

  18. Brief communication

    High-cholesterol diet does not alter gut microbiota composition in mice

    Western diet containing both saturated fat and cholesterol impairs cardio-metabolic health partly by modulating diversity and function of the microbiota. While diet containing only high fat has comparable effe...

    Lidiya G. Dimova, Nikola Zlatkov, Henkjan J. Verkade, Bernt Eric Uhlin and Uwe J. F. Tietge

    Nutrition & Metabolism 2017 14:15

    Published on: 16 February 2017

  19. Research

    Hepatic iron storage is related to body adiposity and hepatic inflammation

    Obesity has been reported to be associated with iron deficiency. However, few studies have investigated iron status in low adiposity. To investigate whether body adiposity was associated with altered hepatic i...

    Chan Yoon Park, Jayong Chung, Kyung-Ok Koo, Min Soo Kim and Sung Nim Han

    Nutrition & Metabolism 2017 14:14

    Published on: 13 February 2017

  20. Research

    Supplementation with dairy calcium and/or flaxseed fibers in conjunction with orlistat augments fecal fat excretion without altering ratings of gastrointestinal comfort

    Orlistat is a lipase inhibitor which reduced absorption of dietary fat by ~30% thereby inducing a weight loss; however, side effects occur as a consequence of increased colonic fat content. To test the hypothe...

    Mette Kristensen, Signe Rømer Juul, Karina Vejrum Sørensen, Janne Kunchel Lorenzen and Arne Astrup

    Nutrition & Metabolism 2017 14:13

    Published on: 7 February 2017

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