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Table 1 Estimates of clinical parameters of MHO/MUO following the IDF definition of metabolic syndrome

From: Long-term impact of the metabolic status on weight loss-induced health benefits

 

Metabolically Healthy Obese (MHO)

Metabolically Unhealthy Obese (MUO)

p-value (MHO vs MUO)

T-3

T0

T12

T18

T-3

T0

T12

T18

T-3 → T0

T-3 → T12

T-3 → T18

n: m/w

59: 9/50

59: 9/50

46: 7/39

44: 6/38

84: 22/62

84: 22/62

75: 19/56

68: 19/49

   

Randomization: control/intervention

29/30

   

42/42

      

Age [years]

48.6 [45.2,52.0]

   

51.9 [49.2,54.5]

      

BMI [kg/m2]

36.0 [34.2,37.7]

31.4 [29.7,33.1]***

32.5 [30.8,34.3]***

33.5 [31.7,35.2]***

38.2 [36.8,39.6]

33.5 [32.1,34.9]***

34.1 [32.7,35.6]***

35.2 [33.8,36.6]***

1

1

1

Waist circumference [cm]

107.6 [104.2,110.9]

99.4 [96,102.7]***

100.9 [97.5,104.4]***

101 [97.5,104.5]***

114 [111.3,116.8]

103.8 [101.1,106.5]***

104.4 [101.6,107.2]***

106 [103.2,108.8]***

0.6

0.14

1

Serum glucose [mg/dl]

82.4 [78.8,86]

80.8 [77.2,84.4]

84.3 [80.4,88.2]

86.9 [83.0,90.9]

95.0 [92.0,97.9]

86.1 [83.1,89.0]***

89.7 [86.6,92.8]**

93.2 [90.1,96.3]

0.01

0.02

0.06

HbA1c [%]

5.5 [5.3,5.7]

5.9 [5.7,6]**

5.4 [5.2,5.6]

5.5 [5.3,5.7]

5.9 [5.8,6.1]

5.9 [5.8,6.1]

5.6 [5.4,5.8]***

5.7 [5.6,5.9]

0.02

0.66

1

HOMA-IR

2.4 [1.9,2.9]

1.6 [1.1,2.1]**

1.9 [1.3,2.4]

2.0 [1.5,2.6]

3.6 [3.2,4]

2.0 [1.6,2.4]***

2.3 [1.9,2.7]***

2.9 [2.4,3.3]**

0.03

0.06

0.91

ISIClamp [mg kg−1 min−1/(mU l−1)]

0.08 [0.07,0.09]

0.10 [0.09,0.11]***

0.09 [0.08,0.10]*

-

0.05 [0.04,0.06]

0.08 [0.07,0.09]***

0.07 [0.07,0.08]***

-

0.31

0.23

-

Total cholesterol [mg/dl]

200.4 [190,210.9]

171.2 [160.8,181.6]***

192.5 [181.4,203.7]

192.4 [181.3,203.6]

198.1 [189.7,206.5]

167.5 [159.1,175.9]***

188.8 [180.1,197.5]*

191 [182.1,199.8]

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1

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LDL-Cholesterol [mg/dl]

121.2 [112.2,130.2]

102.1 [93.1,111.1]***

114.6 [105,124.1]

117.2 [107.6,126.7]

121.8 [114.5,129]

103.4 [96.1,110.6]***

113.7 [106.2,121.2]*

118.4 [110.8,126]

1

1

1

HDL-Cholesterol [mg/dl]

55.5 [51.9,59.2]

49 [45.3,52.6]***

58 [54.2,61.8]

58 [54.2,61.8]

44.4 [41.5,47.4]

41.8 [38.9,44.7]*

49.9 [46.9,52.9]***

49.3 [46.2,52.3]***

0.06

0.43

0.99

Triglycerides [mg/dl]

119.1 [97.0,141.2]

96.1 [74.1,118.2]

95.5 [70.9,120.0]

101.9 [77.3,126.5]

176.8 [158.9,194.8]

110.1 [92.2,128.1]***

149.1 [130.2,168.1]*

138.8 [119.4,158.3]***

0.01

1

1

Systolic RR [mmHg]

127.6 [122.4,132.8]

118.7 [113.6,123.9]*

121 [115.2,126.7]

121 [115.0,126.9]

132.4 [128.0,136.7]

121.4 [117.1,125.6]***

125 [120.5,129.5]

127.6 [122.9,132.3]

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Diastolic RR [mmHg]

80.6 [77.8,83.4]

74.1 [71.2,76.9]***

77.9 [74.8,80.9]

79.8 [76.6,82.9]

80.5 [78.1,82.8]

74.8 [72.5,77.2]***

79 [76.6,81.4]

78.1 [75.6,80.6]

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  1. Values shown (except for n, randomization, and age) are estimated marginal means with 95% confidence intervals from model with adjustment to sex, age, and randomization
  2. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. T-3 in respective group
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Nutrition & Metabolism

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