Gene symbol/GenBank accession/Gene ID | Entrez gene name | HFrD/Chow (Fold-change) | HFrD-NDGA/HFrD (Fold-change) |
---|---|---|---|
 | Fatty Acid Transport |  |  |
Slc27a1 Acc: NM_053580.2 ID: 94172 | Soluble carrier family 27 (fatty acid transporter), member 1 (FATP1) | 0.626371↓ (p = 0.000005) | 1.243585↑ (p = 0.035818) |
Slc27a2 Acc: NM_031736.1 ID: 65192 | Soluble carrier family 27 (fatty acid transporter), member 2 (FATP2) | ─ | 0.843521 (p = 0.704995) |
 | Acyl-CoA Synthetases |  |  |
Acsl1 Acc: NM_012820.1 ID: 25288 | Acyl-CoA synthetase long-chain family member 1 (ACS, Acas, COAA, Facl2) | 0.871766 (p = 0.143945) | 1.022277 (p = 0.780026) |
Acsl4 Acc: NM_053623.1 ID: 113976 | Acyl-CoA synthetase long-chain family member 4 (ACS4, Facl4) | 0.878305 (p = 0.54153) | 0.964436 (p = 0.62090) |
Acsm3 Acc: NM_033231.1 ID: 24763 | Acyl-CoA synthetase medium-chain family member 3 (Sa, Sah) | 0.987186 (p = 0.961215) | 0.805024 (p = 0.413656) |
Acss2 Acc: NM_001107793.1 ID: 311569 | Acyl-CoA synthetase short chain family member 2 (Acss2) | 0.966705 (p = 0.717211) | 0.884133 (p = 0.161879) |
 | Fatty Acid Oxidation |  |  |
Cpt1a Acc: NM_031559.2 ID: 25757 | Carnitine palmitoyltransferase 1a, liver (CPT-1a) | 0.929886 (p = 0.346192) | 0.971389 (p = 0.737175) |
Cpt1b Acc: NM_013200.1 ID: 25756 | Carnitine palmitoyltransferase 1b, muscle (CPT-1B, M-CPT1) | 0.705154↓ (p = 0.000182) | 1.080327 (p = 0.411449) |
Cpt1c Acc: NM_001034925.2 ID: 308579 | Carnitine palmitoyltransferase 1c (CPT 1C, CPT1-B, CPTI-B) | 0.912484 (p = 0.292825) | 1.076052 (p = 0.61451) |
Cpt2 Acc: NM_012930.1 ID: 25413 | Carnitine palmitoyltransferase 2 (CPTII) | 1.058655 (p = 0.394189) | 1.03461 (p = 0.630057) |
Acox1 Acc: NM_017340.2 ID: 506811 | Acyl-CoA oxidase, palmitoyl (RATACOA1) | 1.291301↑ (p = 0.000954) | 1.086216 (p = 0.293942) |
Acadl Acc: NM_012819.1 ID: 25287 | Acyl-CoA dehydrogenase, long chain (ACOADA, LCAD) | 1.024278 (p = 0.778232) | 0.976708 (p = 0.800795) |
Acadm Acc: NM_016986.2 ID: 24158 | Acyl-CoA dehydrogenase, C-4 to C-12 straight chain (MCAD) | 1.017514 (p = 0.84005) | 0.917314 (p = 0.340538) |
Acads Acc: NM_022512.1 ID: 64304 | Acyl-Coa dehydrogenase, C-2 to C-3 short chain (Scad) | 0.645793↓ (p = 0.000149) | 1.280965 (p = 0.065028) |
Acadsb Acc: NM_013084.1 ID: 25618 | Acyl-CoA dehydrogenase, short/branched chain | 0.775064 (p = 0.065038) | 1.804414↑ (p = 0.00009) |
Acadvl Acc: NM_012891.1 ID: 25363 | Acyl-CoA dehydrogenase very long chain (VLCAD) | 0.785093↓ (p = 0.006311) | 1.285064↑ (p = 0.003725) |
Eci1 Acc: NM_017306.4 ID: 29740 | Enoyl-CoA delta isomerase 1(Deci) | 0.978982 (p = 0.785245) | 1.134394 (p = 0.11201) |
Echs1 Acc: NM_078623.2 ID: 140547 | Enoy-CoA hydratase, short chain 1, mitochondrial | 0.764837↓ (p = 0.007566) | 1.220593 (p = 0.080591) |
Ehhadh Acc: NM_133606.1 ID: 171142 | Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase | 0.64736↓ (p = 0.000141) | 1.219944 (p = 0.061876) |
Eci2 Acc: NM_001006966.1 ID:291075 | Enoyl-CoA delta isomerase 2 (Peci) | 0.899414 (p = 0.120824) | 0.74287↓ (p = 0.000344) |
