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Fig. 5 | Nutrition & Metabolism

Fig. 5

From: Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet

Fig. 5

Metabolic programming and hepatic miRNAs modulation by maternal HFD consumption persists into adult life of offspring. Body weight (a), adiposity (b), caloric intake (c), fasting glucose (d), mRNA levels (qRT-PCR) of hepatic Cpt1a and Acadvl (e) and Agpat and Gpam (f), serum lipids (CHOL and TAG - g), total hepatic lipid content (h), microRNA level (qRT-PCR) of hepatic miR-122 and miR-370 (i) from adult offspring from CC and HH groups at d82. For relative gene expression analysis, β-Actin and U6snRNA were used as endogenous controls. Values are means (n = 5–8) + - SEM. Student's t-test was used in all analyses to compare CC and HH groups. Different letters indicate statistical significance between groups (p ≤ 0.05)

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Nutrition & Metabolism

ISSN: 1743-7075

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