Experiment | Participants | Dosage/Duration | Biochemistry | Performance | Body composition |
---|---|---|---|---|---|
Nissen et al. [36] | Untrained | 0, 1.5, or 3 g/day for 7 weeks | CK & 3-MH decreased, dose dependent | Greater Total weight lifted, dose dependent | Greater LBM, dose dependent |
Van Someren et al. [32, 37] | Untrained | 3 grams of HMB and .3 grams of KIC, prior to a single bout eccentric exercise | CK down | Greater 1-RM bicep curl and ROM, lower DOMS | NR |
Jowko et al. [18] | 40 M, untrained | P, 3 gram HMB, HMB &creatine, or creatine | Only HMB lowered CK, urine urea nitrogen, and plasma urea | HMB & creatine additive effect on weight lifted | HMB & creatine additive effect on LBM |
Gallagher et al. [19, 93] | 37 M, untrained | P, 38 or 76 mg/kg for 8 weeks | CK, no effect on lipid profile, immune system, or renal function | Greater Isokinetic & Isometric torque, independent of dose. | Greater LBM, no effect on FML, independent of dose |
Nissen et al. [28] | 40 M, trained and untrained | P or 3 g/day for 4 weeks | NR | Greater bench press 1-RM | Increase in LBM and FML |
Panton et al. [38] | 36 F, 39 M, varying training experiences | P or 3 g/d for 4 weeks | NR | Greater upper body strength | Greater LBM & FML. |
Thomson [39] | 34 experienced weight lifters | P or 3 g/d for 9 weeks | NR | Greater leg extension strength | NR |
Neighbors et al. [40] | Experienced collegiate football players | P or 3 g/d | NR | NR | Greater LBM and FML |
Nissen & Sharp [41] | Meta-analysis, 9 studies | P or 3 g/day | NR | .28% greater weekly strength | 1.4% greater weekly LBM |
Nissen et al. [63] | 37 F | P or 3 g/day for 4 weeks | No effect | Greater Bench Press 1-RM | Greater LBM |
Vukovich and Geri [42], Vukovich and Adams [43] | 8 experienced cyclists | 3 g/day HMB, leucine, or P, 2 weeks for each supplement. | NR | HMB increased time to reach VO2 peak, and VO2 at OBLA. | NR |
Knitter et al. [17] | 16 F & M, experienced long distance runners | P or 3 g/day prior to 20 KM run. | Lower LDH and CK. | NR | NR |
Byrd et al. [44] | 28 active M | P or 3/g HMB or creatine daily prior to downhill run | NR | HMB lowered soreness. | NR |
Vukovich et al. [29] | 31 untrained M & F | P or 3 g/day for 8 weeks | NR | Greater upper and lower body strength | Greater FML, no effect on LBM. |
Vukovich et al. [46] | 31 elderly M & F | P or 3 g/day for 8 weeks | NR | Greater Leg strength | Greater FML, trend for LBM (P > .06) |
Flakoll et al. [45] | 50 elderly F | P or 2 g of HMB, 5 g of arginine, and 1.5 g of lysine daily. | Greater protein synthesis | Greater functional mobility, leg and handgrip strength. | Trend FML (P=.08) |
Panton et al. [47] | 35 elderly M & F | P or HMB for 8 weeks | NR | Greater Functional mobility | No effect |
Soares et al. [48] | Adult mice | HMB prior to hind limb immobilization | NR | NR | Less fiber damage, greater fiber diameter. |
Cohen [51] | Dieting humans, in negative energy balance | 3 g/day of HMB | NR | NR | Greater maintenance LBM |
Coelho and Carvalho [52] | 12 elderly M | 3 g/day of HMB for 4 weeks | Lower LDL-C | Greater weight lifting strength | Greater LBM |