Wt ND | Wt HFD | Epac1−/− ND | Epac1−/− HFD | Epac2−/− ND | Epac2−/− HFD | |
---|---|---|---|---|---|---|
N | 8 | 16 | 6 | 6 | 6 | 10 |
BW (g) | 27.5 ± 1.6 | 44.5 ± 2.0& | 24.2 ± 0.5 | 48.4 ± 1.1& | 24.7 ± 0.6 | 38.8 ± 3.0& |
HW (mg) | 146.3 ± 8.2¤ | 162.2 ± 6.7¤ | 154.3 ± 8.6¤ | 197.7 ± 6.0& | 126.5 ± 7.2¤ | 137.4 ± 5.3¤ |
HW/BW (mg/g) | 5.3 ± 0.2€ | 3.7 ± 0.2& | 6.4 ± 0.4 | 4.1 ± 0.2& | 5.2 ± 0.3€ | 3.6 ± 0.2 & |
LV volume (mm3) | 108.6 ± 6.7 | 117.5 ± 5.2 | 96.8 ± 4.8 | 124.7 ± 8.8 | 96.0 ± 5.4 | 104.9 ± 2.7 |
Total fat (g) | 1.7 ± 0.3 | 7.7 ± 0.5& | 1.2 ± 0.1 | 8.6 ± 0.4& | 1.1 ± 0.1 | 6.9 ± 0.7&¤ |
iWAT (g) | 0.4 ± 0.1 | 2.0 ± 0.1& | 0.3 ± 0.1 | 1.8 ± 0.1& | 0.4 ± 0.1 | 1.9 ± 0.2& |
rWAT (g) | 0.5 ± 0.1 | 2.1 ± 0.2& | 0.3 ± 0.1 | 2.5 ± 0.2& | 0.3 ± 0.1 | 2.0 ± 0.2& |
gWAT (g) | 0.8 ± 0.2 | 3.6 ± 0.3& | 0.6 ± 0.1 | 4.3 ± 0.2& | 0.5 ± 0.1 | 3.0 ± 0.3&¤ |
rWAT + gWAT (g) | 1.3 ± 0.2 | 5.7 ± 0.4& | 0.9 ± 0.1 | 6.8 ± 0.3& | 0.8 ± 0.1 | 5.1 ± 0.5&¤ |
Visceral fat (% of BW) | 4.6 ± 0.8 | 12.5 ± 0.5& | 3.4 ± 0.5 | 14.1 ± 0.4& | 3.4 ± 0.2 | 12.1 ± 0.7& |
Body fat (% of BW) | 6.1 ± 1.0 | 17.0 ± 0.5& | 4.7 ± 0.4 | 17.8 ± 0.5& | 4.6 ± 0.4 | 16.7 ± 1.0&¤ |