 | Fatty Acid Synthesis/ De Novo |  |  |
 | Lipogenesis |  |  |
Gckr Acc: NM_013120.2 ID: 25658 | Glucokinase (hexokinase 4) regulator (GLRE) | 0.755501 (p = 0.055196) | 1.126918 (p = 0.490323) |
Gck Acc: NM_012565.1 ID: 24385 | Glukokinase (GLUKA, RNGK2) | 4.265985↑ (p = 6.89E-18) | 0.302628↓ (p = 4.47E-11) |
Pklr Acc: NM_012624.3 ID: 24651 | Pyruvate kinase, liver and RBC (PK1, PKL, Pklg) | 2.097495↑ (p = 0.000451) | 0.498737↓ (p = 0.000675) |
Acly Acc: NM_016987.2 NM_001111095.1 ID: 24159 | ATP citrate lyase (ACL, Clatp) | 1.295435↑ (p = 0.000403) | 0.895746 (p = 0.143597) |
Fasn Acc: NM_01332.1 ID: 50761 | Fatty acid synthase | 1.08142 (p = 0.423101) | 0.904824 (p = 0.357733) |
Me1 Acc: NM_012600.2 ID: 24552 | Malic enzyme 1, NADP(+)-dependent, cytosolic (MOD1) | 0.847973 (p = 0.065373) | 0.990152 (p = 0.920281) |
Me2 Acc: NM_001111095.1 ID: 307270 | Malic enzyme 2, NAD(+)-dependent, mitochondrial | — | — |
Scd1 Acc: NM_139192.2 ID: 246074 | Stearyol-Coenzyme A desaturase 1 | 9.92997↑ (p = 0.00E + 00) | 0.367553↓ (p = 3.10E-28) |
Elovl1 Acc: NM_001044275.1 ID: 67953.2 | ELOVL fatty acid elongase 1 | 0.696973↓ (p = 0.) and 1.025883 (p = 0.77018) | 1.502326↑ (p = 5.63E-09) and 1.199776 (p = 0.056696) |
Elovl2 Acc: NM_001109118.1 ID: 498728 | ELOVL fatty acid elongase 2 | 0.712072 (p = 0.389679) | 0.330644 (p = 0.176175) |
Elovl4 Acc: NM_001191796.1 XM_001062735.2 ID: 315851 | ELOVL fatty acid elongase 4 | 1.053677 (p = 0.719414) | 0.950803 (p = 0.678269) |
Elovl5 Acc: NM_134382.1 ID: 171400 | ELOVL fatty acid elongase 5 (rELO1) | 1.027579 (p = 0.719414) | 2.101966↑ (p = 1.14E-17) |
Elovl6 Acc: NM_134383.2 ID: 171402 | ELOVL fatty acid elongase 6 (Lce2, rELO2) | 0.511033↓ (p = 2.11E-11) and 1.322709↑ (p = 0.037357) | 1.436011↑ (p = 0.001273) and 0.797587 (p = 0.0795) |
Fads1 Acc: NM_053445.2 ID: 84575 | Fatty acid desaturase 1 | 1.16415 (p = 0.102452) | 0.828712↓ (p = 0.042428) |
Fads2 Acc: NM_031344.2 ID: 83512 | Fatty acid desaturase 2 (Fadsd6) | 1.036468 (p = 0.84278) | 0.890867 (p = 0.485008) |
Mlcyd Acc: NM_053477.1 ID: 85239 | Malonyl-CoA decarboxylase | 1.06015 (p = 0.581558) | 0.800024↓ (p = 0.047506) |
 | Triglyceride (TG) Synthesis/VLDL-TG Assembly |  |  |
Agpat1 Acc: NM_212458.1 ID: 406165 | 1-Acylglycerol-3-phosphate O-acyltransferase 1 | 1.733174↑ (p = 0.000011) | 0.551598↓ (p = 0.000015) |
Agpat2 Acc: NM_001107821.1 ID: 311821 | 1-Acylglycerol-3-phosphate O-acyltransferase 2 | 0.890825 (p = 0.154834) | 0.98959 (p = 0.895733) |
Agpat3 Acc: NM_001106378.1 ID: 311821 | 1-Acylglycerol-3-phosphate O-acyltransferase 3 | 0.625706↓ (p = 0.004796) | 1.138055 (p = 0.352178) |
Agpat6 Acc: NM_001047849.1 ID: 305166 | 1-Acylglycerol-3-phosphate O-acyltransferase 6 (RGD1310520) | 0.668305↓ (p = 0.754188) | 1.483745↑ (p = 0.000001) |
Agpat9 Acc: 001025670.1 ID: 305166 | 1-Acylglycerol-3-phosphate O-acyltransferase 9 | 0.702126↓ (p = 0.007365) | 1.461539↑ (p = 0.002906) |
