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Table 2 Profile of the thyroid function and thyroid autoantibodies of premenopausal female patients with Graves' disease compared to both healthy controls and patients with Hashimoto's thyroiditis on stable levothyroxine replacement.

From: Can bone loss be reversed by antithyroid drug therapy in premenopausal women with Graves' disease?

 

Controls

Graves' disease Months after diagnosis

Hashimoto's thyroiditis

Study points (months)

 

Baseline

3

18 ± 3

36 ± 3

 

Number

19

32

18

TSH (mU/L)

1.5

< 0.01##

0.2**

1.1**

0.6**

1.2NS

 

(1.3-1.7)

(< 0,01-0.02)

(0.1-0.5)

(0.8-1.9)

(0.4-1.0)

(0.4-3.7)

T4 (nmol/L)

91

246##

93**

98**

103**

105 NS

 

(84-98)

(231-263)

(76-115)

(91-105)

(92-115)

(92-120)

fT4 (pmol/L)

14

51##

15**

14**

15**

16 NS

 

(14-15)

(45-56)

(13-18)

(13-15)

(14-16)

(14-18)

T3 (nmol/L)

1.5

5.4##

1.8**

1.5**

1.5**

1.6 NS

 

(1.3-1.7)

(4.6-6.3)

(1.5-2.2)

(1.4-1.7)

(1.3-1.7)

(1.5-1.8)

fT3 (pmol/L)

5.2

24##

5.8**

4.6**

4.2**

5.7 NS

 

(4.7-5.8)

(19-30)

(4.6-7.2)

(4.3-4.9)

(3.8-4.8)

(4.9-6.7)

TRAb (< 1.0

< 1.0

7.3##

4.1**

2.0**

1.2**

< 1.0

IU/L)

 

(4.9-10.8)

(2.6-6.2)

(1.3-2.9)

(0.8-1.8)

 

Anti-TPO

< 60

292##

206NS

174*

249NS

1452##

(< 60 IU/L)

 

(166-513)

(121-349)

(107-282)

(143-435)

(785-2686)

  1. Data are expressed as antilog mean (CI 95%) and significance is marked as * = p < 0.05, ** = p < 0.005 when compared to baseline and marked differently as # = p < 0.05, ## = p < 0.005 when normal controls are compared to baseline data for patients with Graves' disease or patients with Hashimoto's disease. NS = non-significant.