Figure 3

Histopathological findings in hepatic tumors stained with HE: (A, B) HE-stained section of a normal hepatic organ in the negative control group (10× and 40×); (C, D) HE-stained section of a hyperplasia in the high dose group (10× and 40×); (E, F) HE-stained section of a fibrosis (10× and 40×) in the middle dose group; (G, H) HE-stained section of a moderately differentiated hepatocellular carcinoma in the positive control group (10× and 40×). The neoplastic cells are large, oval- or irregular-shaped, and their cytoplasm is abundant. The nuclei are enlarged, binucleated and pleomorphic nuclei with granular chromatin. Sometimes large basophilic hyperchromatic nuclei are also noticed. The cytoplasm is loose and irregularly extensive vacuolated with masses of acidophilic materials, although this was not invariable.