Table 1 Liver RNA-seq results from WD + AF rats versus WD rats when both groups were compared to CTL rats (p < 0.01)

Functions in pancreatic islet cells to regulate glucose-stimulated insulin secretion

-2.20

-1.37

Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons

-1.93

-1.35

Main control point for the regulation of gluconeogenesis

-1.90

-1.31

Transcriptional repressor involved in organogenesis

-1.88

-1.41

Guanine nucleotide exchange factor with specificity for Rap2a and other Ras family proteins

-1.87

-1.35

Member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids.

-1.65

-1.31

Unknown function

-1.62

-1.09

Protects cells from cell death induced by actin destabilization

-1.58

-1.08

Mediates facilitated bidirectional glucose transport (a.k.a. Glut2)

-1.56

-1.22

Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins

-1.56

-1.11

Plays important roles in coordinating transcription activation and repression by Mafk

-1.52

-1.28

Unknown function

-1.51

-1.16

Membrane bound enzyme that catalyses the formation of cyclic AMP from ATP

1.55

1.32

Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport

1.61

1.55

Plays an important role in cellular zinc homeostasis as a zinc transporter

1.69

1.33

Encodes a member of the forkhead class of DNA-binding proteins, and can control the expression of liver-specific genes such as albumin

1.69

1.29

Participate in fatty acyl and cholesterol ester metabolism

1.73

1.41

Plays a specific role in immune response regulation

1.83

1.49

Inhibits transcriptional activity of Neurod1 on E-box-containing promoter

2.99

2.39