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  1. Research

    Positive association between musclin and insulin resistance in obesity: evidence of a human study and an animal experiment

    Musclin is a novel skeletal muscle-derived secretory factor considered to be a potent regulator of the glucose metabolism and therefore may contribute to the pathogenesis of obesity and insulin resistance (IR).

    Wen-Jia Chen, Yue Liu, Yu-Bin Sui, Hong-Tao Yang, Jin-Rui Chang, Chao-Shu Tang, Yong-Fen Qi, Jing Zhang and Xin-Hua Yin

    Nutrition & Metabolism 2017 14:46

    Published on: 10 July 2017

  2. Review

    Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside

    Diabetic patients are at an increased risk of developing heart failure when compared to their non-diabetic counter parts. Accumulative evidence suggests chronic hyperglycemia to be central in the development o...

    Phiwayinkosi V. Dludla, Elizabeth Joubert, Christo J.F. Muller, Johan Louw and Rabia Johnson

    Nutrition & Metabolism 2017 14:45

    Published on: 10 July 2017

  3. Research

    Free fatty acids and cardiovascular outcome: a Chinese cohort study on stable coronary artery disease

    Studies have revealed that plasma level of free fatty acids (FFAs) is related to cardiovascular disease. However, the role of FFAs in clinical outcomes of stable coronary artery disease (SCAD) has been less ev...

    Hui-Wen Zhang, Xi Zhao, Yuan-Lin Guo, Cheng-Gang Zhu, Na-Qiong Wu, Jing Sun, Geng Liu, Qian Dong and Jian-Jun Li

    Nutrition & Metabolism 2017 14:41

    Published on: 26 June 2017

  4. Research

    Supramolecular structure of dietary fat in early life modulates expression of markers for mitochondrial content and capacity in adipose tissue of adult mice

    Previous studies have shown that early life nutrition can modulate the development of white adipose tissue and thereby affect the risk on obesity and metabolic disease later in life. For instance, postnatal fe...

    Andrea Kodde, Eline M. van der Beek, Esther Phielix, Eefje Engels, Lidewij Schipper and Annemarie Oosting

    Nutrition & Metabolism 2017 14:37

    Published on: 12 June 2017

  5. Research

    The role of a dairy fraction rich in milk fat globule membrane in the suppression of postprandial inflammatory markers and bone turnover in obese and overweight adults: an exploratory study

    Inflammation is associated with increased bone resorption; the role of inflammation in postprandial bone turnover has not been explored. Consumption of milk fat globule membrane (MFGM) reduces inflammation in ...

    Tara S. Rogers, Elieke Demmer, Nancy Rivera, Erik R. Gertz, J. Bruce German, Jennifer T. Smilowitz, Angela M. Zivkovic and Marta D. Van Loan

    Nutrition & Metabolism 2017 14:36

    Published on: 17 May 2017

  6. Research

    Essential amino acid ingestion alters expression of genes associated with amino acid sensing, transport, and mTORC1 regulation in human skeletal muscle

    Amino acid availability stimulates protein synthesis via the mTORC1 (mechanistic target of rapamycin complex 1) signaling pathway. In response to an increase in cellular amino acid availability, translocation ...

    Ted G. Graber, Michael S. Borack, Paul T. Reidy, Elena Volpi and Blake B. Rasmussen

    Nutrition & Metabolism 2017 14:35

    Published on: 11 May 2017

  7. Research

    Association of adipokines with blood pressure, arterial elasticity and cardiac markers in dialysis patients: cross-sectional analysis of baseline data from a cohort study

    Adipokines are a set of cytokines secreted by white adipose tissue that have been suggested to be involved in the development of cardiovascular diseases. We aimed to evaluate the cross-sectional associations o...

    Wenjin Liu, Lei Jiang, Jianping Chen, Chaoqing Gao, Jianmei Zhou, Jiajun Zhou, Youwei Bai, Hong Chu, Wei Fan, Liang Wang, Zhuxing Sun, Xiurong Li and Junwei Yang

    Nutrition & Metabolism 2017 14:34

    Published on: 10 May 2017

  8. Research

    Eicosapentaenoic acid shows anti-inflammatory effect via GPR120 in 3T3-L1 adipocytes and attenuates adipose tissue inflammation in diet-induced obese mice

    Saturated fatty acids have been shown to cause insulin resistance and low-grade chronic inflammation, whereas unsaturated fatty acids suppress inflammation via G-protein coupled receptor 120 (GPR120) in macrop...

