Fig. 4

RAGE, Sirt1, NF-κB p65 and DDOST (AGER1) changes in the colon. a RAGE, b Sirt1, c AGER1 (DDOST), d Representative immunoblotting bands (performed in triplicate) and e–g quantification of RAGE, Sirt1 and NF-κB p65 protiens. HE: herbal extract; ND: normal diet; HFD: high AGEs-fat diet; HD: high dose; DSS: 2.5% dextran sulphate sodium; AGEs: Advanced glycation end products; AGER1: Advanced glycation end products receptor 1; DDOST: dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit; NF-κB: nuclear transcription factor kappa B; RAGE: advanced glycation end products receptor. Data as mean with 95% CI, n = 6 per group. * and ** respectively represents p < 0.05 and p < 0.01 (significant difference between the groups)