Association between hypertension and coffee drinking based on CYP1A2 rs762551 single nucleotide polymorphism in Taiwanese

Table 4 Multiple logistic regression model showing the dose–response association between coffee drinking and hypertension grouped into the rs762551 genotypes

Variables	rs762551 AA			rs762551 AC + CC
Variables	OR	95% CI	p-value	OR	95% CI	p-value
Coffee drinking (Reference: no coffee drinking)
< 1800 ml/week	1.029	0.879–1.205	0.7232	0.856	0.745–0.983	0.0278
≥ 1800 ml/week	0.916	0.776–1.081	0.2977	0.755	0.654–0.872	0.0001
Trend test			0.4037			< 0.0001
Tea drinking (Reference: No)
Yes	0.937	0.810–1.084	0.3817	1.025	0.905–1.161	0.6934
Sex (Reference: Women)
Men	1.256	1.078–1.465	0.0035	1.224	1.073–1.396	0.0026
Age	1.096	1.087–1.105	< 0.0001	1.091	1.084–1.099	< 0.0001
BMI (Reference: Normal)
Underweight	0.285	0.131–0.616	0.0014	0.182	0.085–0.390	< 0.0001
Overweight	1.906	1.642–2.212	< 0.0001	2.101	1.847–2.390	< 0.0001
Obesity	4.317	3.681–5.062	< 0.0001	4.537	3.963–5.195	< 0.0001
Cigarette smoking (Reference: Never)
Former	1.191	0.972–1.459	0.0921	1.137	0.955–1.354	0.1488
Current	0.880	0.672–1.151	0.3512	1.126	0.897–1.415	0.3059
Alcohol drinking (Reference: Never)
Former	1.528	1.153–2.027	0.0032	1.492	1.177–1.891	0.0009
Current	1.480	1.160–1.888	0.0016	1.284	1.041–1.585	0.0197
Exercise(Reference: No)
Yes	1.008	0.885–1.148	0.9073	1.051	0.939–1.177	0.3854

ISSN: 1743-7075