Fig. 1

Amino Acid Transporters. SLC38A10 and SLC38A9 are both sodium-coupled neutral amino acid transporters, with SLC38A9 implicated in activating RAGULATOR and hence mTORC1 and SLC38A10 having an unknown function. SLC7A1 is a cationic transporter (e.g., arginine) and SLC7A8 codes for the LAT2 light subunit. x-axis: EAA = essential amino acid only group, CQ = essential amino acid plus chloroquine group, mean = mean of group ± standard error; y-axis units is fold change in gene expression from the basal to fed state using the 2-∆∆Ct method; bar indicates independent t-test comparison between EAA and CQ, symbols over means indicate paired t-test comparison of fold change with normalized baseline; * = p ≤ 0.05, ** = p ≤ 0.01, # = p < 0.10, NSD or no label = p > 0.10; the female subjects (n = 3 in CQ) are delineated by darker data points