    Hodaka Yamada, Tomio Umemoto, Masafumi Kakei, Shin-ichi Momomura, Masanobu Kawakami, San-e Ishikawa and Kazuo Hara

    Nutrition & Metabolism 2017 14:33

    Published on: 8 May 2017

  9. Research

    Oral β-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats

    Ketosis can be induced in humans and in animals by fasting or dietary interventions, such as ketogenic diets. However, the increasing interest on the ketogenic state has motivated the development of alternativ...

    Rennan de Oliveira Caminhotto, Ayumi Cristina Medeiros Komino, Flaviane de Fatima Silva, Sandra Andreotti, Rogério Antônio Laurato Sertié, Gabriela Boltes Reis and Fabio Bessa Lima

    Nutrition & Metabolism 2017 14:31

    Published on: 24 April 2017

  10. Brief communication

    Resveratrol regulates body weight in healthy and ovariectomized rats

    The elevated body weight in post-menopausal state attributes to the reduced estrogen levels which is alleviated by resveratrol (RES) but its role in control rats is not well understood. The main objective of t...

    Rupali Sharma, Neel Kamal Sharma and M. Thungapathra

    Nutrition & Metabolism 2017 14:30

    Published on: 14 April 2017

  11. Review

    The function of myostatin in the regulation of fat mass in mammals

    Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mu...

    Bing Deng, Feng Zhang, Jianghui Wen, Shengqiang Ye, Lixia Wang, Yu Yang, Ping Gong and Siwen Jiang

    Nutrition & Metabolism 2017 14:29

    Published on: 21 March 2017

  12. Research

    Dynamic and temporal assessment of human dried blood spot MS/MSALL shotgun lipidomics analysis

    Real-time and dynamic assessment of an individual’s lipid homeostatic state in blood is complicated due to the need to collect samples in a clinical environment. In the context of precision medicine and popula...

    Fei Gao, Justice McDaniel, Emily Y. Chen, Hannah E. Rockwell, Jeremy Drolet, Vivek K. Vishnudas, Vladimir Tolstikov, Rangaprasad Sarangarajan, Niven R. Narain and Michael A. Kiebish

    Nutrition & Metabolism 2017 14:28

    Published on: 20 March 2017

  13. Research

    A mouse model of vitamin D insufficiency: is there a relationship between 25(OH) vitamin D levels and obesity?

    Vitamin D insufficiency (serum 25-OH vitamin D > 10 ng/ml and < 30 ng/ml) is prevalent in the obese (body mass index (BMI) > 30 kg/m2), yet relationships between the two are poorly understood. Objectives of this ...

    Kenneth L. Seldeen, Manhui Pang, Maria Rodríguez-Gonzalez, Mireya Hernandez, Zachary Sheridan, Ping Yu and Bruce R. Troen

    Nutrition & Metabolism 2017 14:26

    Published on: 11 March 2017

  14. Research

    Associations among osteocalcin, leptin and metabolic health in children ages 9–13 years in the United States

    This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9–13 years.

    Kelly Virecoulon Giudici, Joseph M. Kindler, Berdine R. Martin, Emma M. Laing, George P. McCabe, Linda D. McCabe, Dorothy B. Hausman, Lígia Araújo Martini, Richard D. Lewis, Connie M. Weaver, Munro Peacock and Kathleen M. Hill Gallant

    Nutrition & Metabolism 2017 14:25

    Published on: 7 March 2017

  15. Research

    Maternal high-fat diet intensifies the metabolic response to stress in male rat offspring

    The mother’s consumption of high-fat food can affect glucose metabolism and the hypothalamic–pituitary–adrenal axis responsiveness in the offspring and potentially affect the metabolic responses to stress as w...

    Roxana Karbaschi, Homeira Zardooz, Fariba Khodagholi, Leila Dargahi, Mina Salimi and FatemehSadat Rashidi

    Nutrition & Metabolism 2017 14:20

    Published on: 28 February 2017

  16. Research

    Defective lipid metabolism associated with mutation in klf-2 and klf-3: important roles of essential dietary salts in fat storage

    Dietary salts are important factors in metabolic disorders. They are vital components of enzymes, vitamins, hormones, and signal transduction that act synergistically to regulate lipid metabolism. Our previous...

    Jun Ling, Christopher Brey, Megan Schilling, Farah Lateef, Zenaida P. Lopez-Dee, Kristopher Fernandes, Kavita Thiruchelvam, Yi Wang, Kshitij Chandel, Kai Rau, Ranjit Parhar, Futwan Al-Mohanna, Randy Gaugler and Sarwar Hashmi

    Nutrition & Metabolism 2017 14:22

    Published on: 28 February 2017

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