From: Conjugated linoleic acids as functional food: an insight into their health benefits
Biochemical action | Experimental evidence | Ref |
---|---|---|
Preadipocyte proliferation | Inhibited proliferation | [49] |
Preadipocyte differentiation | Human preadipocytes do not differentiate in the absence of a PPARγ ligand like CLA | [25] |
Fatty acid oxidation | Carnitine palmitoyltransferase activity increased by dietary CLA | |
Adipose tissue lipid synthesis | Inhibition of de novo lipogenesis through down regulation of acetyl-CoA carboxylase and fatty acid synthase | [51] |
Lipolysis | Increased lipolysis and decreased fat | [52] |
Energy expenditure | Increased oxygen consumption and energy expenditure by 10-CLA | [44] |
Stearoyl-CoA desaturase | Inhibition at protein or activity level, by post-translational modification | [15] |
Plasma leptin | Decrease in serum leptin, a hormone regulating fat level | |
Apotopsis | Induce apoptosis in adipocytes | [49] |
Tumor necrosis factor-α | Increased expression of TNFα and low fat | [54] |