Figure 2
From: Uncoupling proteins, dietary fat and the metabolic syndrome
Insulin secretion during high fatty acid usage. (figure adapted from [6]) When FFA are elevated, such as with a high fat intake or during fasting, UCP2 expression is increased, the mitochondrial membrane potential is reduced, and fewer electrons pass through the electron transport chain resulting in reduced ATP production. The lower ATP/ADP ratio results in diminished insulin secretion.