Comparative effects of oleoyl-estrone and a specific β3-adrenergic agonist (CL316, 243) on the expression of genes involved in energy metabolism of rat white adipose tissue

Table 1 Weight/cell content of three main WAT sites of overweight male rats treated for 10 days with combined OE and B3A

parameter	units	control	OE	B3A	OE+B3A	P- OE	P-B3A	P-int
inguinal subcutaneous WAT weight	g	4.30 ± 0.28	3.49 ± 0.31	3.04 ± 0.56	2.87 ± 0.54	NS	0.0339	NS
epidydimal WAT weight	g	10.37 ± 0.92	8.59 ± 0.53	6.47 ± 0.61	5.05 ± 0.90	0.0481	0.0000	NS
retroperitoneal WAT weight	g	11.81 ± 1.24	8.19 ± 0.69	3.20 ± 0.64	3.26 ± 0.64	0.0408	0.0000	0.0472
combined WAT weight	g	26.48 ± 3.07	20.27 ± 1.31	12.71 ± 1.75	10.53 ± 1.39	0.0497	0.0000	NS
inguinal subcutaneous WAT cellularity	10⁶ cells	618 ± 74	549 ± 55	549 ± 29	553 ± 53	NS	NS	NS
inguinal subcutaneous WAT cell mass	ng	7.66 ± 1.24	6.83 ± 0.71	6.21 ± 0.45	4.24 ± 0.61	NS	0.0213	NS
epidydimal WAT cellularity	10⁶ cells	359 ± 45	439 ± 32	459 ± 75	385 ± 16	NS	NS	0.0039
epidydimal WAT cell mass	ng	24.9 ± 1.3	22.4 ± 1.9	12.9 ± 1.1	12.5 ± 0.8	NS	0.0000	NS
retroperitoneal WAT cellularity	10⁶ cells	431 ± 70	340 ± 69	372 ± 11	377 ± 73	NS	NS	NS
retroperitoneal WAT cell mass	ng	28.1 ± 1.8	29.0 ± 6.0	7.54 ± 0.33	8.29 ± 0.90	NS	0.0000	NS

The values are the mean ± sem of 6 different animals. Statistical significance of the diferences (2-way ANOVA): P-OE/PB3A represents the P values for OE/B3A inducing a significant effect on the given parameter; P-int indicates the significance of the interaction between both agonists. NS = p > 0.05.

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