Figure 6From: The biology of lysine acetylation integrates transcriptional programming and metabolismAn integrated view of the metabolic processes (fatty acid biosynthesis, glycolysis, gluconeogenesis and amino acid metabolism) that converge on the citric acid cycle. Red stars represent lysine-acetylated metabolic enzymes and the red box highlights the critical metabolic products integrated into various metabolic pathways. Highlighted enzymes with their respective EC numbers are: pyruvate dehydrogenase (EC 1.2.4.1), dihydrolipoyl dehydrogenase (EC 1.8.1.4), pyruvate carboxylase (EC 6.4.1.1), malate dehydrogenase (EC 1.1.1.37), fumarate hydratase (EC 4.2.1.2), citrate (Si)-synthase (EC 2.3.3.1), ATP citrate synthase (EC 2.3.3.8), aconitate hydratase (EC 4.2.1.3), isocitrate dehydrogenase (NADP+) (1.1.1.42), isocitrate dehydrogenase (NAD+) (1.1.1.41), succinate dehydrogenase (1.3.5.1), succinate--CoA ligase (6.2.1.4; GDP forming), and succinate--CoA ligase (6.2.1.5; ADP forming).Back to article page