Mogat1 Acc: NM_001108803.1 ID: 363261 | Monoacylglycerol O-acyltransferase 1 | 0.911577 (p = 0.405954) | 0.977825 (p = 0.860977) |
Dgat1 Acc: NM_053437.1 ID: 84497 | Diacylglycerol O-acyltransferase 1 (ARAT, Dgat) | 0.766526↓ (p = 0.033377) | 1.35964↑ (p = 0.012554) |
Dgat2 Acc: NM_001012345.1 ID: 252900 | Diacylglycerol O-acyltransferase 2 (ARAT) | 1.000764 (p = 0.992838) | 0.890682 (p = 0.159626) |
Arf3 Acc: NM_080904.2 ID: 140940 | ADP-ribosylation factor 3 (AC1-253) | 1.253088↑ (p = 0.000991) | 0.745999↓ (p = 0.000289) |
 | Cholesterol Synthesis/Metabolism |  |  |
Acat2 Acc: NM_001006995.1 ID: 308100 | Acetyl-CoA acetyltransferase 2 (Acat3, Ab2-076) | 1.149942 (p = 0.064026) | 0.846982↓ (p = 0.020354) |
Hmgcr Acc: NM_013134.2 ID: 25675 | 3-Hydroxy-3-methylglutaryl-CoA reductase (3H3M) | 0.614003↓ (p = 0.000734) | 1.212062 (p = 0.155741) |
Insig 1 Acc: NM_022392.1 ID: 64194 | Insulin induced gene 1 | 1.046145 (p = 0.573908) | 0.618888↓ (p = 0.000006) |
Insig 2 Acc: NM_178091.4 ID: 288985 | Insulin induced gene 2 | 0.823541 (p = 0.133816) | 1.467193↑ (p = 0.003866) |
Ldlr Acc: NM_175762.2 ID: 300438 | Low density lipoprotein receptor (LDLRA) | 0.761982 (p = 0.148211) | 1.204468 (p = 0.362466) |
Mvk Acc: NM_031063.1 ID: 81727 | Mevalonate kinase (Lrbp) | 1.024571 (p = 0.839357) | 1.168772 (p = 0.150024) |
Npc1 Acc: NM_001002025.11 ID: 266732 | Niemann-Pick disease, type C1 (Cdig2) | 0.838672 (p = 0.861612) | 1.21535 (p = 0.847542) |
 | Proteins Involved in Lipid Clearance |  |  |
Abca4 Acc: NM_00110772.1 ID: 310836 | ATP-binding cassette, subfamily A (ABC1), member 4 (ABCR) | ─ | ─ |
Abcb4 Acc: NM_012690.1 ID: 24891 | ATP-binding cassette, subfamily B (MDR/TAP), member 4 (Mdr2, Pgy3) | 1.290231 (p = 0.284859) | 0.894225 (p = 0.438512) |
Abcb11 Acc: NM_031760.1 ID: 83569 | ATP-binding cassette, subfamily B (MDR/TAP), member 11 (Bsep, Spgp) | 0.693218 (p = 0.05412) | 1.397109 (p = 0.086006) |
Abcc3 Acc: NM_080581.1 ID: 140668 | ATP-binding cassette, subfamily C (CFTR/MRP), member 3 (Mlp2, Mrp3) | 0.930144 (p = 0.499966) | 0.930223 (p = 0.509623) |
Abcc6 Acc: NM_031013.1 ID: 81642 | ATP-binding cassette, subfamily C (CFTR/MRP), member 6 (Mrp6) | 1.044104 (p = 0.931493) | 0.953551 (p = 0.836794) |
Abcd1 Acc: NM_001108821.1 ID: 363516 | ATP-binding cassette, subfamily D (ALD), member 3 (RGD1562128) | 0.981591 (p = 0.867544) | 0.973671 (p = 0.807543) |
Abcd3 Acc: NM_012804.1 ID: 25270 | ATP-binging cassette, subfamily D (ALD), member 3 (PMP70, Pxmp1) | 0.775986↓ (p = 0.000407) | 1.067058 (p = 0.3708) |
Abcg2 Acc: NM_181381.2 ID: 312382 | ATP-binding cassette, subfamily G (WHITE), member 2 (BCRP1) | 0.840673 (p = 0.694657) | 1.966469 (p = 0.051575) |
Abcg5 Acc: NM_053754.2 ID: 114628 | ATP-binding cassette, subfamily G (WHITE), member 5 | 1.289574 (p = 0.31897) | 0.839246 (p = 0.375668) |
Apoa4 Acc: NM_012737.1 ID: 25080 | Apolipoprotein A-IV (Apo-AIV, ApoA-IV, ApoAIV) | 1.975251↑ (p = 0.005407) | 0.701419 (p = 0.119689) |
