Fig. 5
From: PA and OA induce abnormal glucose metabolism by inhibiting KLF15 in adipocytes
PA inhibits KLF15 expression through GPR120/P-p38 MAPK, resulting in abnormal glucose metabolism of 3T3-L1 adipocytes. AH7614, GW1100 and SB203580 were respectively added into 1500 μM PA treated cells to block GPR120, GPR40 and p38 MAPK. The mRNA (A) and protein B–D levels of P-p38 MAPK, KLF15 and glucose consumption E were detected. Pattern diagram F were presented. Results represent mean ± SEM. One-way ANOVA, *P < 0.05, ***P < 0.001 versus the control group, #P < 0.05, ##P < 0.05, ###P < 0.001 versus the PA-treated group, difference was statistically significant