Figure 1
From: Vaticanol C, a resveratrol tetramer, activates PPARα and PPARβ/δ in vitro and in vivo
Activation of PPARs by Resveratrol, ε-Viniferin and Vaticanol C. (A) Structures of resveratrol (monomer), ε-viniferin (dimer) and vaticanol C (tetramer). (B) Activation of PPARα, β/δ, and γ was evaluated by transfection assays using BAEC with PPRE-luc together with GS-hPPARα, pCMX-NUC1 or pCMX-hPPARγ1, respectively. Results are presented as relative luciferase activities obtained by dividing the normalized luciferase activity from the reporter vector PPRE-luc. *, P < 0.05, **, P < 0.01 compared with the value of cells treated with ethanol (control) by unpaired t-test (n = 3).