Low-calcium diet prevents fructose-induced hyperinsulinemia and ameliorates the response to glucose load in rats

Nutrition & Metabolism

Table 2 Fasting plasma levels of calcium, insulin, glucose and triglycerides (TG) on various days after introduction of experimental diets

	AIN125	FRU125	AIN25	FRU25
Ca²⁺, mg/dL^***
Day 10	5.60 ± 0.08	5.68 ± 0.08	5.36 ± 0.08	5.28 ± 0.04
Day 17	5.52 ± 0.08	5.60 ± 0.08	5.28 ± 0.08	5.28 ± 0.08
Insulin, ng/mL^**§
Day 11	2.0 ± 0.3	2.6 ± 0.3	1.9 ± 0.3	1.9 ± 0.3
Day 18	2.4 ± 0.3	3.3 ± 0.3	2.2 ± 0.3	2.3 ± 0.3
Day 42	4.7 ± 0.5	5.8 ± 0.4	4.0 ± 0.5	4.4 ± 0.5
Glucose, mg/dL^#§
Day 11	101 ± 4	109 ± 4	97 ± 4	105 ± 4
Day 18	115 ± 1	126 ± 4	116 ± 4	123 ± 4
Day 42	134 ± 3	143 ± 3	129 ± 3	138 ± 3
TG, mg/dL^#§
Day 11	56 ± 15	134 ± 16	48 ± 15	102 ± 14
Day 18	82 ± 16	173 ± 17	61 ± 16	163 ± 15
Day 42	98 ± 18	201 ± 19	75 ± 18	153 ± 16

Data are presented as mean ± SEM of n = 14–18 per group. Blood samples were collected during the light period, after a 5–6 h fast except for the calcium measurements when rats were in a fed state. ** - main effect of Dietary Calcium p < 0.01; ***-main effect of Dietary Calcium p < 0.001; #-main effect of Diet Carbohydrate p < 0.001; §-main effect of Time p < 0.001, Day11 < Day18 < Day42

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