Apob Acc: NM_019287.2 ID: 54225 | Apolipoprotein B (Aa1064, AC1-060, Apo B-100, ApoB-100, ApoB-48) | 0.90111 (p = 0.750761) | 1.187596 (p = 0.618021) |
Apoc2 Acc: NM_001085352.1 ID: 292697 | Apolipoprotein C-II (RGD1560725) | 2.057009↑ (p = 0.000592) | 0.532413↓ (p = 0.000001) |
Apoc3 Acc: NM_012501.1 ID: 24207 | Apolipoprotein C-III (ApoC-III, apo-CIII) | 0.684698↓ (p = 0.000263) | 1.307856↑ (p = 0.008469) |
Apoe Acc: NM_138828.2 ID: 25728 | Apolipoprotein E (APOEA) | 1.485673↑ (p = 0.000003) | 0.778654↓ (p = 0.004399) |
Apof Acc: NM_001024351.1 ID: 500761 | Apolipoprotein F | ─ | ─ |
Lpl Acc: NM_012498.2 ID: 24539 | Lipoprotein lipase | 1.135422 (p = 0.100839) | 0.812916↓ (p = 0.007915) |
Vldlr Acc: NM_013155.2 ID: 25696 | Very low density lipoprotein receptor | 0.6722↓ (p = 0.000001) Or 0.486999↓ (p = 8.10E-08) | 1.096751 (p = 0.283284) Or 1.520316↑ (p = 0.002103) |
Ppt1 Acc: NM_022502.2 ID: 29411 | Palmitoyl-protein thioesterase 1 (Ppt) | 0.9252 (p = 0.307699) | 1.076592 (p = 0.320819) (p = 0.192733) |
 | Central Metabolic Regulators (Lipid Transcription Factors) |  |  |
Foxa1 Acc: NM_012742.1 ID: 25098 | Forkhead box A1 | 0.828962 (p = 0.418498) | 1.067287 (p = 0.72547) |
Hnf4a Acc: NM_022180.1 ID: 25735 | Hepatocyte nuclear factor 4, alpha (Hnf4alpha, Hnf4a) | 1.208695 (p = 0.660749) | 0.934321 (p = 0.806661) |
Mlxipl Acc: NM_133552.1 ID: 171078 | MLX interacting protein-like (ChREBP, WS-bHLH, Wbscr14, bHLHd14) | 1.019326 (p = 0.831873) | 1.23554↑ (p = 0.015243) |
Nr1h3 Acc: NM_031627.2 ID: 58852 | Nuclear receptor subfamily 1, group H, member 3 (LXRalpha) | 0.898224 (p = 0.132662) | 1.22274↑ (p = 0.00316) |
Ppara Acc: NM_013196.1 ID: 25747 | Peroxisome proliferator activated receptor alpha (PPAR) | 1.042152 (p = 0.702728) | 1.34318↑ (p = 0.01657) |
Ppard Acc: NM_013141.2 ID: 25682 | Peroxisome proliferator activated receptor delta (Pparb) | 1.049635 (p = 0.640966) and 1.023475 (p = 0.858495) | 1.001442 (p = 0.988966) and 0.929482 (p = 0.61664) |
Pparg Acc: NM_013124.3 NM_001145366.1 NM_001145367.1 ID: 25664 | Peroxisome proliferator activated receptor gamma | 1.140175 (p = 0.07102) | 0.96347 (p = 0.648174) |
Ppargc1a Acc: NM_031347.1 ID: 83516 | Peroxisome proliferator activated receptor gamma, coactivator 1 alpha (Ppargc1) | 2.166136↑ (p = 0.013221) | 0.49897 (p = 0.089406) |
Ppargc1b Acc: NM_176075.2 ID: 291567 | Peroxisome proliferator activated receptor, coactivator 1 beta (PGC1beta, Perc) | 0.787663↓ (p = 0.007863) | 1.092996 (p = 0.296335) |
Srebf1 Acc: XM_213329.5 XM_001075680.2 ID: 78968 | Sterol regulatory element binding transcription factor 1 (ADD-1, ADD1, SREBP-1, SREBP-1c, Srebp1) | 0.810661↓ (p = 0.012341) and 0.885992 (p = 0.449261) | 1.17608 (p = 0.063087) and 1.460992↑ (p = 0.011985) |
Srebf2 Acc: NM_001033694.1 ID: 300095 | Sterol regulatory element binding transcription factor 2 (SREBP-2, SREBP2-retired, Srebf2) | 0.854579 (p = 0.062966) | 0.964258 (p = 0.651328) |
Xbp1 Acc: NM_001004210.1 ID: 289754 | X-box binding protein 1 (HTF) | 1.168979 (p = 0.087563) | 1.080755 (p = 0.380509) |